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Fever Pitch (7.15.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week on RheumNow.com

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Can Antimalarials be Withdrawn in Quiescent Lupus?

d Jack Cush, MD

Antimalaria (AM) therapy is a cornerstone to the management of systemic lupus erythematosus (SLE), yet a recent study suggests that slowly tapering AM yields a lower rate of SLE flares. 

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Still’s Disease FAQs

d Jack Cush, MD

What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and as importantly, which ones are not? What about complications? Read on for these and other FAQs regarding Still's disease.

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MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis

d Jack Cush, MD

A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of Myeloid-related protein 8/14 (MRP8/14) in diagnosing systemic JIA patients (SJIA) in clinical practice.

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Rituximab Induction and Maintenance in Older ANCA–Associated Vasculitis Patients

d Jack Cush, MD

A cohort study suggests that rituximab (RTX) use among patients 75 years and older with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is efficacious but also has a high risk of serious adverse events, likely related to associated steroid use and the advanced age of the po

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QD Clinic - Stills (or Not) with Hives What do you think? 40 yr. woman with fevers, hives, and LFTs. https://t.co/IZNnWzerOL https://t.co/sUGPuy2tKC

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mitochondrial DNA can drive SLE by PMN uptake, NETs, activation of STING & type-I IFN. Maybe same for Autoinflammatory responses were oxidized mtDNA provokes cGAS-STING, binding cytosolic NLRP3, triggering inflammasome activity. https://t.co/sTDTkoMQX2 https://t.co/wXhVzzIFRC

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Steroid Injection for Chronic Achilles Tendinopathy Adding a corticosteroid shot to exercise therapy significantly improved symptoms of chronic Achilles tendinopathy, a 100-person randomized trial found. https://t.co/sdYmsVpBsU https://t.co/r9zFVUmE88

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Watch: What's new in sarcoidosis? https://t.co/GnU1FDnUhn https://t.co/H1omKPtQmn

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NEJM Case - 17-Year-Old Girl with Fever and Cough and B/L lower lobe infiltrates. 3 wk hx started w/ conjunctivitis, SOB, Cough fever myalgia & knee pain. No rash. T 38.5°C, W 11.5, H/H 6.9/21, P526k, CRP 77mg/L, UA 2+ protein, neg COVID tests. https://t.co/VOiW7DIdBR https://t.co/1GWA2gAgeK

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1 yr success of knee arthroplasty was drawn frm 20 studies (11 317 pts, 37 factors) suggests higher BMI was correlated w/ worse physical function. Physical function & OA severity assoc. w/ better function post-TKA https://t.co/jtDCeprUhd https://t.co/Tflw8VO5Kw

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Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin lesions, muscle weakness, and ILD. https://t.co/EUOB8XUCht https://t.co/SYeYwooUkW

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Worldwide metanalysis of FUO shows most common infections to be Mycobacterium tuberculosis (34%), brucellosis (10%), endocarditis (7.5%), abscesses (7%), herpesvirus (CMV,EBV 7%), pneumonia (6%), URI (6%), enteric fever (5%) https://t.co/RPMb1kYEI9 https://t.co/E0lrizOUkF

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What's going on here? https://t.co/3jwbRazJhc
Andy Tran andy23tran ( View Tweet)
When to think beyond infection in recurrent fever??Join us to learn a clear approach to fever and auto inflammatory disorders from expert faculty @bhat_chandrika at #cusp @rakshay_shetty @PedRheum @PeriodicFeverUK @LatikaGupta_ @DrPujaMehta1 https://t.co/roMVbBDaNK
RCHPediatrics RchPediatrics ( View Tweet)
@DrPujaMehta1 @leticiakawano @docrota @DrJoPorter @drharsha_gunawa @best_rheum @jeffsparks @AshimaMakol @pedrommcmachado @KaminskiMed @KerriBerriKerri @DrPeter_George @scott_matson @LatikaGupta_ What about this one https://t.co/E6oMCFlplt
Hector Chinoy drhectorchinoy ( View Tweet)
Pleased to share our review Management of #Myositis #ILD practical guide for clinicians #Teamwork ✍️💪 @docrota 🇺🇸 🖐️ @DrJoPorter 🫁 @drharsha_gunawa 🖐️ OpenAccess😃 https://t.co/fhCHvzXdVP 3 clinico-serological phenotypes 1⃣ anti-synthetase 2⃣ anti-MDA5 3⃣ anti-PM-Scl /1 https://t.co/B1Qh0drSbg

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Puja Mehta 🧩 DrPujaMehta1 ( View Tweet)
#idboardreview #meded #idmeded #IDtwitter #dermtwitter #MedTwitter Infectious differential diagnosis of rash involving palms & soles https://t.co/xXK4nYwEoi
Indiana University Infectious Diseases Fellowship IUIDfellowship ( View Tweet)
🆕🌟CDC Guidance on COVID-19 Vaccines for Children <18 yrs who are Immunocompromised 👦👧🏾💉⬇️ Thank you Dr. Rebecca Sadun for reviewing! #PedsTwitter #PedsRheum #Pediatrics https://t.co/eeuRKflhSO
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)
French registry of IBD due to IL-17 inhib revealed 32 pts- risk of new IBD was low & decreased 2016 to 2019, w/ good outcome in 24/31. IBD more common w/ AS (27) vs PsO (4), IBD onse after 4 (1.5–7.5) mos; all cases w/ secukinumab https://t.co/FJAvhmzPkc https://t.co/WSIut9mAEq

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