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Gabapentin Implicated in Overdose Deaths

d Jack Cush, MD

Recent FDA and MMWR warnings suggest that gabapentin was present and implicated in almost 10% of US overdose deaths between 2019 and 2020. This CDC report also stated that gabapentin was the cause of the death in half of these cases. 

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heart,cv,meds, events, CVD

HCQ for RA: Not a Great Idea?

d MedPage Today

Hydroxychloroquine (HCQ) appeared less safe from a cardiovascular standpoint than methotrexate in older patients with rheumatoid arthritis (RA), analysis of Medicare data indicated.

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Are You Wasting Money on Supplements or Vitamins?

d Jack Cush, MD

The US Preventive Services Task Force (USPSTF) has updated its recommendations regarding the efficacy of supplements or multivitamins for reducing the risk of cardiovascular disease, cancer, and mortality in the general adult population.

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Inferior IL-17 Inhibitor Responses in Psoriatic Women

d Jack Cush, MD

Pooled data from two large ixekizumab (IXE) trials show that male patients had greater clinical responses than did female patients with psoriatic arthritis are largely unexplored. Reasons for this differential treatment responses to an interleukin-17A inhibitor (IXE) between male and female patients is unexplained.

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Patients in the COVID-19 Global Rheumatology Alliance were Surveyed; responses from 9300 Rheum Dz adults (RA 39%, SLE 31%) showed that 27% had a change in employment status during COVID (w/ 13.6% decrease in full-time employment) https://t.co/exi6KDmMGT https://t.co/fPl091rXdO

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Dr. John Cush RheumNow ( View Tweet)
JAMA Patient Page on "What is Carpal Tunnel Syndrome ? A great patient resource, full read with graphics https://t.co/5MT63IG0um https://t.co/fkY2LUb2UN

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Dr. John Cush RheumNow ( View Tweet)
New blog--I Need a Nemesis Your nemesis needn't be a the enemy or a demon, but should be the dragon(s) you slay and what drives you daily in becoming a better you. https://t.co/cJU7SLbUhp https://t.co/BsVfxT9sad

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Dr. John Cush RheumNow ( View Tweet)
Two Week MTX Hold with COVID-19 Vaccination A cohort study of RA patients evaluated immunogenicity of COVID vaccination with and without holding MTX for and 2-weeks and showed better immunogenicity, but more RA flares with the second MTX withdrawal. https://t.co/Kqa8Uy9tDm https://t.co/UvMHo8xAw8

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Dr. John Cush RheumNow ( View Tweet)
EMA has approved Secukinumab for the expanded approvals for use in pediatric patients with enthesitis-related arthritis (ERA) and psoriatic arthritis (PsA) . Approvals based on the JUNIPERA trial, showing reduced the risk of flare & Dz activity w/ SEC https://t.co/fN01V1PBfY https://t.co/UgULLHunky

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Dr. John Cush RheumNow ( View Tweet)
Exercise and fibromyalgia? Metanalysis of 18 studies & 1184 pts, comparing aerobic, resistance & stretching. All 3 had large & significant effect on pain (not diff from each other); also improves QOL (possibly depression) https://t.co/jVpLXN5oTw https://t.co/si1HjpP0wY

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Dr. John Cush RheumNow ( View Tweet)

Dr. Baraf is a giant in the rheumatology community ! A nnovative researcher, grand teacher, & masterful clinician make him memorable; but most of all - he's a great friend and kind man! Standing-O for Herb! https://t.co/UREDeSyGRJ

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Dr. John Cush RheumNow ( View Tweet)

Of the Top 20 most expensive drugs in USA in 2022, only two are for rheumatic reasons. Unfortunately both are for ACTH preparations, once cheap, now devastatingly expensive: #11 Acthar Gel ($41,459/month) & #19 Cortrophin Gel ($30,083) https://t.co/avUZNVnHRp https://t.co/mXLhD8vJ6A

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Dr. John Cush RheumNow ( View Tweet)
Study of new onset #RA & undiff arthritis pts starting Rx 2005-2010; mean F/U 104 mos, 11% died. Steroids (<7.5/d) given to 44% initially, ultimately 57% w/ 20% recv >7.5/d. Steroids did not increase mortality (HR 1.35 ; 0.74, 2.47) or hospitalization https://t.co/KNpobs1UwH https://t.co/sjddMBKOeE

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Dr. John Cush RheumNow ( View Tweet)
A reflex slide I put together for you. https://t.co/HMumN7WaJY
Oren Gottfried, MD OGdukeneurosurg ( View Tweet)
Renal Tubular Disorders #NephTwitter #MedEd #MedDoodles https://t.co/KiCuEaDGrR
Sarah Lyon sarahthelyon ( View Tweet)
It's time to exonerate methotrexate in causing or exacerbating fibrotic interstitial lung disease in #RA patients https://t.co/AuEIWn8Pc4 https://t.co/razVTF6fFX

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Dr. John Cush RheumNow ( View Tweet)
Simultaneous Versus Staged Knee Arthoplasty? There are an estimated 900,000 knee replacements (TKR) performed in the U.S. every year. This number is up from 754,000 TKRs in 2017, according to the Agency for Healthcare Research and Quality. https://t.co/KuLEaI3r0d https://t.co/0q1RBsDwEM

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Dr. John Cush RheumNow ( View Tweet)
FDA approved Abbvies risakizumab-rzaa (Skyrizi) as the 1st interleukin-23 inhibitor for use in adults with moderately to severely active Crohn's disease (600 mg IV at wk 0, 4, 8, &q8wk @ 360 mg SC). Approval based on ADVANCE, MOTIVATE & FORTIFY RCTs https://t.co/OMYNB1yr2R https://t.co/QMn9GWlYm9

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Dr. John Cush RheumNow ( View Tweet)

JAK/STAT pathway in pyoderma gangrenosum: a new therapeutic highway? Pyoderma gangrenosum (PG) is rare, but often associated with different forms of arthritis, in particular rheumatoid arthritis and inflammatory bowel diseases. https://t.co/SvkcZwqzBo https://t.co/M3BkoF4amb

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 7 studies shows that oral anticoagulants need not be discontinued for joint injections or aspiration. Only pts w/ hemorrhage after 5427 procedures, over 32-yrs. INR values of 3 bleeding cases was 1.9, 2.3, and 3.4. https://t.co/pCxDqzXGHQ https://t.co/ExZkXSliFo

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Dr. John Cush RheumNow ( View Tweet)

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