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Diagnostic Delays in Spondyloarthritis Still Prolonged
Previously quoted average delay in diagnosing axial spondyloarthritis (axSpA) may be improving as a recent UK study shows the mean average time to diagnosis in two different NHS trusts was between five and six years.
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Expansive (full read) review of CBD - legal and regulatory overview, availability, physiologic and pharmacologic effects, safety, & risks, standards, use in specific rheumatic disorders. https://t.co/hefwKTmPLK https://t.co/IZKZMOZ5ij
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TOMORROW! Register for our 5/10 Tuesday Night Rheumatology on PsA Advances.
This webinar will feature highlights from:
PsA Guidelines
Arthur Kavanaugh, MD
Drug Targeting in PsA
Bruce Kirkham, MD
PsA Registries and Real World Data
Alexis Ogdie, MD
https://t.co/0fNuHz6wVy https://t.co/KssNJ41Wqz
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DOCTORS: are you ready to attend big medical meetings ? @LCalabreseDO
Dr. John Cush RheumNow ( View Tweet)
Allopurinol Use Does Not Increase Mortality in Gout w/ Chronic Kidney Disease
A trial has shown that allopurinol use dose escalation and achieving target uric acid levels, was not associated w/ increased mortality in patients with gout and concurrent CKD.
https://t.co/8LHlRyTgS0 https://t.co/4Hu9cTwptO
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Hyperuricemia as a biomarker of severe #PsA? Study of 242 PsA pts 30% had hyperuricemia & 6% had gout. Hyperuricemia was significantly associated with age, comorbidity, perph polyarthritis, Jt destruction, less response to treatment. https://t.co/U5wAQdWLdC https://t.co/QfoaogDeun
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TLR7 signaling impt to SLE as it drives type I IFN & activation of autoreactive B cells. Nature reports missense TLR7 (Y264H) variant from severe lupus induces guanosine & cGMP & causes murine lupus when introduced into mice. https://t.co/VZioZfcJQ6 https://t.co/AtxWD4XGBF
Dr. John Cush RheumNow ( View Tweet)
Good free patient info handout on LUMBAR SPINAL STENOSIS from JAMA https://t.co/aDPwLzFvfQ
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Phase 2b DBRPCT of Intranodular injections of adalimumab in 140 pts w/ Dupuytrens contracture showed signif reduction nodule size and hardness ((−4·6 vs −2·2; p=0·0002) at 12 months https://t.co/9wBOeQNUdL https://t.co/HOR8rzYuRa
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Dr. Judith James on environmental factors that contribute to lupus risk and expression. #UTSWSLE2022 https://t.co/MGE51vlDMY
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GALAXI-1 Study - Guselkumab effective in Crohn's Disease. 309 CD pts (1/2 refractory dz) Rx w/ either PBO, or IV GUS 200 mg, 600 mg, or 1200 mg at weeks 0, 4, and 8; At week 12, all 3 doses had signif. clinical and endoscopic improvements vs PBO https://t.co/iGyAmCoO96
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RBCs from SLE patients retain mitochondrial proteins that may either lead to type I IFN or be taken up by myeloid cells. (V. Pascual) #UTSWSLE2022 https://t.co/VdQGRDUMvX
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Dr. Pascual shows that signatures show IFN or plasmablast or PMN/Myeloid signatures, thus identifying 7 subsets of lupus kids #UTSWSLE2022 https://t.co/3BAxPdAKw8
Dr. John Cush RheumNow ( View Tweet)
DOCTORS: are you ready to attend big medical meetings ? @LCalabreseDO
Dr. John Cush RheumNow ( View Tweet)
Clinical evidence of type I IFNa excess expressed in clinical SLE (Dr. Virginia Pascual) #UTSWSLE2022 https://t.co/To2U9ZtxU3
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Professor Chandra Mohan on pathogenesis and immunogenetics of #SLE - over 180 genes linked to the pathogenesis, modified by infection (bigger role for EBV?) hormones, smoking, hormonal status. #UTSWSLE2022 https://t.co/aKNpxZfdc6
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Efficacy of Subsequent b/tsDMARD Use in Rheumatoid Arthritis
https://t.co/5dXe0AdNzE https://t.co/eS4KdaKBmC
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Three (3) Worst Drugs to use in #Lupus patients who want to be pregnant (MTX, MMF, CTX) #UTSWSLE2022 https://t.co/YBeLTuRLO1
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Algorithmic approach to SLE and assessing/treating early pregnancy. #UTSWSLE2022 https://t.co/692el4R9sZ
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Adverse pregnancy outcomes and Risks in #SLE. (Dr. Eliza Chakravarty - OMRF) #UTSWSLE2022 https://t.co/HqscJD2m96
Dr. John Cush RheumNow ( View Tweet)