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Immune Checkpoint Inhibitor Associated Arthritis
Immune checkpoint inhibitors (ICIs) have dramatically improved outcomes in numerous cancers but have been hampered by a growing spectrum of immune-related adverse events (irAEs). Rheumatic complaints may be less frequent than other irAEs associated with ICI in cancer patients.
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Bridge Prednisone Use Fails to Improve Outcomes
A one year, X-ray outcome trial has shown that the initial use of prednisone (high or low dose) in newly treated active early rheumatoid arthritis (RA) did not improve radiographic outcomes.
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RNL 2022: Rheumatoid Arthritis - Best Management
This week's Tuesday Night Rheumatology, hosted by Dr. Jack Cush, featured highlights from the 2022 RheumNow Live Rheumatoid Arthritis - Best Management Pod, followed by a lively audience Q & A. Lectures featured:
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Cardiovascular Risk in Calcium Pyrophosphate Deposition Disease
A recent EHR study shows that acute CPPD crystal arthritis was significantly associated with elevated risks for non-fatal CV events.
https://t.co/c0Nbjko3OQ https://t.co/SC9J80ROFT
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Dr. John Cush RheumNow ( View Tweet)
Watch: Who Killed Caravaggio?
Peter Nash, MBBS, FRACP shares thoughts on what or who exactly killed Caravaggio six centuries ago.
https://t.co/9iOlArIIpb https://t.co/GQX8aDZGjy
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Dr. John Cush RheumNow ( View Tweet)
Increasing Corticosteroid Use in Non-Hospitalized COVID-19
JAMA reports that despite NIH recommendations, non-hospitalized COVID infected patients were oftent prescribed systemic corticosteroids.
https://t.co/1BADbI5j3z https://t.co/QtZZd7UJkc
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Retrospective pregnancy outcome study in 154 Rheumatic pts. Systemic sclerosis pts had higher risk of adverse preg outcomes (vs HC - 60.6% vs 10.0%; OR = 14; SSc had increase in 1st trimester miscarriage, preeclampsia, SGA & Preterm https://t.co/hfd6SsCRmr
Conclusions
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Single center muscle bx of 860 pts muscle biopsy had 531 with IIM (61.7%), 253 with non-IIM (29.4%), and 76 undiagnosed (8.8%). 7.9% were classified as immune mediated necrotizing myositis, 40% DM, 9.5% synthetase synd, IBM 0.3% https://t.co/KTsjpu0qPY
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Dr. John Cush RheumNow ( View Tweet)
Long COVID Manifestations
The acute consequences of a SARS-CoV-2 infection may be bothersome or devastating, but the long-term consequences may lead to so-called "long COVID" syndrome. Long COVID appears to affect up to 20% of those who survive COVID-19.
https://t.co/Oh5R9xPKYD https://t.co/5iRVEjdWZW
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Dr. John Cush RheumNow ( View Tweet)
Disease modification has been defined in multiple disease areas but no widely accepted definition exists for SLE. Learn about the benefits & why there’s a need to consider therapies that modify the immunologic mechanisms of SLE. Sponsored by GSK USMA https://t.co/GV20emEpki https://t.co/onX7To2zvn
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Can SGLT2 Inhibitors Be Protective in Lupus and Vasculitis?
SGLT2 inhibitors are all the buzz in the renal world with reports of a renal protective and mortality lowering effects
https://t.co/b7YupKPJr7
#MedEd https://t.co/AYPeX360Gv
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Amitriptyline and FDA Treatments for Fibromyalgia #MedEd
https://t.co/zA4rycnHg4 https://t.co/TxD1jp6XGf
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Dr. John Cush RheumNow ( View Tweet)
Watch: Lupus Nephritis: The Blind Men and the Kidney with Dr. Joan Merrill
Joan Merrill discusses treatment of lupus nephritis. This was previously recorded at RheumNow Live 2022.
https://t.co/9GRw5VGTKr https://t.co/PS6aEk1fsx
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Dr. John Cush RheumNow ( View Tweet)
Visit @RheumNow podcast channel & hear experts from the #SLEEducatorsNetwork review a new framework for defining disease modification in SLE and why there’s a need to consider therapies that modify the immunologic mechanisms of SLE. Sponsored by GSK USMA
https://t.co/gsrYmu5ufO https://t.co/Fmt21u3wUN
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Dr. John Cush RheumNow ( View Tweet)
Dr. Jack Cush reviews the news, regulatory updates and journal reports from the past week on https://t.co/V10S4oVFsv. This week gout worries, mortality risks, measuring anti-drug antibodies and a better way in lupus?
https://t.co/iaMQZtzdLm https://t.co/Zu9VwKoCAc
Dr. John Cush RheumNow ( View Tweet)
Looking forward to reading/watching the coverage of #EULAR2022 by our outstanding faculty, including Drs., Rachel Tate @uptoTate, Kathryn Dao @KDAO2011,
Robert Chao @doctorRBC , Janet Pope @Janetbirdope and Antoni Chan @synovialjoints . https://t.co/oBQCxzdzfF
Dr. John Cush RheumNow ( View Tweet)
Join experts from the #SLEEducatorsNetwork to learn more about our current understanding of SLE pathophysiology & why, given its progressive nature, there’s a need to try to change the course of this complex disease. Sponsored by GSK USMA @jeevsmd https://t.co/WkL1lU2JRJ https://t.co/g8iv6WUG5k
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Watch: Novel Treatment of SLE
Dr. Sonali Narain discusses new insights on existing treatments and newly approved therapy and soon to be approved therapies for SLE. #MedEd
https://t.co/7Op3R8IzV1
#MedEdTwitter https://t.co/qBMTbOBmyM
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Dr. John Cush RheumNow ( View Tweet)
Long COVID Manifestations
The acute consequences of a SARS-CoV-2 infection may be bothersome or devastating, but the long-term consequences may lead to so-called "long COVID" syndrome. Long COVID appears to affect up to 20% of those who survive COVID-19.
https://t.co/BFgazzEQWl https://t.co/0HyWZ3HcLG
Links:
Dr. John Cush RheumNow ( View Tweet)
Novel patient self-drawn capillary (CAP) tube blood testing for CRP/RF/CCP - YES, Pt does this at home! 49/50 seropos.RA pts successfully collected samples; , correlations w/ venous blood=excellent: CRP (0.992), CCP (0.984), RF (0.994) https://t.co/zLiwEpiyi9
Conclusions
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Dr. John Cush RheumNow ( View Tweet)