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RA: Still a Clinical Diagnosis

d MedPage Today

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease of the joints, characterized by pain, swelling, and ultimately, if inadequately treated, joint destruction. Despite recent advances in laboratory testing and imaging, the diagnosis of RA remains a clinical one, according to experts.

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Positive Results from the DOA (Duloxetine in OsteoArthritis) Study

d Jack Cush, MD

A pragmatic, open-label trial of osteoarthritis (OA) patients demonstrated that adding duloxetine treatment seems to be beneficial for end-stage knee OA patients with neuropathic-like symptoms (at risk of central sensitization).

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RheumNow Podcast - RWCS 2022 Roundup (2.19.2022)

d Jack Cush, MD

Drs. Jack Cush and Artie Kavanaugh review the highlights of the RWCS (Rheumatology Winter Clinical Symposium) from Maui.


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Prevent NSAID GI bleeding or perforation? Korean study (n=92K) shows (vs non-prophylaxis) PPI and COX-2 inhibitors associated with 64% and 74% reduced risk. COX2 = PPI +nsNSAID. H2-receptor antag. did not reduce the risk https://t.co/VJX5nAftMf

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144 SLE pts from the SLICC cohort were studied showing that a majority (61.2%) scores consistent with depression over 4 yrs; also an inconsistent association between disease activity and depression in multivariate analysis https://t.co/Js5jB6hlox

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Watch: Treat to Target Strategy in RA: Dr. Dylan Lee at RWCS22 https://t.co/QExalESU2q https://t.co/cqzL4FYOUl

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Watch: COVID-19 Triggered Anti-MDA-5 Antibody: Innocent Bystander or Culprit? https://t.co/4MtPFM3jvS

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Late Onset Scleroderma Renal Crisis: A Case Control Analysis - Dr. Yoon Qiu at RWCS 2022 https://t.co/G1M7Lzhk7P https://t.co/hPRL8WFdUf

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Did Your Specialty Choose You? Why did I end up a rheumatologist? Circumstance, personality types, horoscopes or what? A current study in BMJ sheds light on why. https://t.co/vlO5Z8Bu60 https://t.co/y75EsGbMFF

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C.D.C. Proposes New Guidelines for Treating Pain; the main msg - use "nonopioid therapies” for chronic & acute pain, including gabapentin, ibuprofen, PT, massage and acupuncture., https://t.co/vJeGeq8mHz

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CSF aptamer (short nucleic acid sequences) discovery of neuropsychiatric lupus pts finds increase in few CSF proteins that are discriminatory -- CSF Lipocalin-2, M-CSF, IgM and complement C3, the latter assoc w/ acute confusional state. https://t.co/Mvp2U8DMh8

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Using whole gut scintigraphy & gastric emptying studies on 97 systemic sclerosis pts, researchers found 35% had gastroparesis, and these pts also had abnormal transit thru out the GI tract. High anti-CENP-B titers assoc w/ slower gastric emptying https://t.co/lQgQe5Uo9H

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ICYMI: Dr Steen's recipe to dealing with digital ulcers.#RWCS2022 @RWCSmtg https://t.co/fPblrfaFbS https://t.co/rX0hZ7rKl9

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ICYMI: Dr Artie Kavanaugh presents comparison of targeted therapies in different inflammatory disorders. #RWCS2022 @RWCSmtg https://t.co/P4SzIrWzYJ https://t.co/wnf3vnG4xc

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ICYMI: Retrospective study of 98 patients with X-linked agammaglobulinemia (XLA) shows arthritis seen in 46% - more oligo- than polyarthritis, affecting . Knee, hip, and ankle. IVIG response rates around 70%; many w/ arthritis had missense mutation https://t.co/qT49OXLyKU https://t.co/Drz1poV1AH

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ICYMI: Voriconazole-induced synovitis, enthesitis and periostitis described in woman treated for invasive aspergillosis. She had polyarthralgias, synovitis, and periostitis on xray. Voriconazole prev. caused periostitis; now drug induced arthritis? https://t.co/6HfLGIaEsU

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Best treatments for NAFLD? WEIGHT loss, but E, pioglitazone, stations, bariatric surgery. And multidisciplinary approach @UmaMahadevanIBD @RWCSmtg https://t.co/ubdFfOrWIu
Dr. John Cush RheumNow ( View Tweet)
NAFLD is increased in #RA. Risk factors include male, BMI, MTX dose, inflammation. @UmaMahadevanIBD @RWCSmtg #rwcs https://t.co/V94aaO5vEH
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When to suspect an interferonopathy (when suspected you should offer an autoinflammatory panel from https://t.co/F9bat3YS1d) #RWCS2022 @RWCSmtg Dr. Susan Shenoi https://t.co/qUts9X8gwJ

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Interferonopathies may respond well to JAK inhibitors. #RWCS2022 @RWCSmtg https://t.co/X64iRs8fNt
Dr. John Cush RheumNow ( View Tweet)
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