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#ACR21 #Abstr0454 Mortality rate in #lupus nephritis ⬇️by 26% from 1999-2019👏. BUT, racial and residence disparities were concerning; worse in Black, Hispanic, Asian, AI/AN vs White and in large central and medium metro. Residential matters! @RheumNow https://t.co/33vN39acuL https://t.co/XMwN2hXJn7
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Possible disease activity biomarkers in axSpA? Neutrophil lymphocyte ratio (NLR) & platelet lymphocyte ratio (PLR) along w/ PROs may be helpful to measure dz activity clinically. More studies needed for proof of concept. Abs 0384 #ACR21 #RheumNow @RheumNow https://t.co/ZXyQHNzqz7 https://t.co/va5fBR9Gnk
Dr. Rachel Tate uptoTate ( View Tweet)
#ACR21 @RheumNow
Abst#0370 by Afinogenova et al.
138 PCP surveyed on Chronic back pain evaluation
▶️58% rarely assess for IBP
▶️40% not comfortable diagnosing AS
▶️70% not comfortable diagnosing axSpA
Contributing to a lack of referral to rheumatology and delay in diagnosis.
swethaann23 swethaann23 ( View Tweet)
Annual age-standardized mortality rate (ASMR) improved from 1999-2015, then worsened 2015-2019:
#ACR21 Abst#0454 @RheumNow https://t.co/mu1xIO7YlI
Pedro Castillo _Castillo_Pedro ( View Tweet)
Race/ethnicity and residence were independent risk factors for LN mortality which was higher in:
➡️Black patients
➡️Those living in central metro areas
#ACR21 Abst#0454 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Prevention study using Abatacept in 100 patients with arthralgia is superior (61%) to placebo (31%) in improving subclinical inflammation in RA at-risk patients (ACPA+, MRI+, Arthralgia+) at 6 months. No new safety issue emerged @RheumNow #ACR21 Abst#0455 https://t.co/DoRItcHfBE
Dr. Antoni Chan synovialjoints ( View Tweet)
Abst0453 #ACR21 @RheumNow integrated phase 2/3 trial results of il23 inhibitor Risankizumab (RZB) in PsA: significant improvement ACR20 at Week 24 (RZB 55.5% vs PBO 31.3%, P < 0.001), secondary endpoint met at HAQ DI, PASI, fatigue score& enthesitis. no new safety signals https://t.co/ZAVgswoXCf
Olga Petryna DrPetryna ( View Tweet)
#ACR21 Abst#0456. Fxnal connectivity, ⬆️ blood-brain barrier (BBB) leakage & cognitive impairment (CI) in SLE
⭐️SLE pts ⬆️♀️, older, caucasian, ⬇️ edu than controls
⭐️CI in longer disease, APS
▶️ SLE CI:⬇️Brain-wide connections, BBB permeability
https://t.co/fen9OYhWhC @Rheumnow https://t.co/DMQfWCqUhh
Links:
Eric Dein ericdeinmd ( View Tweet)
RZB tx resulted in statistically greater improvements in signs/ symptoms of PsA vs PBO and was well tolerated w/ no new safety signals. Plenary Abs 0453 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/c9RJdWlmpO https://t.co/MDbdAhdnIy
Dr. Rachel Tate uptoTate ( View Tweet)
Serum IL-22 levels elevated in axSpA pts in Israeli study. Possible independent biomarker for the differentiation of AxSpA from its non-inflammatory mimickers? Possible target for treatment? Further studies needed. Abs 0385 #ACR21 #RheumNow @RheumNow https://t.co/AUwZFJTlnq https://t.co/WSZ2WjW45W
Dr. Rachel Tate uptoTate ( View Tweet)
Can we stop RA developing? Not previously.
Double-blind RCT:
- arthralgias+ACPA+MRI changes
- but no clinical synovitis
- abatacept for 6m
didn't progress to arthritis: 92% v 65%
improvement in MRI: 61% v 31%
+ benefit to 18m not shown
"provocative"!
#ACR21 ABST0455 @RheumNow https://t.co/TGxCBhk4r9
David Liew drdavidliew ( View Tweet)
New treatments in #psoriaticarthritis Deucravacitinib TYK2 inhibitor selectively mediates cytokine signaling, specific inflammatory pathways (eg, IL-23, IL-12, and Type I interferons) concomitant with clinical symptom improvement @RheumNow #ACR21 Abst#0490 https://t.co/7JZGa5R4eC
Dr. Antoni Chan synovialjoints ( View Tweet)
Functional MRI eval neuro-connectivity in 78 SLE pts
Cognitive impairment occurred in 48%; pts had:
👉longer disease duration
👉likely +LAC
👉abnormal fMRI
👉>blood brain barrier permeability
#ACR21 #Plenary Abstr# 0456 @rheumnow https://t.co/WI5CD73rvM
TheDaoIndex KDAO2011 ( View Tweet)
How about lipoprotein a as a potential biomarker for poor renal outcomes in #lupus?
Results of this study by Dr @CaoilfhionnMD and her group show that ⬆Lp(a) is strongly associated w/ proteinuria, ⬇ eGFR and ⬆PGA.
Interesting🤓
@RheumNow #ACR21 abs0327 https://t.co/MLgJ1tPJMp
sheila RHEUMarampa ( View Tweet)
#ACR21 Abst#0155
⭐︎ Tenosynovitis on MRI hand/foot in ACPA(-) undifferentiated oligo-arthritis pts is predictive of RA
➡️NPV 93%, Se 85%
⭐︎ BM edema not prognostic of RA development
Do you already use MRI to help detect early RA?
@Rheumnow
https://t.co/mpageAYeT2
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
#ACR21
Many faces of cell death
Netosis in APS and #SLE
NETs and APS
🕸️NETs are prothrombotic🕸️ https://t.co/FG3VNbQPzh
Dr. Laura Lewandowski LauraLewMad11 ( View Tweet)
Pts with hospitalization from #SLE often do NOT have a f/u visit within next 2 weeks. 2/3 NO timely fu esp poor, young non-White& do worse. Is it due to fact that no one gets discharge summary or admission note or discrimination or health system prob #abst0464 #ACR21 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Targeting the HUGE dilemma!🎯
#Psoriatic vs Erosive #OA
PsA
👉 Fluffy bone formation(enthesitis of phalanges)
👉 Marginal erosions(vs central)
👉 Many jts in same digit(ray inv)
👉 Periarticular SOFT tissue swelling (dactylitis).
👉 NOT much hand OA
#ACR21 RadiologyBootCamp https://t.co/OQLPoeRLny
Ashima Makol MD AshimaMakol ( View Tweet)
Abstract 0444- Dr. Gupta
⭐️COVAD Study - ❗️18000 global pt survey looking at AE after COVID vaccination in Autoimmune disease
1227 IIM pt total- more injection site pain, headache, rash, fatigue in DM
#ACR21 #ACRAmbassador https://t.co/s4Fc5c9Kln
Veena Katikineni VeenaRheumMD ( View Tweet)
Blood Brain Barrier leakage correlates w/ CNS dysfunction in SLE - study by John Hanley of 78 SLE pts. CNS impaired in 48% SLE (more likely LAC+, APL+) correlated w BBB (10-30%) leaks. #ACR21, Abstr# 0456 https://t.co/DyUB2TU4pS https://t.co/Sd1tr0BF2H
Links:
Dr. John Cush RheumNow ( View Tweet)