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New Insights into Uveitis in Spondyloarthritis

Antoni Chan, MD, PhD

Uveitis is the most frequent extra-musculoskeletal manifestation (EAM) in Axial Spondyloarthritis (axSpA). The prevalence of uveitis in axSpA is between 25-30%. Up to 50% of patients with an acute episode of uveitis develop recurrent anterior uveitis or iritis.

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Puzzle pieces

Axial spondyloarthritis with psoriasis or psoriatic spondylitis

Antoni Chan, MD, PhD

PsA commonly affects peripheral joints. In up to a quarter of PsA patients, the spine may be involved and this is known as psoriatic spondylitis (PsSpA). An important research question is whether PsSpA and Axial Spondyloarthritis (AxSpA) with psoriasis are separate conditions or not. 

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Lab work

Infection or Disease Flare: What Tools Can Help Differentiate?

Olga Petryna, MD

Differentiation between a flare of disease and infection in patients with autoinflammatory (AI) conditions, where fever is the hallmark, can be extremely difficult. Few studies have evaluated potential differentiators; and having such tools would meet a huge unmet need. 

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Watch my video summary of abstracts #0380 and #0381 presented at the #ACR21 on #SickLeave and #WorkDisability in #axSpA by @ElenaNikiUK and colleagues. @RheumNow https://t.co/HWEyPoPJi0

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Mrinalini Dey DrMiniDey ( View Tweet)

For Dr @LianneGensler managing axSpA requires a sundae🍨approach! How cool is that?!😎 This means that we need to take a holistic approach on the management of axSpA - both non/pharmacologic & there's no one magic pill to treat the disease. @RheumNow #ACR21 #RheumTwitter https://t.co/o0OjcEn16b
sheila RHEUMarampa ( View Tweet)
Sick Leave and Work Disability in Patients with AxSpA: Dr. Mrinalini Dey ( @DrMiniDey) discusses abstracts #0380 and #0381 presented at the #ACR21 annual meeting. https://t.co/Wm4qpxerYJ https://t.co/6CwPrZjqJT

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Dr. John Cush RheumNow ( View Tweet)
Findings: 1. 21% of the patients in the Ankylosing Spondylitis Registry of Ireland (ASRI) were unemployed which is higher than their national average. 2. Stong predictors of unemployment were - Male sex and worse disease activity outcome measures(BASMI and ASQoL) #ACR21 @RheumNow

swethaann23 swethaann23 ( View Tweet)

#ACR21 @RheumNow Abst#0359 by Garrido-Cumbrera et al. has mapped out the journey from symptom onset to diagnosis of axSpA across 13 European countries.

swethaann23 swethaann23 ( View Tweet)

#ACR21 @RheumNow Abst#0364 by Wetterslev et al. sought to identify axSpA characteristics of patients tapered off TNFI and showed clinical and radiographic improvement. 🔽52% were tapered off ⭐️The highest predictor of success is a low physician global VAS score

swethaann23 swethaann23 ( View Tweet)

⭐️AxSpA pts with decrease in oral microbial diversity ⭐️Immune response to oral/fecal microbes altered in AxSpA pts. ⭐️HLA-B27 associated ⬆️IgA coated microbes, may contribute to development of AxSpA Abs#0052 https://t.co/NQgm0lpYJj #ACR21 @RheumNow

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Robert B Chao, MD doctorRBC ( View Tweet)

Year 2 f/u on PsA, axSpA, or RA using CT-P13, an infliximab (IFX) biosimilar. Pts either naive to IFX or switched from IFX: 💠IFX-naive: improved disease activity 💠IFX-switched: maintained stable disease 💠No new safety concerns https://t.co/VGBicnq15w #ACR21 Abst#0817 @RheumNow

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Pedro Castillo _Castillo_Pedro ( View Tweet)

Identifying Gaps in axSpA: Lessons from European Map of Axial Spondyloarthritis (EMAS) Dr. Sheila Reyes, ( @RHEUMarampa) discusses the three interesting abstracts were presented by the group of Prof. Marco Garrido-Cumbrera on the EMAS at #ACR21. https://t.co/Q50kEr5WEU https://t.co/5DScK5krtw

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Dr. John Cush RheumNow ( View Tweet)
AxSpA: Geographic Prevalence Association with HLA-B27: Dr. Rachel Tate ( @uptoTate ) Dr. Rachel Tate discusses abstract #0368 presented at the #ACR21 annual meeting. https://t.co/CnIjlWuKjZ https://t.co/vytIdK9CCo

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Dr. John Cush RheumNow ( View Tweet)
Lianne Gensler presenting "Exercise Strategies for Ankylosing Spondylitis". Not all physical activity is similarly beneficial. Learn more now by attending her session at #ACR21! @CherylKoehn @ArthritisNetwrk @EIM_Canada @exerciseworks @PhysioKTBroker @jwhittak_physio @JasminKMa https://t.co/rER3EdCohO
JointHealth ACEJointHealth ( View Tweet)
MRI Imaging in RA and SpA: Dr. Sheila Reyes ( @RHEUMarampa) Dr. Sheila Reyes discusses abstracts #0468 and #0469, presented at the #ACR21 annual meeting. https://t.co/MeVia60BNa https://t.co/WRgCifpioQ

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Dr. John Cush RheumNow ( View Tweet)
A study at #ACR21 by Charite-University Medicine Berlin researchers suggests taking tumor necrosis factor inhibitor (TNFi) #biologics earlier in the course of disease could slow down spinal progression in #AxialSpondyloarthritis patients. https://t.co/lDkaMkOcez
CreakyJoints.org CreakyJoints ( View Tweet)
#Uveitis is the most ⬆ freq xtra-articular manifestation in axSpA. What factors are assoc'd w/AAU attacks? 👁‍🗨Active disease 👁‍🗨History of AAU Bottomline: Treat axSpA, treat uveitis = better outcomes. @RheumNow #ACR21 abs1314 https://t.co/O0kHulwJoP
sheila RHEUMarampa ( View Tweet)
axSpA and Uveitis Uveitis 🔼 in HLA-B27; Disease duration; Latin American pts 🔽 in Psoriasis ⭐️Uveitis was not significantly different in axSpA vs pSpA Recurrent Uveitis 🔼disease duration and body mass index (BMI) Abst #1307 #ACR21 @Rheumnow https://t.co/QDg8tOPgir
swethaann23 swethaann23 ( View Tweet)
Emerging Therapies in Spondyloarthritis: A Promising Pipeline by Dr. Olga Petryna (@DrPetryna ) #ACR21 https://t.co/9ggUAh0YJe https://t.co/WHpQp3GYBe

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Dr. John Cush RheumNow ( View Tweet)
Knowledge Bowl at #ACR21 ⭐️Which HLA allele confers an increased risk for anterior uveitis and inflammatory sacroillitis? ➡️HLA-B27 @RheumNow

Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)

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