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COVID Breakthrough Infections with Arthritis and HIV

d MedPage Today

Among immunocompromised individuals vaccinated against COVID-19, solid organ transplant recipients as well as those with HIV and rheumatoid arthritis (RA) were significantly more likely to experience breakthrough infections versus people without immune dysfunction, a retrospective study found.

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New Onset Rheumatic Disorders with COVID-19 Infection

d Jack Cush, MD

The journal Cells has published a review of new rheumatic disorders following COVID-19 infection. Rheumatologists have infrequently noted such events and wondered what is the true incidence or range of possible manifestations.

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Clinical Practice Guidelines for Multisystem Inflammatory Syndrome in Children

d Jack Cush, MD

Multisystem inflammatory syndrome in children (MIS-C) is new and serious complication of COVID-19 that preferentially affects adolescents. A review of proposed management guidelines is compiled in this report, suggesting a unified approach to therapeutic management of MIS-C.

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Autoantibody Associations in Systemic Sclerosis

d Jack Cush, MD

Analysis of two large cohorts of systemic sclerosis (SSc) patients shows a signfiicant minority of patients to have autoantibodies typical of rheumatoid erosive arthrits, but their presence in SSc patients was associated with unique manifestations of SSc. 

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New Onset Rheumatic Disorders with COVID-19 Infection The journal Cells has published a review of new rheumatic disorders following COVID-19 infection. Read more: https://t.co/WdtNQWnGmk https://t.co/Fmoh1Wsvg4

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Risk of Cancer w/ IgG4-related disease (IgG4-RD)? A meta-analysis of 10 studies shows compared to gen population, IgG4-RD has a higher risk of overall cancer(SIR 2.57), esp pancreatic (SIR 4.1) & lymphoma (SIR 69.2); but not lung or gastric cancer https://t.co/EzgMXIdFcL

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MMWR (CDC) reports that In 2019, 12.3% and 10.0% of adults met fruit and vegetable intake recommendations. Fruit intake highest w/ Hispanics(16%), lowest in males (10%). Veggie intake highest ≥51 yrs (12%), lowest w/ low income (7%)https://t.co/fxQszBy7vO

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Clinical Practice Guidelines for Multisystem Inflammatory Syndrome in Children Multisystem inflammatory syndrome in children (MIS-C) is new and serious complication of COVID-19 that preferentially affects adolescents. Read more : https://t.co/3VXU7vEkb7 https://t.co/bWUseG9ogf

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Dr. John Cush RheumNow ( View Tweet)
Infectious mimics of #RA include viruses (Parvo B19, HBV, HCV, HIV, Chikungunya alphaviruses) mycobacterial infections (Poncet's dz, TB, leprosy), bacterial arthritis, brucellosis and Lyme disease. https://t.co/COjPWU8sC5

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Collagen Ab induced arthritis (animal model for RA) may also evolve into a model of axial spondyloarthritis as once induced, they also developed spinal lesions similar to those found in AxSpA. https://t.co/y1J9fNiFQd

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@ACRheum guidance from 2/2021 recc holding HCQ in pts with #COVID19. Are you doing this? We need updated guidances with #Omicron @rheum_cat @LCalabreseDO @CCalabreseDO @RADoctor @RheumNow @JYazdanyMD

TheDaoIndex KDAO2011 ( View Tweet)

ASK CUSH ANYTHING! Have a Rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/7q5sMQuIHj https://t.co/ksCCvzdxka

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Register for RheumNow Live, March 19-20, 2022. You can attend RheumNow Live in person in Irving, Texas - or, the comfort of your own home or office. You can also receive CME credit! https://t.co/CenvwXiYPV https://t.co/ocBDIiF5IB

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New slides available for download! Should I start a podcast? These slides are your notes on how to start a podcast. How and why, with a few suggestions thrown in. https://t.co/Q0owuZdJ2c https://t.co/rHuwKPkH7G

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There have been reports of COVID-19 vaccination causing adult-onset Still’s dz onset. Now a case of AOSD, given the BNT162b2 vax and developing Macrophage activation syndrome w/ ferritin levels of 136,680 µg/l https://t.co/caKef9BGDR

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Safety of COVID-19 Vaccines in Rheumatic Patients A multinational study shows that the use of COVID vaccination in rheumatic and musculoskeletal disease (I-RMD) is safe, well-tolerated with very rare serious adverse events (AEs). https://t.co/d30zbfa0f8 https://t.co/OM6GzAzTvQ

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Cosentyx (secukinumab) was FDA approved for use in pediatric psoriatic arthritis & enthesitis-related arthritis, based on results of the ph III JUNIPERA study. Dosing based on weight (SEC 75 mg sc if 15-50kg; SEC 150 mg sc if 50 kg or more) https://t.co/1nv3iJ7EJ3

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Does COVID Vax reduce adolescent MIS-C risk? In France 77% of teens recv COVID Vaccine by 10/2021. From Sept-Oct 2021,107 MIS-C kids were hospitalized in France; 31% were eligible but not vaccinated. MIS-C risk dropped 91% (0.09) after 1st first vax dose https://t.co/mF0L2VnEoi https://t.co/R33n1FCN3X

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Dr. John Cush RheumNow ( View Tweet)
Of 173 autoimmune inflammatory rheumatic Dz pts w/ respiratory Sx, 46 had Pneumocystis jirovecii. Higher risk of PJP w/ high-dose steroids, recent immunosuppressives, combo w/ CsA, hx of chr lung dz, high LDH, ground glass CXR https://t.co/P8KtC2Hab8

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Study of biologic/ts DMARD switching in 8,398 axial spondyloarthritis pts from 5 Nordic registries showed a low rate of multiple switches (refractory?) over 3 years; ≥3 DMARDs (8%), ≥4 (3%) & ≥ 5 (1%); more w/ women, comorbiditiy & psoriasis https://t.co/ZQDvl6AaZz

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