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Long COVID Manifestations

d MMWR

The acute consequences of a SARS-CoV-2 infection may be bothersome or devastating, but the long-term consequences may lead to so-called "long COVID" syndrome.  Long COVID appears to affect up to 20% of those who survive COVID-19 infection. 

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To TDM or Not in Rheumatology?

d Jack Cush, MD

Therapeutic Drug Monitoring (TDM), especially for biologic therapies, has become a standard in gastroenterology, but shunned by most rheumatologists.

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Can SGLT2 Inhibitors Be Protective in Lupus and Vasculitis?

d Jack Cush, MD

SGLT2 inhibitors are all the buzz in the renal world with reports of a renal protective and mortality lowering effects. Maybe these agents should be considered and studied in lupus nephritis and ANCA- associated vasculitis.

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Amitriptyline and FDA Treatments for Fibromyalgia

d Jack Cush, MD

Both old and newer pharmacological treatments for fibromyalgia are often promoted; but a recent systematic review and network meta-analysis showed that duloxetine had higher efficacy in pain and depression, while amitriptyline had higher efficacy in treating sleep, fatigue, and quality of life outcomes.

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86 #SLE pts w/ pulmonary embolism (age 38 yrs; avg lupus duration 46.5 mos) found 20% died; 1 yr (83.4%) & 3-year survival (79.4%). Mortality Predictors = Thrombocytopenia & lymphocytopenia. HCQ & anticoagulation were protective https://t.co/ot7H6LeLmu https://t.co/WdPgvOF8jJ

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Dr. John Cush RheumNow ( View Tweet)
Amitriptyline and FDA Treatments for Fibromyalgia #MedEd https://t.co/9PylojjL4S https://t.co/TxErjtU4eE

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Dr. John Cush RheumNow ( View Tweet)
It's our 8th year covering this important meeting! Join us June 1 - 4 for key opinion leader perspectives, clinical trial highlights and more, as we cover #EULAR2022. https://t.co/eHziBN3TWk
Dr. John Cush RheumNow ( View Tweet)
Congratulations to Dr. Alexis Ogdie for being appointed Director of the Center for Clinical Epidemiology & Biostatistics at the Perelman School of Medicine at U Penn. CCEB is an interdisciplinary prg focused on research and educational thhttps://bit.ly/39N96Ok https://t.co/RlRCuYO7VV
Dr. John Cush RheumNow ( View Tweet)
May 2022 EMA meeting the CHMP recommended new indications for Cosentyx (juvenile PsA, Enthesitis-related arthritis), Olumiant (alopecia areata), Rinvoq (ulcerative colitis) and Xeljanz (ankylosing spondylitis). EMA approval pending https://t.co/KauDY6e8zS https://t.co/mmv4G9jHI7

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Dr. John Cush RheumNow ( View Tweet)
NSAID use is not associated with increased COVID-19 severity, all-cause mortality, invasive ventilation, AKI, or ECMO in COVID-19 inpatients. 38-center retrospective cohort propensity matched of EHR data from the National COVID Cohort Collaborative. https://t.co/u6Id4WnLPT

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Dr. John Cush RheumNow ( View Tweet)

Disease modification has been defined in multiple disease areas but no widely accepted definition exists for SLE. Learn about the benefits & why there’s a need to consider therapies that modify the immunologic mechanisms of SLE. Sponsored by GSK USMA https://t.co/012Wk0d9Uu https://t.co/yteiuKDLLL

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Dr. John Cush RheumNow ( View Tweet)
Study of 282 inflammatory arthritis (IA) pts Rx with TNFi, 11 (3/9%) had neutralizing anti-drug Abs (nADAb). nADAb+ was more likely in smokders; such had significantly worse Dz activity, physical function, & inflammatory markers https://t.co/TnEKGpTQ85 https://t.co/I0hv5X35P1

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Dr. John Cush RheumNow ( View Tweet)
""It's easy to make a buck. It's a lot tougher to make a difference." - Tom Brokaw

Dr. John Cush RheumNow ( View Tweet)

NEJM Case: 73 yoM w/ 1 mo hx of fatigue & diffuse bone pain, pancytopenia (no abd pain, neuro Sx of HSM). WBC 1.7, Hgb 5.9, P111k, MRI shows AVN femura & Humerus. Bone marrow bx revealed macrophages w/ “wrinkled tissue paper” https://t.co/raObXpTHBr https://t.co/U6nQnPKtqI

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Dr. John Cush RheumNow ( View Tweet)
Medscapes list of Best & Worst States to Practice Best 5: 1) Idaho 2) Georgia 3) S. Dakota 4) Texas 5) Indiana Worst 5: 1)Maine 2)Maryland 3)W.Virginia 4)Rhode Island 5)Wash DC https://t.co/4faJiy9l3D https://t.co/k9WKqo8pah

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Dr. John Cush RheumNow ( View Tweet)
VA and Marketscan data analysis ~345k RA pts shows multimorbidity increased in RA; over-represented are cardiopulmonary, cardiometabolic, and mental health and chronic pain disorders (OR 1.17 - 2.96). https://t.co/awcGQPAdiN https://t.co/c4mLkDzvCM

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Dr. John Cush RheumNow ( View Tweet)
Inflammatory Arthritis Spread by ATP and Neural Crosstalk A novel study suggests that a reflex neural signaling at sites of inflammation may lead to spread to other inflammatory sites via and ATP-mediated neural crosstalk. https://t.co/vaFjqCPKtp https://t.co/RQV6qFh1pw

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Dr. John Cush RheumNow ( View Tweet)
Biologic Persistence in Psoriatic Arthritis and Psoriasis Recent studies examined the durability and persistence of biologic agents in patients with PSO and PsA and while some differences were noted overall persistence was low 3 years later. https://t.co/sqxVaLnXEY https://t.co/yUPWYkRxva

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Dr. John Cush RheumNow ( View Tweet)
Watch: Lupus Nephritis: The Blind Men and the Kidney with Dr. Joan Merrill Joan Merrill discusses treatment of lupus nephritis. This was previously recorded at RheumNow Live 2022. https://t.co/IDjOT3Acs0 https://t.co/HkYcoRx5P4

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Dr. John Cush RheumNow ( View Tweet)
Countdown to Step 2, each week I'll be posting one of my favorite doodles from studying! This week- Pulmonary Arterial Hypertension #Meddoodles https://t.co/Hj1i87zZbA
Sarah Lyon sarahthelyon ( View Tweet)

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