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After failing a JAK inhibitor, can you still hit a JAK-pot?
Januse kinase (JAK) inhibitors are targeted synthetic disease modifying anti-rheumatic drugs (tsDMARDs) that have risen in popularity as earlier treatment options for rheumatoid arthritis.
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ACR21 Best Abstracts - Day 2
The RheumNow faculty reporters have been scouring and reporting on the best abstracts from the ACR. Here is a sampling of their choice abstract presentations reported during ACR 2020 Day 2 (#ACRbest).
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Baricitinib for *relapsing* GCA (Th1+Th17)
w abbreviated steroid wean (15-22w)
Despite being tougher to treat:
100% off steroids at 24w
93% off steroids at 52w
no ischemic Sx
promising as another GCA Rx option!
(post-cessation 4pts flared)
@MayoClinic #ACR21 ABST1396 @RheumNow https://t.co/dqFnHQYogk
David Liew drdavidliew ( View Tweet)
It is #ACR21, but it is also #COP26Glasgow 🌎! What can we do for climate as physicians? "Our job is to make changes" Strong message for #ClimateAction from Dr Paul Dellaripa during his talk at the climate, pollution and IRMDs study group session @RheumNow https://t.co/GWxpzYD3lg
Aurelie Najm AurelieRheumo ( View Tweet)
"GCA is not a single, monolithic disease"
- Christian Dejaco, rightfully asking why we don't stratify treatment/trials in GCA
#ACR21 PMR/GCA Study Group @RheumNow @Sarah_L_Mackie @profbdasgupta @EBRheum @RichardPAConway @SattuiSEMD @drceowen
David Liew drdavidliew ( View Tweet)
RheumNow’s expanded coverage of the #ACR21 Annual meeting is sponsored in part by @bmsnews, @JanssenUS, @Novartis. All content chosen by RheumNow and its Faculty.
Dr. John Cush RheumNow ( View Tweet)
#ACR21 Abs#0819. RheumTAP real-world cohort of pts tapering Rx in remission on RA
▶️ Pts tapering 7.6x ⬆️ likely to flare in f/u
Great convo soon on @Rheumnow re: tapering studies. @davidliew asks how many more times do we need to see drug w/d fail?
https://t.co/BiZSM7yp7o https://t.co/iDXGVpFZzB
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Rheum Pearls and Secrets
Not all (or most) ulcers is Behcet's! Here's a great approach to use in clinic. Jason Kolfenbach: "Sometimes, taking off the mask is worth it"
@Rheumnow https://t.co/OEBgf1eFhd
Eric Dein ericdeinmd ( View Tweet)
#ACR21. Powerful patient perspective by Amy Barron, RN and rheumatic patient
⭐️"I found hope advocating for arthritis" and found meaning in advocacy.
▶️ Consider talking to your patients about getting involved in ACR Advocacy to give purpose & community.
@ACRheumDC @CreakyJoints https://t.co/2mJRaShZQQ
Eric Dein ericdeinmd ( View Tweet)
Females axSpA pts presented w/ higher disease burden (fatigue/tiredness, & spinal pain at night.) Female axSpA pts achieved sign/symptom improvement with IXE later than male axSpA pts. Abs 0934 #ACR21 #RheumNow@RheumNow https://t.co/EGXnfeF6KQ https://t.co/TDF5zxtca7
Dr. Rachel Tate uptoTate ( View Tweet)
Oral Calcitonin not recommended for OA - studies did not show efficacy
Strontium Ranelate study below was considered a positive study in KOA with efficacy but had Cardiovascular toxicity - now off the market. https://t.co/gcYH9xoxeo
Bella Mehta bella_mehta ( View Tweet)
Wnt signaling - Lorecivivint is now in phase 3 https://t.co/JSk2nPBTrI
Bella Mehta bella_mehta ( View Tweet)
Abst 0789
Baker & colleagues examined adipokine levels in association with disease activity in RA patients
- Patients with high levels of adipokines less likely to achieve low disease activity & remission
- These patients more likely to escalate to b/tsDMARDs
#ACR21 @RheumNow https://t.co/1xlO4W9q9v
Akhil Sood MD AkhilSoodMD ( View Tweet)
Another exciting day at #ACR21 and covering for @RheumNow
Also presented my poster (Abstr 0587) DMARD Use in Medicare Patients with #RheumatoidArthritis and Risk of Long-Term Opioid Use
- DMARD users showed lower odds of long term opioid use compared to non-DMARD users https://t.co/2XZgYY8ORg
Akhil Sood MD AkhilSoodMD ( View Tweet)
Great time recapping D2 of ACR live with my fellow RheumNow Faculty! @RheumNow @drdavidliew @doctorRBC @DrMiniDey @swethaann23
Check it out here: https://t.co/4IcjkIlEb6
Be sure to keep tuning into https://t.co/nVnVgigOKL for more captivating coverage of #ACR21! https://t.co/Je6GxoBgiy
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
As old saying but updated goes: Wise man/woman/prefer not to answer says IF you STOP drugs they usually STOP working. True with TNFi in most diseases (RA, axSpA, etc). Also tue with #plaquenil in large #SLE study #ACR21 abst#0959 https://t.co/O6Ejg5sjjK
Janet Pope Janetbirdope ( View Tweet)
Recaps on highlights! This was fun!🤓
#ICYMI #ACR21 @RheumNow https://t.co/e7EjaDAzQ7
sheila RHEUMarampa ( View Tweet)
@RheumNow From Abst#3053 noted above, here we see the trend of urinary ALCAM with UPCr and renal-SLEDAI https://t.co/3Ujo8WTslO
Pedro Castillo _Castillo_Pedro ( View Tweet)
Stopping/reducing hydroxychloroquine (HCQ) in SLE associated with increased flares, especially for those in low disease activity or in remission. Super helpful data to share with pts wanting to reduce/dc HCQ.
#ACR21 Abst#0959 Plenary Session II @RheumNow https://t.co/i7jPDN2sgZ
Pedro Castillo _Castillo_Pedro ( View Tweet)
Dr FCardwell et al on Health Info use in SLE pts b4 and during COVID19 using an online survey
🦋#lupus specialists & fam physicians - ⬆preferred & trusted health info sources but access to them ⬇frequent during covid19
A call to action?📢
@RheumNow #ACR21 abs0880 @rheumarhyme https://t.co/1NBEAlFvHx
sheila RHEUMarampa ( View Tweet)
