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$30 Billion and Counting (4.29.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports and takes viewer questions this week.

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SI,sacroiliitis,erosion

Prolonged TNF Inhibitor Use Delays Sacroiliac Progression

d Jack Cush, MD

While tumour necrosis factor inhibitors (TNFi) have been shown to alter/retard X-ray outcomes in peripheral inflammatory arthritis, the inhibitor effects of TNFi on axial skeletal progression in spondylitis has been difficult to prove, owing to difficulties in study design, identifying best cohorts and a presumed slower rate of change in the spine. 

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US,hip,injx

Intraarticular Steroids in Hip Osteoarthritis - Do They Work?

d Jack Cush, MD

The efficacy of ultrasound guided intra-articular hip injection of corticosteroid in adult hip osteoarthritis (HOA) was shown to be effective when added to conventional current treatment. But was this a clinically meaningful outcome?

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TNRPSA,0426

PsA Journal Club - Fecal Transplant & H2H IXE vs ADA

d Jack Cush, MD

Playback now available! Watch our Tuesday Nite Rheumatology, held April 26th, 2022, which featured a Journal Club panel discussion  about two important studies.

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Study of 33 #RA pts finds nearly half had peripheral neuropathy (48.5%); sensorimotor in 64.7%, motor in 17.6%. Neuropathy was NOT associated with age, gender, disease activity, functionality, or falls https://t.co/r2aQI2cm27 https://t.co/OOQlWkCAft

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Prolonged TNF Inhibitor Use Delays Sacroiliac Progression https://t.co/dz4d8q8XSy https://t.co/NWCAb0OH7B

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Intraarticular Steroids in Hip Osteoarthritis - Do They Work? https://t.co/AP9jo96xQo https://t.co/tYvP20Qpqh

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Playback now available! Watch our Tuesday Nite Rheumatology, held April 26th, 2022, which featured a Journal Club panel discussion about two important studies. https://t.co/RjFRFt6oJQ https://t.co/zOxCDC1atS

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Biologics for JIA? Not So Fast, Say Insurers It's not a simple matter to prescribe tumor necrosis factor (TNF) inhibitors for patients with juvenile idiopathic arthritis (JIA), at least those with insurance, a single-center study found. https://t.co/w4A5sgv3fU https://t.co/coVh3zui2z

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Arthritis Predicts Hepatic Fibrosis in Hemochromatosis https://t.co/AHnRkvq2wo https://t.co/zbl3HQRZCX

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Today the FDA expanded the indications for upadacitinib (Rinvoq) to include ankylosing spondylitis - specifically for adults w/ active ankylosing spondylitis after failing a TNF blockers or other DMARDs. https://t.co/A9QhT98Djj

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Study of PCP Dx irritable bowel dz; 459 randomised to 8 weeks of oral antispasmodics or diet (low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP). Better responses with diet (71% vs 61%; p=0.03). Better adherence w/ diet. https://t.co/gmn45yQmuB https://t.co/8SP5Vfx71z

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Nature study shows videoconferencing inhibits creativity (idea generation) because it focuses communicators on a screen, which prompts a narrower cognitive focus. Yet, virtual interaction might increase decision quality. https://t.co/0yTEcmtKye https://t.co/ruwOj9qJ9J

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Pregnancy outcomes in systemic sclerosis (SSc) studied in 154 pregnancies from SSc, SLE, APS, & controls (2008 to 2019). Adverse Preg Outcomes APO significantly higher in SSc vs HC (61% vs 10%) w/ more miscarriages, preeclampsia, SGA & preterm births https://t.co/P3uksmJy6V https://t.co/nTtgwjdGgL

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Miss this week’s Tuesday Night Rheumatology? We’ve got you covered. https://t.co/TuBeZTWG9d https://t.co/qWWBSXKKSW

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Perplexing Oligoarthritis, +FHx, But no psoriasis QD Clinic is sponsored by RheumNow's PsA All the Way Campaign in April 2022 https://t.co/ljZ1cStNTy https://t.co/8RMFFWjDEP

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SLE (n=2428) pts followed for 224,295 Pt-months- Osteonecrosis seen in 122 pts (6.5/1,000 PtYrs). Higher ON risk - African Americans (2x), Male (1.8x), smokers (1.5x). Higher Rates w/ high dose prednisone (not pulse or IM TCA) https://t.co/omU9Z1Z3kU https://t.co/wceGoCcUBV

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Systematic literature review of studies where steroids were used as initial "Bridge Therapy" in RA patients - included 10 studies, but only 4 RCTs w/ protocolized discontinuation - these showed 22% were still on GC @ 12 mos, 10% @24 mos https://t.co/aRLhptAASe https://t.co/lg4msIyQfc

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Watch: Dr. Ritchlin discusses Future Discovery and Targets. https://t.co/MOQjXWd6tc https://t.co/EQWBnL9jzI

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Spanish BIOBADASER registry real world performance of secukinumab in 639 pts w/ #PsA & spondyloarthritis (axSpA, AS, NR axSpA) showed imprved Dz activity at 1 yr & maintained or increased 2 & 3 years. Retention rates best when SEC used 1st biologic https://t.co/MAE3BhLlRg

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