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Drug Choices After First TNF Inhibitor in RA
TNFi are frequently used first line in RA patients; and a new analysis shows that repeat use of TNFi dominates over the use of non-TNFi biologics when the initial TNFi therapy has failed. This retrospective analysis of commercial insurance records analyzed the patterns of drug use in adult RA patients who switched to their second biologic or targeted disease-modifying antirheumatic drug.
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JCI paper showing IgG fibromyalgia pts given to mice leads to passive transfer of FM symptoms leads to sensory hypersensitivity; increased sensitivity to noxious mechanical & cold stimulation, & nociceptive fibers in skin-nerve preparations.WHAT? https://t.co/af24a9BzzW
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Dr. John Cush RheumNow ( View Tweet)
New podcast available--Dr. Jack Cush reviews the news, journal reports and cautions regarding COVID-19.
https://t.co/rugwkPb8KQ https://t.co/dCCzlemjfu
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Dr. John Cush RheumNow ( View Tweet)
We've got another resource available on Cytokine Storm Management. Log in and download today.
https://t.co/dTAzMVa6SB https://t.co/BvsZFxGrQl
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The current NEJM reports that the use of the Pfizer mRNA vaccine (BNT162b2) demonstrated a very low risk for certain serious adverse events, including the risk of myocarditis (1 to 5 events per 100,000 persons).
https://t.co/CT4dQK9XlH https://t.co/enddiHtX1G
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1458 RA patients (74% seropositive) followed longitudinally for ROM & surgical outcomes. Seropositive and seronegative patients had loss of ROM over time (7–13%/Yr), and surgical needs. T2T approaches should be followed irrespective of RF status https://t.co/ohmDTLfP9S
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Dr. John Cush RheumNow ( View Tweet)
85% relapse median 22 wks , 20% ISR, quickly regain MDA, why would you? https://t.co/VtQ3ClumBl
Peter Nash drpnash ( View Tweet)
Can an anti-inflammatory diet impact axial spondyloarthritis (axSpA)? A 6-month dietary intervention shows that adherence to a Mediterranean diet lowers disease activity in axSpA; but dietary adherence is often incomplete.
https://t.co/AqtYO60XbH https://t.co/uYil2YvOR1
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Dr. John Cush RheumNow ( View Tweet)
A current report in Arthritis & Rheumatology examined the Nurses Health Study II data set and shows that parental smoking, and passive exposure to children, can later lead to an increased risk of adult-onset incident seropositive RA.
https://t.co/szl5L7DGJG https://t.co/vAXBNPxsWU
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Dr. John Cush RheumNow ( View Tweet)
Arthritis clinic referrals divided into 2 cohorts: (A) 163 w/ MSK US before visit; (B) 109 without initial MSK US. MSK-US at 1st visit reduced time to Dx from mean 31 to 12 days (p< 0.01), # of clinic visits, & increased odds of inflamm Dx (47% vs 27%) https://t.co/FaXLBlRlxy
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Dr. John Cush RheumNow ( View Tweet)
Rheumatic Events With Checkpoint Inhibitors: Tumor Type Matters
https://t.co/vT6185ycoG https://t.co/G14eLN2JkT
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Dr. John Cush RheumNow ( View Tweet)
Si @DGlaucomflecken es el mejor se dice y ya está https://t.co/QzPyIe5gAA
Raruniente Raruniiente ( View Tweet)
New podcast available for download!
COVID Marching Amidst the Madness
https://t.co/xYzkw3zGRt https://t.co/gv45nVk9v5
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In case you missed it:
Biologic Therapy of Psoriasis May Prevent Psoriatic Arthritis
Another retrospective cohort study has shown that biologic treatment of psoriasis may reduce the subsequent incidence of psoriatic arthritis (PsA).
https://t.co/2YbLBsFedv https://t.co/OYMJ6Y54UF
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Dr. John Cush RheumNow ( View Tweet)
ICYMI:
European Commission approves upadacitinib (Rinvoq)-first JAK Inhibitor for use in adults & adolescents with Moderate to Severe Atopic Dermatitis. UPA is approved for atopic dermatitis in other nations, Russia, Saudi Arabia; pending review in US https://t.co/hiPkJoJCex
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ICYMI:
European Commission has approved tofacitinib (Xeljanz) to treat active polyarticular juvenile idiopathic arthritis & juvenile psoriatic arthritis (PsA) > 2yrs old, not responding to DMARDs (as tablet & new oral solution (weight-based dosing) https://t.co/FyqZI0qsYa
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Oligoarticular vs. Polyarticular Psoriatic Arthritis
https://t.co/lQVNdmWgMc https://t.co/ZjyDeYTLe2
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Dr. John Cush RheumNow ( View Tweet)
We've got a new podcast up for you, focusing on all of this week's top stories on RheumNow.
https://t.co/xYzkw3zGRt https://t.co/A75Cl3WYno
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Dr. John Cush RheumNow ( View Tweet)
Cochrane review finds only 2 studies showing tocilizumab to be beneficial in GCA (sustained remission, relapse-free survival, need for escape therapy). https://t.co/sQjIBAiWKN
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Dr. John Cush RheumNow ( View Tweet)
Swedish study of 287 SLE pts shows rare risk of autoimmune liver disease. While 14% had persistent LFTs, only 2.8% dx w/ autoimmune hepatitis. 1.4-2.1% met criteria for primary biliary cholangitis. Both AIH & PBC AIH are overrepresented in SLE https://t.co/oc5SLJtycf
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Dr. John Cush RheumNow ( View Tweet)
