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Triple DMARD Therapy Bested by Biologics in Swedish Registry

d Jack Cush, MD

The Swedish Register compared outcomes of 1502 rheumatoid arthritis (RA) patients initiating either biologics plus methotrexate (MTX) or triple therapy (MTX plus sulfasalazine plus hydroxychloroquine/chloroquine) and showed similar rates of sustained remission.

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CV Risk Decreased with Certain DMARDs in Rheumatoid Arthritis

d Jack Cush, MD

A large prospective cohort study examined the comparative risks of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) and found that, methotrexate (MTX), abatacept (ABA) and TNF inhibitor (TNFi) use were associated with a decreased risk of CV events. 

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Tocilizumab Augmented Efficacy in COVID-19 Pneumonia with High CRP

d Jack Cush, MD

JAMA Internal Medicine report an analysis of recent and composite trial data suggesting that tocilizumab (TCZ) therapy in COVID-19–associated pneumonia patients with high CRP levels is likely to be effective.

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Congress Slams AbbVie Over Price Hikes, 'Frivolous' Patents

d MedPage Today

House lawmakers on both sides of the aisle pummeled AbbVie CEO Richard Gonzalez for raising the price of two widely used drugs and for the company's "legally questionable" tactics to head off competition from biosimilars, despite pulling in healthy profits.

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Factors Associated with COVID-19 Deaths in Rheumatic Patients

d Jack Cush, MD

Analysis of data from the COVID-19 Global Rheumatology Alliance shows that rheumatic diseases infected with COVID-19 had a greater risk of death with age, comorbidities, high disease activity and few specific therapies.

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Dr. Samir V. Parikh from the #SLEEducatorsNetwork discusses the major treatment goals for lupus nephritis and the broader needs of the patient in this program- Defining Treatment Goals for Lupus Nephritis. Sponsored by GSK US Medical Affairs https://t.co/f2Y707YDJr https://t.co/lsYDVFWSCS

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Good Free 2 part series on Juvenile Fibromyalgia: a chronic diffuse musculoskeletal aching and pain syndrome that may be hard to distinguish from complex regional pain syndrome (CRPS) (ALWAYS CHECK FOR HYPERMOBILITY in Kids) https://t.co/EPmmGVNW63 https://t.co/aP6QHT7tiM

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Preliminary results from 600 pt SAVE-MORE trial in severe COVID, anakinra + standard-of-care was 55% better than SOC in preventing death or respiratory failure; and improving Hosp Discharge by 4 days. Anakinra Rx 100mg/day up to 10 days https://t.co/vbpUMQjC1o

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Popular Read: Little Effect with Multimodal Treatment of CMC1 Osteoarthritis https://t.co/6SnJYOK6nu https://t.co/ldTQRujshq

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RNL 2021 - Future Therapies in RA: Dr. Roy Fleischmann https://t.co/icnRaUHo5k

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Meet the #SLEEducatorsNetwork in this disease education series where leading rheumatologists and nephrologists share their perspectives on lupus nephritis. Sponsored by GSK US Medical Affairs https://t.co/H9BqP9bW4i https://t.co/VzS95UBJeo

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News: Factors Associated with COVID-19 Deaths in Rheumatic Patients https://t.co/FzsINtpZEz https://t.co/QzuLZRKaZy

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Levamisole, an anti-helminthic vet drug, is used as a colorless, odorless, adulterant to narcotics, cocaine, fentanyl, etc. Levamisole also causes ANCA+ Vasculitis (small to medium vessels), palpable purpura, agranulocytosis https://t.co/BKoDo2iemJ https://t.co/bSl0eYn0yO

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RheumNow Live is now available for all--check out any panels you may have missed. https://t.co/jaisVc2kGt https://t.co/Z9m7V96g1g

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Listen to Dr. Jack Cush review the news and journal reports from the past week on RheumNow. Our latest podcast is available for download on SoundCloud, Apple and Android carplay. https://t.co/FvmmOBAjC1 https://t.co/rrZO6jOlKt

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Italian study of 1216 rheumatic pts on DMARDs, Biologics underwent HBV testing. They found HBV in 15.7% (chronic infection: 0.4%, resolved infection: 12.6%, anti-HBc positivity alone: 2.6%). HBV reactivation occurred in 6.2%. Only 1 acute hepatitis https://t.co/WofN4rqq6p

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#RNL2021: Difficult, Refractory RA Dr. Maya Buch presents Difficult, Refractory RA at RheumNow Live 2021. https://t.co/YG8gBFVCod

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Sign up this week's Tuesday Night Rheumatology on RA and Vaccinations. We'll be starting at 7pm ET. Register: https://t.co/cmeOqacCXw https://t.co/prr7luBQgF

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Ischemic Forearm Test- used to Dx muscle weakness from McArdles dz (myophosphorylase defic). Pts nondominant arm exercised w/ BP cuff >20 mm above systolic BP), to exhaustion. Dx w/ increased ammonia but not lactate levels. https://t.co/LrY6PYZ1z3

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Severity Associated with Erosive Hand Osteoarthritis EHOA was studied as part of the Osteoarthritis Initiative, and shown to increase with advanced age and female sex, with developmental findings to suggest that EHOA as a disorder of skeletal frailty. https://t.co/3s8E4F6QDR https://t.co/xiDb0LGhCv

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