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Spinal Findings on MRI May Not Signify Spondyloarthritis

d Jack Cush, MD

For about one in six people considered healthy with no reports of back pain, lesions were visible on MRI in the lower spinal column and sacroiliac joint, researchers said -- a sign that rheumatologists should be cautious about diagnosing spondyloarthritis (SpA) on the basis of imaging.

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Abatacept Most Effective Early and in Seropositive RA

d Jack Cush, MD

An open-label, 2 year study evaluated the efficacy and safey (drug retention) of subcutaneous (SC) abatacept (ABA) in active rheumatoid arthritis (RA) and showed superior responses when ABA was given to biologic-naive and seropositive RA patients. 

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Leflunomide versus azathioprine in lupus nephritis? Study of 215 bx proven LN given either LEF or AZA - Renal flares were equal (15.7% v 17.8%), as was time to flare (16 mo vs AZA 14 mo); 24-hr proteinuria, creatinine, C3 and C4 improved similarly. https://t.co/FEKwwyoJhZ https://t.co/zUyHXGjpOD

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Rheumatologist Survey: What do you rely on MOST in diagnosing Still’s disease? Sxs? Labs? Both? Criteria? Fever? Vote here: https://t.co/L1kyWXf68I

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Watch: Remote Monitoring Technologies in the Management of RA Dr. Antoni Chan interviews Dr. Johannes Knitza at EULAR 2022 https://t.co/SU9SUScHiS https://t.co/YoxQPZH5eQ

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Seminal Articles on Stills disease Tues Nite Rheum Journal Club tommorrow Discussants: Drs. Bella Mehta, Michael Weisman & Jack Cush 7pm EDT (4pmPDT) - The 1st articles on AOSD from Bywaters & Bujak https://t.co/yRgHlmZHhi https://t.co/ooexkgM6ga Register: https://t.co/kstge3gAcl https://t.co/XjQJi4FRmt

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Study of 50 #AOSD pts refractory to steroids (n=11), DMARDs (34) & biologics (n 30): given canakinumab 150–300 mg q 4wk (47) or q8wk(3). W/ 27 mos F/U: 78% complete resp w/in 3 mos (20% partial). Steroid sparing in 1/2, Low WBC 6%, 4%SIE https://t.co/QMCLictdrL https://t.co/5hkUOBFDG0

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Myths & Misconceptions with Febrile Disorders Dr. Rachel Tate ( @uptotate) weighs on the myths and misconceptions with Still's disease and autoinflammatory disorders. https://t.co/z0KHbxnLjJ https://t.co/ymsXYDP5Zs

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QD Clinic - Stills (or Not); A Wife's Letter A letter from the wife of a hospitalized febrile patient says it all. But, is this Still's disease or not? https://t.co/MpPbDU9ZTB https://t.co/BqpusOKKLq

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213 #SLE pts were screened for Cryoglobulinemia (2013 -2017); CG is frequent in SLE (66%), but mostly asymptomatic. Mean levels 40mg/L (0-228). Cryo Vasculitis in 15% w/ purpura, ulcers, digit ischemia, arthritis, GN (5%) or CNS (19%) https://t.co/R6xUJldgC2 https://t.co/mwsSTI3ztk

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Can Antimalarials be Withdrawn in Quiescent Lupus? Antimalaria (AM) therapy is a cornerstone to the management of systemic lupus erythematosus (SLE), yet a recent study suggests that slowly tapering AM yields a lower rate of SLE flares. https://t.co/dYJy5BOKay https://t.co/pgz694ep2G

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Still’s Disease FAQs What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and which ones are not? What about complications? Read on... https://t.co/rsFHNPwo9Y https://t.co/AUP1GpbDaN

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Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/uMY5uPPabA https://t.co/nG2RO6oEJQ

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Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin lesions, muscle weakness, and ILD. https://t.co/cYZ1YEGBOr https://t.co/MDNTSje6a2

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10% of PsA is PsA Sine Psoriasis - how to differentiate from seroneg RA? PsA sine PsO pts have peripheral arthritis, no skin dz, but may have axial sxs, +Family Hx or nail psoriasis, dactylitis, enthesitis, DIP involvement. https://t.co/2RjGU6Fw2j https://t.co/r7Dsqtksh5

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Watch: Comanagement of Psoriasis and Psoriatic Arthritis https://t.co/oo2Vhiwubq https://t.co/iikYssIepQ

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New download available! We're providing an introduction to Still's Disease. https://t.co/67XzncaUef https://t.co/gaMNGk0grn

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MTX + Pegloticase Combo FDA Approved Horizon has announced that the FDA has approved the expanded labeling of pegloticase (Krystexxa) injection to be co-administered with methotrexate (MTX), to improve response rates in patients with uncontrolled gout. https://t.co/D71dmMuB9B https://t.co/jonfLqQ0lj

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Proposed investigations (findings) in the diagnosis of Stills disease: - CRP, ESR, Ferritin (high) - W/U for infection, cancer (negative) - Serologies (negative) - consider Imaging (CXR, CT, US, PET) https://t.co/ByNSq8YACC https://t.co/BdhfRjPA6L

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New podcast ready for download! Fever Pitch--Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week. https://t.co/GdntsVNyfS https://t.co/3QdJHNlIKQ

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