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Infectious Mortality in Autoimmune Rheumatic Disorders

Jack Cush, MD

Infectious conditions are a significant cause of mortality in autoimmune rheumatic diseases (ARD). Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD.

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Small-molecule Drugs to Treat Systemic Lupus Erythematosus

Jack Cush, MD

A metanalysis of randomized controlled trials (RCTs) on treatments of systemic lupus erythematosus (SLE), confirm the efficacy of several targeted small-molecule drugs. 

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Interferons and Lupus Subsets

EurekAlert!

In a new study, researchers from Johns Hopkins Medicine say they have uncovered insights as to the relationship between interferons and lupus, which affects up to 1.5 million Americans. 

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Multiplicative Adverse Effects of Social Determinants of Health in Lupus Nephritis: A Meta-analysis and Systematic Review

Jack Cush, MD

A metanalysis shows that social determinants of health adversely impacts patients with lupus nephritis. Lupus nephritis is a significant complication of SLE, often with dramatic increases in morbid and mortal risks. Outcomes are likely to be augmented by social determinants of health, including socio-economic status, and social risk factors.

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Featured BSR Abstracts (5.2.2024)

Jack Cush, MD

Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.

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Small-molecule Drugs to Treat Systemic Lupus Erythematosus A metanalysis of randomized controlled trials (RCTs) on treatments of systemic lupus erythematosus (SLE), confirm the efficacy of several targeted small-molecule drugs. https://t.co/O3Y3KBngau https://t.co/wiB1EMtMFK

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Dr. John Cush RheumNow ( View Tweet)
Interferons and Lupus Subsets In a new study, researchers from Johns Hopkins Medicine say they have uncovered insights as to the relationship between interferons and lupus, which affects up to 1.5 million Americans. https://t.co/Eo8q3IGPb7 https://t.co/gVyHJwZFwc

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Dr. John Cush RheumNow ( View Tweet)
Save the date! We’ll be covering #EULAR24! https://t.co/HGjP2SFyOp
Dr. John Cush RheumNow ( View Tweet)
10 Lupus Tips on May 10 (World Lupus Day) by @LupusMore https://t.co/mON5ZyTpUE #lupus #SLE #LupusAwarenessMonth

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Donald Thomas, MD lupuscyclopedia ( View Tweet)

✅ Holistic #Lupus Management in 2024 👍 #LupusAwarenessMonth https://t.co/RY6AcHS9WQ

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Laurent ARNAUD Lupusreference ( View Tweet)
Multiplicative Adverse Effects of Social Determinants of Health in Lupus Nephritis: A Meta-analysis and Systematic Review https://t.co/C6G3VePklU https://t.co/zVoLeI8ZxA

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Tuesday Night Rheumatology- Mastering SLE This webinar will feature highlights from these lectures followed by live audience Q & A https://t.co/CLJbtvJKOT https://t.co/hGSK4P7NlF

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Dr. John Cush RheumNow ( View Tweet)
CD19 is not expressed on Plasma Cells or Plasmacytoid dendritic cells. Yet, Selective CAR-T cell mediated B cell depletion suppresses interferon signature in SLE !! https://t.co/3DsonHZiWp https://t.co/dk5ZtQRnOm

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Dr. John Cush RheumNow ( View Tweet)
SLE Faculty Panel Q&A https://t.co/2OWlhfmKaP https://t.co/jx6MPDtojS

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Dr. John Cush RheumNow ( View Tweet)
FDA issued a drug safety warning linking thiopurine (AZA, 6MP) use in pregnancy & a rare risk of intrahepatic cholestasis of pregnancy (ICP). ICP has been reported in pts w/ CD, UC, or SLE; however thiopurines are not FDA approved for these Dx https://t.co/s37eRuAtQx

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Dr. John Cush RheumNow ( View Tweet)

Very late onset Lupus (>60) is less female, less arthritis/dz activity, lower dsDNA, C3, SSA, SSB and ANA but more Sjogrens & RA? Single clinic study of 845 SLE - jSLE (<18), aSLE (18-49), lSLE (50-60), and vlSLE (>60).vlSLE had lowest survival (20yrs) https://t.co/VwDSArDhrc https://t.co/3pSr0xSCKn

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Dr. John Cush RheumNow ( View Tweet)
“50% of pts with lupus nephritis are asymptomatic . You have to have a degree of kidney damage before you have proteinuria. Proteinuria does not correlate with intrarenal activity.” – Dr. A Fava #RNL2024 @rheumnow https://t.co/w6UktVozsj

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Dr. John Cush RheumNow ( View Tweet)

Full-read Overview of Macrophage Activation Syndrome - a rare complication of autoimmune inflammatory rheumatic dz; assoc w/ Still’s disease SLE, Kawasaki, dermatomyositis, RA, Sjögren’s. Precipitating factors, including genetics & infections reviewed https://t.co/LmL3BPmo6c https://t.co/OkfwpzNLAL

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Dr. John Cush RheumNow ( View Tweet)
"Clinical Pearl! Lupus flare mimics with Dr. Kahlenberg - FM - Stress - Infection - Lack of sleep - Iron deficiency - Vitamin D deficiency - Celiac or other concomitant inflammatory disease - thyroid issues @Kahlenberglab #RNL2024 https://t.co/byNpSPuzC0"

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Dr. John Cush RheumNow ( View Tweet)

Biology and Rx of Lupus Flares https://t.co/VlaI1PK8X8 https://t.co/oFXqGUvL4b

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Dr. John Cush RheumNow ( View Tweet)
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