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Can tender and swollen joint counts work in a telemedicine world?
In a world where telemedicine and virtual care are not going away, is there value in patients assessing their own tender and swollen joints?
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#ACR21 Abs#1225: B/L Extracell Matrix Biomarkers predict ABA response in MTX-naive, +ACPA early RA
⭐️ECM biomarkers predict SDAI remission or DAS28 w ABA+MTX vs PBO+MTX.
⭐️⬆️CTX1 biomarker predicts efficacy endpts for ABA+MTX
https://t.co/7wHQefb5D4 @Rheumnow
Links:
Eric Dein ericdeinmd ( View Tweet)
Wk 12 disease activity predicts wk 24/26 remission/low disease activity with #upadacitinib 15mg in MTX-naïve or inadequate responders to MTX and/or TNFi pts.
≥50% improvement in SJC/TJC at Wk 12 was assoc with wk 24/26 remission/low disease activity.
Abs#1237 #ACR21 @RheumNow https://t.co/PAaCe5MAcu
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 - Starting soon - The Gift of Gab! with @BayviewMedicine @jhrheumatology Jason Liebowitz moderating Communication for the Physician with @Wharton Janet Zeide. Learn about the RHEUM acronym for speaking! @Rheumnow https://t.co/wcgFUBcZeX
Eric Dein ericdeinmd ( View Tweet)
EULAR update on vaccines. HZ vaccine safe with csDMARDs and TNFα blockers. Reduced cell immune response after 1 year. Assess Varicella Abs if exposure unknown. Non-live recombinant subunit adjuvant zoster vaccine may be a game changer @RheumNow #ACR21 8M101 https://t.co/PTLqYGRIGf
Dr. Antoni Chan synovialjoints ( View Tweet)
Innovative!
Self-home fetal heart rate monitoring by the mother is feasible, accurate, effective for those with +anti-Ro/SSA Ab.
The study is still recruiting https://t.co/9BFihsgW5A Abst#1464 #ACR21 @rheumnow
https://t.co/ggmOpSGdZk
Links:
TheDaoIndex KDAO2011 ( View Tweet)
RheumNow’s expanded coverage of #ACR21 is sponsored in part by @Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
Abs#1036: illness-related uncertainty significantly correlates with #depression, #anxiety, and sickness impact in patients with autoimmune #rheumaticdiseases.
Particularly strong associations with #AAV and #SSc.
#MentalHealth #ACR21 @RheumNow
https://t.co/SiV9fst3Bh https://t.co/w8VRQHdAJC
Mrinalini Dey DrMiniDey ( View Tweet)
⚡️A new biomarker of structural progression in RA? Plasma levels of CXCL13 ⬆️ @ baseline vs. ctrl and ⬇️ (p< 0.0001) after 1 yr treatment in a eRA cohort. Levels above 85pg/ml ⬆️ x5 risk of > severe radiographic status at 11yrs. @RheumNow #ACR21 #Abst1204 https://t.co/LnkayR1YrY https://t.co/W0xsgGuUDW
Aurelie Najm AurelieRheumo ( View Tweet)
#ACR21 Abst#1204. CXCL13 predicts long-term radiographic status in early RA
▶️ early RA has ⬆️ CXCL13, and ⬇️ w treatment
⭐️CXCL13 was best predictor of long-term radiographic destruction - better than DAS28CRP and CRP
@Rheumnow https://t.co/ydYRbKMBZ2 https://t.co/qinEFb86Az
Links:
Eric Dein ericdeinmd ( View Tweet)
Increased risk of vertebral fractures in PsA pts
OR 2.09 from meta-analysis and systematic review
Abs#1304
#ACR21
@RheumNow
https://t.co/0IazVBGHsF https://t.co/YrPMh1TZ6U
Robert B Chao, MD doctorRBC ( View Tweet)
#ACR21 Abst#1229: Does BMI influence efficacy of SC (fixed dose) vs IV (body-wt adjusted) ABA in RA?
⭐️No difference between SC and IV ABA by BMI
⭐️BMI impacts response to ABA as >2nd line therapy and retention, but no difference bw dosing
https://t.co/LqfZvLhBzU @Rheumnow
Links:
Eric Dein ericdeinmd ( View Tweet)
Is #calprotectin the new ESR/CRP?
👉🏼SLR finds calprotectin correlates w/ ultrasound synovitis in RA
👉🏼In some studies, it was a better biomarker than ESR/CRP
👉🏼It can distinguish ultrasound remission from subclinical synovitis
Abs#1207 #ACR21 @RheumNow
https://t.co/ADkRBq5KoG
Mrinalini Dey DrMiniDey ( View Tweet)
CATCH cohort: PT CDAI and MD CDAI correlate good to strongly at 3 and 6mo in patients with no non articular pain or w/regional pain but 🚨 NOT in pts w/ widespread pain! We should find alternative remote DA measures for this pop. #ACR21 @RheumNow #Abst1202 https://t.co/LsCtsfXsN1 https://t.co/gjeGxBA0HB
Links:
Aurelie Najm AurelieRheumo ( View Tweet)
My video summary on this important piece of work by @Sineadm15 is now available to watch on @RheumNow:
https://t.co/Gh64D4PADw
#ACR21 #MentalHealth #Depression #AxSpA https://t.co/EcH4VDs2Xi
Links:
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 Abs#1196: Morning stiffness (MS) in pre-RA arthralgia associates w inflammation
⭐️Arthralgia pts: 14% ACPA+, 34% w MS
MS correlates w ⬆️subclinical synovitis/tenosynovitis on MRI and higher CRP. Duration of morning stiffness correlates
https://t.co/DUhgjbjQIr
@Rheumnow https://t.co/dHl7LuY3ZA
Links:
Eric Dein ericdeinmd ( View Tweet)
We need to be better at identifying and managing #depression in patients with #axspa.
In a group of 70 pts, many had high HADs-D & PHQ-9, with worse disease activity & #QoL compared to those with normal scores.
Abs#1305 #ACR21 @RheumNow
https://t.co/lNoo0HfMcC https://t.co/n7Vyl9L5FR
Mrinalini Dey DrMiniDey ( View Tweet)
Ultrasound in CSA patients:
Retro US cohort 110pts
28.2% w/ 💥Power Doppler synovitis. 36.8% at 6mo evolved to RA among which 100% PD+ vs 25% PD-
PD + predicts evolution to clinical RA (OR 13.1; CI 1.07-161.04)
Easier and less invasive than MRI!
#Abstr1525 #ACR21 @RheumNow https://t.co/MkhWTvnv3L
Aurelie Najm AurelieRheumo ( View Tweet)
TCZ in GCA: one disadvantage is that you can't use CRP+/- ESR for flares
Mavrilimumab in GCA:
- CRP/ESR consistently go up with symptomatic flares
- CRP/ESR up less (cf. placebo), in the absence of Sx flares
More signal, less noise.
phase 2 post-hoc #ACR21 ABST1401 @RheumNow https://t.co/c0lMJMcQv0
David Liew drdavidliew ( View Tweet)
Watch: Lupus Updates: Dr. Michelle Petri
Dr. Michelle Petri offers perspective and insight into lupus related data presented Saturday at the #ACR21 annual meeting.
https://t.co/L7T2mNJVH0 https://t.co/MCQ7nJjCIY
Links:
Dr. John Cush RheumNow ( View Tweet)