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More Tea, Less Rheumatoid
A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.
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Early MRI Sacroiliac Improvement with JAK Inhibition
The TORTUGA trial tested filgotinib, a JAK1 inhibitor, in active ankylosing spondylitis (AS) patients and was shown to be both effective and capable of retarding sacroiliac (SI) joint erosions as early as 12 weeks.
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TB rarely causes arthritis; accounts for 1-5% of all TB (10-30% of pulmonary TB) cases. May present as mono/oligoarthritis, tenosynovitis, dactylitis, Spondylitis (Potts disease), reactive arthritis (Poncets dz) or polyarthritis. https://t.co/RpMrRLQbEa
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Safety and Tolerability of Subcutaneous Methotrexate
A large, single-rheum center analysis of oral and SC MTX use in daily clinical practice suggests that SC MTX has fewer drug discontinuations and is better tolerated compared to other DMARD therapies.
https://t.co/TZwZO9j5xd https://t.co/tx9dWoHUj0
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It was a banner week at the FDA; a new drug approval you should know about; a lot of information about pregnancy and safety; and an interesting case plus a question from one of our readers--this and more in this week's podcast. Let's dive in.
https://t.co/5K8ejJ4jj2 https://t.co/RDEM0BMZLC
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Lumbar Spine Decompression Alone is Superior to Decompression with Fusion
https://t.co/EjLoVZaJf5 https://t.co/OJHJl3EWsv
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Can you manage FM without opioids? Study of 698 Fibromyalgia pts from a tertiary center finds 27.1% taking opioids. Opioid associated with longer Sx duration (>3 yrs), increased age, worse functional impairment & pain catastrophizing https://t.co/N1G4ZtkUE5
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Delays in Joint Replacement as JIA Patients Reach Adulthood
https://t.co/EQNZPD8d7o
The JIA category, year of implant, and presence of complications significantly affected implant survivorship. https://t.co/yiD74AElPC
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FDA issued Drug Safety Communication to statin manufacturers requesting they remove strong warnings against statin use during pregnancy. While statins appear in breast milk, they should not be contraindicated, if needed, during Pregnancy https://t.co/AeFwpsLMXT
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Pfizer has another JAK inhibitor - ritlecitinib - shown to be effective (vs PBO) in alopecia areata in the Phase 2b/3 ALLEGRO trial. Ritlecitinib is also being studied in vitiligo, rheumatoid arthritis, Crohn’s & ulcerative colitis. https://t.co/ccx0eRXuTS https://t.co/fApTP7WaYU
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IL-6 Inhibitor Safety Issues-Download now!
https://t.co/rjId76sJ64 https://t.co/QwBJNmrzBf
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In a head to head trial Upadacitinib was superior to Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis. 24wk DBRCT, 924 pts given either UPA 30/d vsDUP 300 EOW. ESI75 response@wk16, UPA 71% vs DUP 61% https://t.co/5cOoosKyao
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New podcast available for download!
https://t.co/5K8ejJ4jj2 https://t.co/Va66dLGrXO
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ICYMI:
Skin Involvement with HMGCR Necrotizing Myositis
The Journal of Autoimmunity reports that anti-HMRCR antibody positive, necrotizing myositis patients frequently have cutaneous lesions, more so than previously reported.
https://t.co/RR07dYIJSr https://t.co/MiaIqvMPaB
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ICYMI:
D-penicillamine Adverse events reported to FDA (1970-2020): dystonia (OR 20.52), drug hypersensitivity (OR 5.42), pancytopenia (OR 10.2), joint swelling (OR 9.07), Renal (OR 6.68), dysphagia (OR 5.05), CHF (OR 4.04), edema (OR: 3.77) https://t.co/8lmYiJo2Tz
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ICYMI:
CRESS – A New Composite Measure for Primary Sjögren's Syndrome
https://t.co/7tvjBvP3g4
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ICYMI:
JRheum review: 40–50% of psoriasis pts have psoriatic nail disease NP). NP is an important predictor of enthesitis, which is associated with the early stages of PsA https://t.co/sEuih3CSgX
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Dr. John Cush RheumNow ( View Tweet)
It was a banner week at the FDA; a new drug approval you should know about; a lot of information about pregnancy & safety; and an interesting case plus a question from one of our readers submitted. This and more in this week's podcast. Let's dive in.
https://t.co/5K8ejJ4jj2 https://t.co/pqCsvYuI96
Links:
Dr. John Cush RheumNow ( View Tweet)
Veterans study gout prevalence rose from 4.2% to 5.8%, 2005 to 2014. 2014, 4.0% of all inpatient/outpatient encounters & 1.3% of hospitalizations were gout related. ULT use remained stable with 46% of gout patients receiving ULT https://t.co/Lmf2mmMddW
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Dr. John Cush RheumNow ( View Tweet)
Skin Involvement with HMGCR Necrotizing Myositis
The Journal of Autoimmunity reports that anti-HMRCR antibody positive, necrotizing myositis patients frequently have cutaneous lesions, more so than previously reported.
https://t.co/RR07dYIJSr https://t.co/f4WdkRZWpM
Links:
Dr. John Cush RheumNow ( View Tweet)