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New Insights into Uveitis in Spondyloarthritis
Uveitis is the most frequent extra-musculoskeletal manifestation (EAM) in Axial Spondyloarthritis (axSpA). The prevalence of uveitis in axSpA is between 25-30%. Up to 50% of patients with an acute episode of uveitis develop recurrent anterior uveitis or iritis.
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ACR21 Best Abstracts We Saw - Day 3 (Monday)
The third day of ACR 2021 took a big leap in online content. Here is a compilation (with links) of presentations were the “ACRBest” as seen by our RheumNow faculty.
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#ACR21 Ab#1681: ATI-450- MK2 Inhibitor
⭐️Downstream MK2 mediated inflamm drive of p38.
⭐️Hope this would avoid tachyphylaxis in p38 inhibitor meds
▶️Phase2a study in 19 pts: Well-tolerated (SEs: UTI, ventricular extrasystole), good 12 week data
@Rheumnow https://t.co/6lo7zPJUpx
Links:
Eric Dein ericdeinmd ( View Tweet)
Watch my video summary of abstracts #0380 and #0381 presented at the #ACR21 on #SickLeave and #WorkDisability in #axSpA by @ElenaNikiUK and colleagues.
@RheumNow https://t.co/HWEyPoPJi0
Mrinalini Dey DrMiniDey ( View Tweet)
SELECT-EARLY results for #upadacitinib in #RA
👉🏼UPA better than MTX for clinical response and remission
👉🏼⬆️rates of HZ, neutropenia, CPK elevations
👉🏼No new safety risks identified
Abs#1692 #ACR21 @RheumNow
https://t.co/wJy7MK4pyF https://t.co/YNpE1Axiw0
Mrinalini Dey DrMiniDey ( View Tweet)
For Dr @LianneGensler managing axSpA requires a sundae🍨approach! How cool is that?!😎
This means that we need to take a holistic approach on the management of axSpA - both non/pharmacologic & there's no one magic pill to treat the disease.
@RheumNow #ACR21 #RheumTwitter https://t.co/o0OjcEn16b
sheila RHEUMarampa ( View Tweet)
Sick Leave and Work Disability in Patients with AxSpA: Dr. Mrinalini Dey ( @DrMiniDey) discusses abstracts #0380 and #0381 presented at the #ACR21 annual meeting.
https://t.co/Wm4qpxerYJ https://t.co/6CwPrZjqJT
Links:
Dr. John Cush RheumNow ( View Tweet)
The Influence of Obesity on Choice of Biologic Agent in Rheumatoid Arthritis
Dr. Richard Conway ( @RichardPAConway) reviews an abstract presented at #ACR21.
https://t.co/PkJmpODz8v https://t.co/zuJjofka3B
Links:
Dr. John Cush RheumNow ( View Tweet)
RheumNow’s expanded coverage of #ACR21 meeting is sponsored in part by @bmsnews, @JanssenUS, @Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
great Thieves market
another dx to consider for ? inflammatory arthritis
swelling/stiffness post cold exposure
Microgeodic Disease-digital swelling/pain likely from bone infarction 2/2 to cold induced vasospasm
characteristic x ray/MRI findings on poster
#ACR21 #meded https://t.co/eq0aOlcB7I
Adam J Brown AdamJBrownMD ( View Tweet)
#ACR21 #IgG4 Q&A [Drs Stone/Perugino]
📌܄Igg4 in the blood/tissue is NOT diagnostic bec it can also be seen in others (malignancy..etc)
📌its more the presentation/ organ involvement see acr/eular guide: https://t.co/xBvu4r0TM3 https://t.co/WkiF6KyxGq
LiSa ◡̈︎ rheumarhyme ( View Tweet)
Upadacitinib 56-wk efficacy/safety (mod to severe PsA)
🔹Comparable or ⬆️efficacy vs adalimumab
🔹Efficacy maintained, and 15mg vs 30mg doses similar at 56wks
🔹No new safety findings @ 56wks
🔹🚫inc risk VTE, MACE, cancer vs ada
https://t.co/NlKvBrwDxB
#ACR21 Abst#1345 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Echos in PsA, RA:
🔹Diastolic dysfxn: 52% of PsA and RA (!), controls 5%
🔹Mitral regurge PsA 84%, Ra 53%, controls 10%
🔹Mild pulmonary valve regurge higher in PsA
(Diastolic dysfxn has been seen in prior RA studies)
https://t.co/QCKR5itfYj
#ACR21 Abst1308 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Supporting date for Ixekizumab in PsA with symptoms of axial involvement.
🔹Improvement in QoL (SF-36), ASDAS, BASDAI50
🔹Maintained at 52 weeks
🔹Stricter criteria (younger, ⬆️CRP) showed similar results
https://t.co/QSJLQTxLcW
#ACR21 Abst#3147
@RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Calcium hyperproficiency is a rare complication of vitamin D deficiency, where excess calcium from bone resorption forms complex structures resembling primary teeth.
Neoformed teeth grow on different bones, such as this patient's hand, causing fractures and joint dysfunction. https://t.co/oGYCYkh1WD
Eduardo Valdés-Hevia 🦟 Valdevia_Art ( View Tweet)
Adults with #JIA #uveitis are still affected into adulthood. @Mara_Becker discusses visual outcomes #ACR21 https://t.co/ZBjw1CfSmv
Sheila Angeles-Han STHanMD ( View Tweet)
#ACR21 L06 Comparative Safety of Gout "Treat-to-target" and "Usual Care" Treatment Strategies on Cardiovascular Outcomes Using Observational Data: Causal Inference Approach https://t.co/4qo49lpBrt Video interview (https://t.co/k8PHCPaF1r) https://t.co/D4G2Ylkelm
Links:
Kazuki Yoshida kaz_yos ( View Tweet)
🆕 Updated 2021 ACR Guidance for Adjusting Immunomodulatory Therapy with the COVID-19 Vaccine in Patients with Rheumatic & MSK Diseases
Discussed at #ACR21 COVID-19 Hub!
V4 Link: https://t.co/1SOR9yTQyF https://t.co/PKFKXpLofN
Links:
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)
Prof. Cornelia Weyand wonderfully summarizes the mechanisms behind the premature immune #aging phenotype in #RheumatoidArthritis leading to tissue #Inflammation
🔸defect in mitoDNA repair
🔸expanded rough ER
🔸⬇ protein myristoylation
@RheumNow #ACR21 #RheumTwitter https://t.co/8cyqLscctB
sheila RHEUMarampa ( View Tweet)
Can you stop monitoring eyes in + ANA and/or pauciarticular pt who becomes an adult if no uveitis ever, in last 5 yrs, etc. When can we stop looking? #AVR21 @RheumNow https://t.co/1Ml1BuJD7Y
Janet Pope Janetbirdope ( View Tweet)