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CDC Advises COVID-19 Vaccines for Pregnant Women

d CDC

Today, CDC issued an urgent health advisory to increase COVID-19 vaccination among people who are pregnant, recently pregnant (including those who are lactating), who are trying to become pregnant now, or who might become pregnant in the future to prevent serious illness, deaths, and adverse

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Gout Flare and Treatment Studies Lacking in Severe Chronic Kidney Disease

d Jack Cush, MD

Gout is a common comorbidity amongst those with chronic kidney disease (CKD), with the added challenge of choosing best therapies in the setting of declining renal function.  A systematic literature review notes significant deficiencies regarding the efficacy and safety outcom

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Early Diastolic Dysfunction in Premenopausal Women with RA

d Jack Cush, MD

A two-dimensional/Doppler echocardiography of rheumatoid arthritis (RA) detected premature, clinically quiescent diastolic function.

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Starting Febuxostat During an Acute Gout Flare

d Jack Cush, MD

A randomized controlled trial in gout patients has shown that starting febuxostat during an acute gout flare was without ill-effects and did not prolong the gouty attack.

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Early Antibiotic Use Increases JIA Risk

d Jack Cush, MD

A population based Swedish study of birth records shows that antibiotic exposure in first three years of life to be associated with a future risk of juvenile idiopathic arthritis (JIA), although infections during fetal life or childhood did not increase risk of JIA.

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SENSCIS trial compared 1 yr of nintedanib (NIN) vs placebo in 576 SSc-ILD pts. NIN was more effective (less FVC decline) in 1) α-topoisomerase Ab neg (57.2 vs 30 ATA+), 2) mRSS ≥18 (88.7 vs 26 mRSS<18), & 3) diffuse (57 vs local 25) SSc pts https://t.co/cLuTBDeJD6

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Alendronate may protect against type 2 Diabetes. Data from National Danish Patient Registry, presented at the EASD meeting compared 160k T2DM & 500k controls, T2DM following alendronate adjusted OR=0.64; 0.62-0.66); >8yrs OR=0.47 https://t.co/RYEZodUZtv

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TONIGHT! the ACR is holding a " Just Diagnosed: Now What? Patient Webinar" - this will feature Academy-nominated screenwriter & patient Emily Gordon ("The Big Sick") with Rheumatologist Stuart Kassan, MD, register here: https://t.co/TOCgOuV0Ng

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Analysis of 508 #RA pts (over 10 yrs) in the BeST study shows joint swelling at baseline resulted in half w/ re-swelling later and significantly increased risk of same joint swelling during follow-up (OR 2.37, 95% CI 2.30 to 2.43, p<0.001) https://t.co/a7zH4YRAkq

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PROCEED study of 300 pts with chronic, DXA proven bone loss in half (osteopenia in 39% and osteoporosis in 17%) with higher fracture rates. Such pts should undergo screening for osteoporosis. https://t.co/7fgeAk85vu

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Are you an Expert in Still's disease, Periodic Fevers, FMF or Autoinflammatory Dz? I will add you to our expert referral listing on https://t.co/LYd3dtU295. DM me to get on the list! https://t.co/lt8YMPOpK2 https://t.co/QxXHMvayTG

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U.S. Preventive Services Task Force (USPSTF) reaffirmed its recommendations that pregnant women at a high risk of preeclampsia should take a daily aspirin regimen at the end of the first trimester https://t.co/DiV7p6g8vL

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Finnish Pop study 939 #RA pts shows highest healthcare costs linked to high Dz activity & comorbidity. Clusters: C1) young w/ low costs & activity, C2) chronic pain, disability, fatigue, C3) high cost/dz activity, less pain, C4)comorbidities w/ $$$ https://t.co/Azc35zyA9J

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RA DMARD use gleened from 86 rheumatologists recording Rx choices/reasons on next 12 pts. Total: 1027 RA pts, 621 already on b/ or tsDMARD (68% TNFi, 21% JAKi). ~Half who switched given another TNFi . Reasons: LOE, dz worsening https://t.co/zpjSO25wsh

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EULAR has received reports of tocilizumab shortage in several countries, including Germany, Portugal, Belgium, and Scandinavia. The UK and France are aware tocilizumab concerns, but have not yet reported actual shortages https://t.co/7QpjZTXXAK

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A longitudinal study from Iceland shows an increasing number of native joint infections (NJI), with iatrogenic, postarthroscopic infections being of particular concern. Read more… https://t.co/n82PpZ7a96 https://t.co/j3gzZ9g0QV

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DEA has warned of an increase in illegal counterfeit pills containing fentanyl & methamphetamine. These often look Rx opioids (Oxycontin, Percocet, Vicodin), Xanax or Adderall. DEA seized >9.5 million fake pills (more than last 2 yrs) https://t.co/Y0gJ4XrV1a

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Study Finds U.S. Generic and Biosimilar Savings Totaled a Record $338 Billion in 2020 https://t.co/hPR0nGd6jp

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Biosimilar update: 31 FDA approved biosimilars, but only 60% made it to market. 2015 to 2019, drug spending grew 6.1%, biologic spending grew 14.6%; biologics are 43% of US drug spending. Most biologics at ~30% discount. https://t.co/4paYH8yVLQ

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MMWR shows the safety of a 3rd (booster) dose of the mRNA vaccine to be same as the 2nd dose AEs. V-safe data on 3rd dose (n=12,591) showed local or systemic effects (79% or 74%) to be same as 2nd dose (78% or 76%) https://t.co/LcD0ARlWJ2

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