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Knowledge Bowl at #ACR21
⭐️AMBITION trial data suggested combination of these meds might be more effective than either alone in patients with pulmonary arterial HTN.
➡️Ambrisentan + tadalafil
@RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Knowledge Bowl at #ACR21
⭐️This type of vasculitis is most likely to cause proptosis
➡️GPA
@RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Knowledge Bowl at #ACR21
⭐️This protean tumefactive disease can rarely present with orbital myositis.
➡️IgG4-related Disease
@RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Knowledge Bowl at #ACR21
⭐️This is the most common chest imaging finding in a patient with relapsing chondritis
➡️ Tracheal Stenosis
@RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Dr. K Costenbader #ACR21 #YearinReview will cover important studies for #ClinicalPractice:
👉add on Therapies
👉 the JAK evolution
👉improving clinical care
👉disparities in care
@RheumNow https://t.co/dp1oeYMh8n
TheDaoIndex KDAO2011 ( View Tweet)
👉Voclosporin for SLE: rapid control of proteinuria (50% reduction over 29 days in UPCR w/o high side effects) @rheumnow #YearInReview #ACR21
Are you all starting to use this drug now? It has helped my patients; pretty well tolerated. https://t.co/zqJRsjnV4n
TheDaoIndex KDAO2011 ( View Tweet)
Dr. K Costenbader #ACR21 #YearinReview add-ons Rx:
👉Avacopan for AAV: new oral C5a inh allowed for remission & prevention of relapse, aggressive pred taper https://t.co/39V3LLOYKZ
TheDaoIndex KDAO2011 ( View Tweet)
Experts (Drs. M Clowse, Sammaratino) limit mAb TNFi 1 month b/f delivery or extend dosing. But, they do dose again for flares. Risk for infection is low based on the PIANO registry. Postpartum, they restart the meds w/in 1 week (vag delivery), 2 weeks C/S @rheumnow #pregnancy
TheDaoIndex KDAO2011 ( View Tweet)
Which of the following would you d/c in the 3rd trimester of pregnancy? #ACR21 #Pregnancy @rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
Dr. M Clowse (on HCQ during pregnancy):
👉All pregnant women get HCQ 400 mg/day regardless of how big they are (she does not dose based on mg/kg/d)
👉with maternal metabolism/volume distrib, levels are low.
#ACR21 @rheumnow #pregnancy @drbags71 https://t.co/dZtFLdKOvk
TheDaoIndex KDAO2011 ( View Tweet)
Is holding MTX during breastfeeding overblown?
@MotherToBaby data showed that infants get 0.4% of mom’s dose 24 hrs post-MTX dose. Skip breastfeeding 1 day post-MTX may be safe. Consider monitoring infant CBC. Studies needed to follow infants longitudinally #ACR21 @rheumnow https://t.co/ikJvkk5BjI
TheDaoIndex KDAO2011 ( View Tweet)
Dr. Chambers review @MotherToBaby prospective data on HCQ use in pregnancy (n=279):
👉no major defects (regardless of dose)
👉no oral clefts
👉SGA slightly lower in exposed group b/c of underlying dz
👉no case of retinopathy in babies after 1 year f/u @rheumnow #Pregnancy https://t.co/vw2eryFgro
TheDaoIndex KDAO2011 ( View Tweet)
Dr. Chambers reviewed @MotherToBaby data of pregnant rheum women during the pandemic noted:
⬆️EtOH use in pregnancy,
⬆️stress, anxiety, depression
⬆️obesity
⬇️likelihood to get prenatal care
#ACR21 @rheumnow #RheumPregnancy https://t.co/GCYCIuiunS
TheDaoIndex KDAO2011 ( View Tweet)
#GreatDebate: add on BLMB vs. VCS to MMF for LN
Dr. Petri argues for BLMB b/c:
👉cost is less
👉better adherance
👉not good for class V
👉voclosporin had greater nephrotoxicity
👉insuff data in pregnancy, but not contraindicated like VSC #ACR21 @rheumnow https://t.co/mk2eXwkxcG
TheDaoIndex KDAO2011 ( View Tweet)
#ACR21 #GreatDebate: Dr. Rovin argues for VCS add to MMF b/c:
👉fewer side effects than legacy CNI
👉elevated in creatinine related hemodynamic reversible effect
👉did increase BP (but controllable)
@rheumnow (2/2) https://t.co/mmWp0sBveT
TheDaoIndex KDAO2011 ( View Tweet)
💻 Telemedicine: would you rather have a telephone or a video clinics? Non inferiority RCT shows 80% satisfaction rates and phone-only non-inferior to video visits. I would have expected patients to prefer video visits 🧐 #ACR21 #Abst0112
@RheumNow https://t.co/klgMJ6EthH https://t.co/17ffTAZCfv
Aurelie Najm AurelieRheumo ( View Tweet)
Data science for the dumbs. Very informative talk from Dr Jamie Collins! Surely helpful for me. A good way to decide on the best supervised methods for data analysis in machine learning is to separate according to our goal: to explain or to predict? #ACR2021 @RheumNow https://t.co/J0j6VMkoTV
Aurelie Najm AurelieRheumo ( View Tweet)
Don't forget to discuss Influenza vaccination w/ your RA patients! Higher concerns about RA medications and low necessity of vaccination beliefs associated with a ⬇️ likelihood of vaccination and suboptimal vaccine coverage.
#ACR21 @RheumNow #Abst0141 https://t.co/c5GthZxh3n https://t.co/4Nt92CHFzV
Aurelie Najm AurelieRheumo ( View Tweet)
Our Panel discussion on highlights of #ACR21 Day1 held live yesterday with great colleagues from @RheumNow faculty is now available online! 👯♀️ @RichardPAConway
@Yuz6Yusof @bella_metha @_Castillo_Pedro https://t.co/ulZTNNeqKf
Aurelie Najm AurelieRheumo ( View Tweet)
Abst#271 #ACR21. RA activity predicts left ventricular mass change in pts without CVD
⭐️35% had abnormal LV geometry at baseline TTE
⭐️55% at f/u TTE 3-6 years later
⭐️Increase in concentric remodeling on LV
@Rheumnow https://t.co/uHnqITcTy9 https://t.co/KmV8volVwd
Links:
Eric Dein ericdeinmd ( View Tweet)