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CRTAC1- a Novel Biomarker for Osteoarthritis
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EurekAlert!
Scientists at deCODE genetics a subsidiary of Amgen report in Arthritis & Rheumatology that a novel plasma protein (cartilage acidic protein-1; CRTAC1) is a potential biomarker of osteoarthritis (OA) through its association with OA risk and progression to joint replacement.
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Primer on Clinical Trials
In this week's special podcast, Dr. Jack Cush offers a primer on rheumatology clinical trials, answering the question: should you be involved in research and clinical trials in rheumatology?
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EMA CHMP issued a positive opinion on the safety of Filgotinib, a selective JAK1 inhibitor, based on testicular safety data from the MANTA & MANTA-RAy studies. Gilead withdrew filgotinib from US market w/ FDA concerns on testicular safety in 12/20 https://t.co/38xOWb1zJi https://t.co/jPUy6H1QQN
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Dr. John Cush RheumNow ( View Tweet)
Urine proteomics on 54 SLE pts in the Belimumab–Lupus Nephritis trial, compared responders (n 31) v non-responders (n 22), on BEL or SOC. Reduction in urinary CD163 was strongly associated with complete renal response @wk52 & CD23 @wk24 https://t.co/PrXaJq6h0E https://t.co/IWREF9VmZ8
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Dr. John Cush RheumNow ( View Tweet)
A Review of AOSD - Adult - Onset Still's Disease
https://t.co/VvWX5t3WPY
@Stills_Now https://t.co/uEoCjhViRP
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Dr. John Cush RheumNow ( View Tweet)
In this week's special podcast, Dr. Jack Cush offers a primer on rheumatology clinical trials, answering the question: should you be involved in research and clinical trials in rheumatology?
https://t.co/yuCAmwsoAY https://t.co/vC835UUxzI
Links:
Dr. John Cush RheumNow ( View Tweet)
Do you renal Bx your #SLE pts? Study of 277 SLE pts w/ US-guided percutaneous renal bx showed bleeding complications post biopsy to be 19.9% (minor 13%; major 7%); risk higher w/ thrombocytopenia (OR 7.12)low eGFR (OR 3.5) https://t.co/vYYChuGdSN https://t.co/kULTEnNYC9
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Dr. John Cush RheumNow ( View Tweet)
NEJM: 70 yoWM w/ 3-wk temporal headaches, jaw pain with chewing, temporal artery tender and thickened, but NO vision Sxs. a 15, CRP 24 mg/L. and Doppler US showed “halo sign” . Temp art Bx confirmed the Dx of GCA https://t.co/ayPcVKctEA https://t.co/g3iP0Akbzs
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Dr. John Cush RheumNow ( View Tweet)
Co-administration of MTX with Folic Acid on the same day did not reduce efficacy compared to FA application one day after MTX. (based on AIA was induced in female Lewis rats) https://t.co/WBT5BOBPqz https://t.co/bP6O24kgXy
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Dr. John Cush RheumNow ( View Tweet)
No Special Heart Risk With JAK Inhibitors, Study Finds
Patients taking JAK inhibitors for RA experienced similar cardiovascular outcomes as those using the TNF blocker adalimumab (Humira), analysis of French national registry data indicated.
https://t.co/Ai3xTPcoO8 https://t.co/TuMaQMWepj
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Dr. John Cush RheumNow ( View Tweet)
Arthritis Clinical Trials Comparison Grid
https://t.co/BEvMKU1WEE https://t.co/2TpxMbWE7h
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Dr. John Cush RheumNow ( View Tweet)
An incredible opportunity for a free Rheumatology Review course hosted by the Pakistan Rheumatology Society
-Event is virtual and registration is free
-Course starts tomorrow 10/16 at 1:30 PM Pakistan time (5:30 AM ET)
See below for details👇🏼👇🏼👇🏼 https://t.co/tHeFwRZHcG
Dr. Laura Lewandowski LauraLewMad11 ( View Tweet)
Sjogrens - Dx tips, myths & mistakes:
• SS not rare; affects 1 in 400
• 95% female, but SS is more severe in men
• African Americans have a severe systemic phenotype
• Asians report dryness Sxs
• Smoking & alcohol intake often avoided by SS pts
https://t.co/f4C0eYv9Ee https://t.co/OOEXfH6jQs
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Dr. John Cush RheumNow ( View Tweet)
Biomedical researchers are at their most creative/innovative EARLY in their career. Study based on 5.6 million papers (1980 to 2009). While least innovative drop out early; in the remaining, innovativeness tends to decline over their career.https://t.co/jXxkEKnl8o https://t.co/mGPokRjkaP
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Dr. John Cush RheumNow ( View Tweet)
Intravenous Immune Globulin in Dermatomyositis
Few drugs have been studied well in the treatment of dermatomyositis (DM) and only recently has intravenous immune globulin (IVIG) been granted FDA approval for the treatment of DM, based on this trial.
https://t.co/8QeEzX8Eqm https://t.co/hUVLUQJjN6
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Dr. John Cush RheumNow ( View Tweet)
In this week's special podcast, Dr. Jack Cush offers a primer on rheumatology clinical trials, answering the question: should you be involved in research and clinical trials in rheumatology?
https://t.co/bnf9RyGJWV https://t.co/Md2TPN70hQ
Links:
Dr. John Cush RheumNow ( View Tweet)
Rheumatology Salaries and Career Choices
A recent Doximity report shows how rheumatology salaries increase by years in practice. Rheumatologists tend to earn their highest salaries after gaining 30-39 years of experience.
https://t.co/wxWQruIlu9 https://t.co/gUsIffoHn6
Links:
Dr. John Cush RheumNow ( View Tweet)
Popular Post: 2022 New ACR Guidance on Glucocorticoid-Induced Osteoporosis (GIOP)
The ACR has updated this guideline and includes recommendations on abaloparatide (PTHrP) and romosozumab, which are newly available since the ACR’s 2017 GIOP guideline.
https://t.co/1LEtUvjNUG https://t.co/IYaJzZmg39
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Dr. John Cush RheumNow ( View Tweet)
ACR Announces 2022 Award Recipients
The ACR and the ARP proudly recognizes the recipients of its 2022 Master of the ACR and ARP designations, ACR Awards of Distinction, and ARP Awards of Merit and Appreciation.
https://t.co/sB3IfvFBJD https://t.co/w8J4qFPvpF
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Dr. John Cush RheumNow ( View Tweet)
Do you renal Bx your #SLE pts? Study of 277 SLE pts w/ US-guided percutaneous renal bx showed bleeding complications post biopsy to be 19.9% (minor 13%; major 7%); risk higher w/ thrombocytopenia (OR 7.12)low eGFR (OR 3.5) https://t.co/kYieyYTUuT https://t.co/ZGobCIcW6v
Links:
Dr. John Cush RheumNow ( View Tweet)
