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#ACR21 Abst#0276:
Pulse pressure (PP) = Systolic BP - Diastolic BP, measures arterial compliance
⭐️RA: higher PP than controls
⭐️PP was independent risk factor for subclinical atherosclerosis
▶️ Look at the vitals, we have this at every pt visit!
@Rheumnow https://t.co/KZaf1AwO6Q https://t.co/kN4xGxWiV9
Links:
Eric Dein ericdeinmd ( View Tweet)
Before the Great Debate:
Next step for Lupus Nephritis?
#ACR21 @Rheumnow
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Great Debate: Voclosporin vs Tacro?
⭐️Voclosporin has carbon bond extension, changing how voclosporin binds to calcineurin.
⭐️Consistent dose-response prevents need for drug monitoring
⭐️Increases potency and results in improved metabolic profile
@Rheumnow https://t.co/cY93st7754
Eric Dein ericdeinmd ( View Tweet)
Dr. Rovin at #ACR21 Great Debate:
▶️ Disagrees with Dr. Petri that GFR changes are caused by hemodynamics and is temporary, and non-nephrotoxic
▶️ Voclosporin + MMF is safe
@Rheumnow https://t.co/TxDyprnZ5u
Eric Dein ericdeinmd ( View Tweet)
Personalize decision points in belimumab vs voclosporin @jhrheumatology Dr. Petri
▶️ What is the outcome you are most interested in? GFR?
▶️ Is there extra-renal lupus
▶️ Infection risk
⭐️Ultimately, need biomarkers to know who will respond the best
@Rheumnow #ACR21 Great Debate
Eric Dein ericdeinmd ( View Tweet)
Enjoyed the @Rheumnow daily panel - #ACR21 day 3 is in the books!
https://t.co/Wp48PHRCHn
Eric Dein ericdeinmd ( View Tweet)
VEXAS plenary abst#1426 #ACR21 83 patients
🎙️vast majority mutations in p.MET41
Worse mortality when:-
▶️valine mutations on p.MET41
▶️ear chondritis
▶️being transfusion dependent https://t.co/qnA2lPn5yR
Bella Mehta bella_mehta ( View Tweet)
Pain in #spondyloarthritis is complex and multifactorial. Study of nearly 3000 patients, higher pain intensity was associated with working life impairment, spinal stiffness, education, gender, depression, anxiety and sleep @RheumNow, #ACR21 and Abst#0360 https://t.co/xEVI4L0Chw
Dr. Antoni Chan synovialjoints ( View Tweet)
There remains a need to increase knowledge and awareness of #axialspondyloarthritis in this US study of nearly 200 primary care physicians, less than half of the time were IBP symptoms, psoriasis, HLA-B27, CRP or MRI checked @RheumNow, #ACR21 Abst#0370
https://t.co/6Uyy45OEYZ
Dr. Antoni Chan synovialjoints ( View Tweet)
Abst0242 #ACR21 @RheumNow FROST: 1st line Rx of SJIA 73 pts. two study arms: biologics & GC/MTX arm. In biologic arm 14% IL-1i switched to IL-6i, 0% from IL-6i to IL-1i. 50%GC/MTX eventually initiated biologic therapy . 57% of pts d/cGC use, and 75% had cJADAS-10 score ≤ 2.5 https://t.co/vH0AnocTr2
Olga Petryna DrPetryna ( View Tweet)
Abst0357 #acr2021 @rheumnow Irish registry concludes higher level of unemployment in axSpA pts associated w/high disease activity, poor quality of life & worse spinal mobility https://t.co/GsGPLOoWsk
Olga Petryna DrPetryna ( View Tweet)
Abst0369 #acr2021 @rheumnow #acrbest ⬆️ level of pregnancy complications in axSpA in Irish registry. 41.9% complicated, 11.4% pregnan w/multiple complications. Miscarriage 20.5%. Amongst live births 10.8% c-section, preterm 11.4% . NICU admiss11.4%. ⬇️ breastfeeding rate at 33.7% https://t.co/plF8fykCKT
Olga Petryna DrPetryna ( View Tweet)
Abst0909 #ACR21 @RheumNow #acrbest real life study pinpoints higher disease burden, severity of depressed mood & higher Mean ASAS-HI in F pts w/AS. secukinumab improved disease activity, global functioning and severity of depressive mood in AS patients in both men and women https://t.co/fQycXY1aed
Olga Petryna DrPetryna ( View Tweet)
Great Debate on Voclosporin vs. Belimumab in Lupus Nephritis therapy.
Dr. Petri argues Belimumab has less potential AE including infections, cardiovascular risk, malignancy potential. No drug-drug interactions.
What would you choose?
#ACR21
#ACRBest
@RheumNow https://t.co/FywUp3zCj2
Robert B Chao, MD doctorRBC ( View Tweet)
Differences in secukinumab pain response in AxSpA pts based on HLA-B27 sub-types.
Homozygous group = more uveitis, arthritis, enthesitis, male
Abs#917
#ACR21 @RheumNow
https://t.co/3TL9PdS4xx https://t.co/QQ0Tdye1Z9
Robert B Chao, MD doctorRBC ( View Tweet)
EDUCATE! 📣EMPOWER!📣
Prof FMiller shares adaptive measures against predicted impacts of #climate change on rheumatic diseases.
📍We all have a role to play in this.
@RheumNow #ACR21 #MedTwitter #RheumTwitter https://t.co/asJcnm104k
sheila RHEUMarampa ( View Tweet)
An important slide showing how UV radiation affects #Immunity
🔅suppress APCs
🔅promotes #cytokine production
🔅inhibits cytotoxic & memory T cells
🔅⬆ monocyte recruitment 👉⬆ IFN
🔸⬆UV exposure, ⬆ risk of dev't/flares of #lupus, DM
@RheumNow #ACR21 #climatechange https://t.co/e9glxfy6wR
sheila RHEUMarampa ( View Tweet)
Interim analysis of AURORA 2 Extension study:
🦋Voclosporin maintained meaningful reductions in UPCR and eGFR remained stable until month 30.
🦋No unexpected new AEs
Promising results!
@RheumNow #ACR21 #ACRBest abs1425 https://t.co/hBB6k0bDYb
sheila RHEUMarampa ( View Tweet)
Identifying Gaps in axSpA: Lessons from European Map of Axial Spondyloarthritis (EMAS)
Dr. Sheila Reyes, ( @RHEUMarampa) discusses the three interesting abstracts were presented by the group of Prof. Marco Garrido-Cumbrera on the EMAS at #ACR21.
https://t.co/Q50kEr5WEU https://t.co/5DScK5krtw
Links:
Dr. John Cush RheumNow ( View Tweet)
CARRA survey in SAID pts reported no change in flare frequency w/ COVID19 but many had reduced intensity of fevers during flares. Majority of pts reported mild to moderate symptoms w/ 1/3 had lingering COVID19 symptoms. Abs 1083 #RheumNow #ACR21 @RheumNow https://t.co/qbfsqvXutt https://t.co/6u33VDIexY
Dr. Rachel Tate uptoTate ( View Tweet)