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COLCORONA: Protective Effect of Colchicine in COVID-19

Jack Cush, MD

Lancet Respiratory Medicine has reported the results of the COLCORONA trial, showing that in patients with PCR-confirmed COVID-19 infection, colchicine led to a significantly lower rate of death or hospital admission from COVID.

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RheumNow Podcast – Heart, Lung & Liver (5.28.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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Efficacy of 6 Weeks Antibiotics with Prosthetic Joint Infections

Jack Cush, MD

The NEJM has published the results of a French multicenter study showing that prosthetic joint infections can be successfully managed with 6 weeks of antibiotic therapy; this was noninferior and had better outcomes compared to 12 weeks of antibiotic therapy.

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CV Risk Decreased with Certain DMARDs in Rheumatoid Arthritis

Jack Cush, MD

A large prospective cohort study examined the comparative risks of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) and found that, methotrexate (MTX), abatacept (ABA) and TNF inhibitor (TNFi) use were associated with a decreased risk of CV events. 

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Tocilizumab Augmented Efficacy in COVID-19 Pneumonia with High CRP

Jack Cush, MD

JAMA Internal Medicine report an analysis of recent and composite trial data suggesting that tocilizumab (TCZ) therapy in COVID-19–associated pneumonia patients with high CRP levels is likely to be effective.

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RheumNow Podcast – Myth Busters (5.21.2021)

Jack Cush, MD

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com

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RheumNow Podcast – BandAids for Rheumatologists (5.14.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com - a website for rheumatologists, by rheumatologists.



We love Rheumatology!

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Put out cigarettes around others! 👉passive smoking in childhood & adulthood⬆️RA risk 👉RA occurs earlier for passive smoking in childhood 👉passive smoking can cause citrullination in genetically proned subjects b/f 1st Sx's Dr. Y Nguyen Abstr#OP0012 #EULAR2021 @rheumnow https://t.co/ZoIumNQQAf
k dao KDAO2011 ( View Tweet)
Potential rheum board question... True or False? MUC5B is a promoter variant that can increase the risk for ILD in RA Dr. A Palomaki - winner of #EULAR 2021 Abstr award #OP0007 @RheumNow https://t.co/6xKHgXSJ29
k dao KDAO2011 ( View Tweet)
ILD in RA is a killer! @eular_org abst OP0099 Admin day from France claims database. ILD was clinically dx in 2.5% & had 3X mortality. Low prevalence compared to some studies of 6% so maybe worst cases but Impt cause of excess death in RA @RheumNow @eular_org @jeffsparks https://t.co/mPfpPSHxsd
Janet Pope Janetbirdope ( View Tweet)
To clot or NOT? Real world data usually show no ⬆️ VTE in RA with #Jaki compares to other advanced therapies. Diff from high CV risk pts in Oral Surveillance where Tofacitinib had higher VTE vs TNFi @AbbVie symposium @eular_org #EULAR2021 @RheumNow Hard to reconcile diff risk. https://t.co/AWY2zZPSIb
Janet Pope Janetbirdope ( View Tweet)
Hands-Down Rheumatology - Mechanics hands - rough, thickened/caloused, cracks/fissures; seen in 20-70% of dermatomyositis; associated with the anti-synthetase syndrome, but also w/ lung dz and amyopathic DM https://t.co/bkCI3SUXNh https://t.co/jrOGkKAm9z

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast – Heart, Lung & Liver (5.28.2021) Dr Jack Cush reviews the news and journal reports from this past week on RheumNow. https://t.co/a9fvgaJVnQ https://t.co/r3nbf2Ftdb

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Dr. John Cush RheumNow ( View Tweet)
Study of National inpatient sample database (2015 to 2017) showed the frequency of atrial fibrillation in rheumatic disease (RD) pts finding that AF frequency highest in gout followed by vasculitis, and PMR. RD Mortality was 2 fold higher with AF. https://t.co/enno6hrKOI

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Dr. John Cush RheumNow ( View Tweet)

Pirfenidone, studied in 127 pts w/ CVD/CTD ILD, fibrotic interstitial pneumonia, chr hypersensitivity pneumonitis, & asbestoslung fibrosis. Pirefenidone had significantly less FVC% decline compared with placebo (p=0·043) https://t.co/H1s6ut4NhG

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Dr. John Cush RheumNow ( View Tweet)

News Feature: CV Risk Decreased with Certain DMARDs in Rheumatoid Arthritis A large prospective cohort study examined the comparative risks of CVD in patients with RA and found that, MTX, ABA & TNFi use were associated w/ a decreased risk of CV events. https://t.co/uQbtB76Hgy https://t.co/ftc5ys9C58

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Dr. John Cush RheumNow ( View Tweet)
Cohort analysis of 251 SLE patients with and without new-onset arrhythmia (taken from 2499 incident SLE Taiwan claims data). Plaquenil use showed no increased risk of arrhythmia (adj OR = 1.49; 0.98-2.25) or ventricular arrhythmia (adjOR =1.02). https://t.co/vkTi3X7hiM

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Dr. John Cush RheumNow ( View Tweet)

RNL 2021: Pneumonia and RA - Dr. Jack Cush Did you miss #RNL2021? Our great panels are now available to watch on the site. https://t.co/1TR7fmdLq2

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis (11 RCTs, 19 registries) of Pulm arterial HTN assoc. w/ CTD (w/ 1,267 & 4,008 CTD-PAH pts), showed Investigational Rxs reduced morbidity/mortality by 36%. CTD-PAH survival was lower (62 vs 72%) @3yrs, but improved after 2010 (73 vs 65%) https://t.co/0BkO70AQfi

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Dr. John Cush RheumNow ( View Tweet)

Did you miss #RNL2021? We'll be sharing them on the site. RNL 2021: Interstitial Lung Disease in RA - Dr. Jeff Sparks ( @jeffsparks ) https://t.co/0Z5PsWyMFH

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Dr. John Cush RheumNow ( View Tweet)

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