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Reader beware: Interpretation of relative effectiveness & safety of JAKi vs bDMARDs in real world data
POS0093 JAK-pot
heterogeneity between countries with variable safety @RheumNow @eular_org #EULAR2021
19 registries >700 JAK RA Rx markedly diff d/c due to AEs https://t.co/jFgN8NVx8v
Janet Pope Janetbirdope ( View Tweet)
Comparative effectiveness in RWD of retention of #tofacitinib vs #bDMARDs Equal d/c of Tofa and TNFI in RA in OBRI and Rhumatdata, Canadian databases
OP0179 #EULAR2021 @RheumNow @eular_org
1/3 in each group d/c Rx. Some other studies show retention better on JAKi than bDMARDs.
Janet Pope Janetbirdope ( View Tweet)
Real world data comparing #TNFi to nonTNFi Effectiveness in US RISE registry >16000 pts OP0117 No diff in DAS in RA between TNFi and non TNFi use
Diff ethnicities may make a difference & SES factors. So interpretation of diff registries may show diff results @RheumNow @eular_org
Janet Pope Janetbirdope ( View Tweet)
More zoster but ⬆️serious infections also in >3700 RA pts from BIOBASDER comparing #JAKi to #bDMARD. ? Due to later line Rx w JAKi? This is diff from some registries/ real world data wher other than HZ, serious infections are equal. OP0123 @RheumNow @eular_org
Janet Pope Janetbirdope ( View Tweet)
Smog makes arthritis flare! Study of air pollution & flares in 888 RA pts. With higher air pollution, 70% ⬆️risk of ⬆️CRP. Pts Nitric oxide exposed cumulative over 60 days had higher DAS but <5% of drug changes explained by air pollution. OP0178 @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
Comorbidities in RA ⬇️response at 6 months with first bDMARD! 501 pts with 1098 bDMARDs Rx. Presence of baseline comorbidities predicted poor response & worse if ⬆️comorbidities. OP0299 @eular_org @RheumNow #EULAR2021 https://t.co/P9pYf93NXw
Janet Pope Janetbirdope ( View Tweet)
Make sure #SLE pts with > 5 yrs of #Plaquenil get their regular FULL retinal screening. Retinal toxicity 6.8% for HCQ>5 years. risks seem to be cumulative dose, higher daily dose in users >5 yrs OP0133 @eular_org @RheumNow #EULAR2021 https://t.co/mVCdMxA2LX
Janet Pope Janetbirdope ( View Tweet)
Does she or doesn’t she have swollen jts during telemed call? Referred pts with suspected IA marked swollen jts on a mannequin. In 1637 pts 3/4 marked 1 or more jts ~41% had SJC by Rheum exam. Sens 87% but spec only 31%. Reasonable screen. POS1418 @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
What costs more in #SLE? Hospitalization for lupus nephritis or for mental health? @RheumNow @eular_org #EULAR2021 POS0304
Janet Pope Janetbirdope ( View Tweet)
Can I use #Rituximab during #pandemic? Ritux blunts response to #SARSCoV2 #vaccine LB0003 & worse outcomes vs other Rheum meds (also pred) from Global Rheum Alliance OP0006 but pts on Rituximab have worse disease ~ANCA vasculitis& diff to Rx RA. @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
Pts will achieve LESS remission in RA, PsA & SpA if high pain catastrophizing score ~50% less remission in RA, even less in PsA (but not stat signif in PsA) ~75% less in axSpA. OP0089 @RheumNow @eular_org #EULAR2021
Janet Pope Janetbirdope ( View Tweet)
Rx of lupus nephritis in 2022 should have LESS prednisone, MMF + one of #voclosporin or #belimumab or #obinutizumab or #tacrolimus etc. Combine #MMF with another immunesuppressant for better outcomes #EULAR2021 @RheumNow @eular_org Voclosporin sustained benefit at 2 yrs POS0681
Janet Pope Janetbirdope ( View Tweet)
tyk2 makes sense to inhibit in PsA. Part of kinase family including JAK/TYK2, TYK2 is ⬆️in PsA. Deficiency of TYK2 gives less autoimmune diseases. @RheumNow @eular_org #EULAR2021 BMS Tyk Talk symposium https://t.co/knP9n0Qc0u
Janet Pope Janetbirdope ( View Tweet)
@KDAO2011 animal support is crucial to #EULAR2021 learning! https://t.co/Y1OalGcU6c
Robert B Chao, MD doctorRBC ( View Tweet)
@ARD_BMJ @alessia_alunno Retrospective picture from Friday evening replacing and in honour of the #EULAR2021 congress dinner. https://t.co/jzPp1s2SZD
Paul Studenic Stiddyo ( View Tweet)
Our Final poll results from #EULAR2021 are out. Landslide victory for #ANA to not be routinely monitored in patients treated with #TNF inhibitors or only checked when features of SLE are present @RheumNow https://t.co/4AGxHGPkco
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
?Counter intuitive to have ⬇️autoimmune conditions in Sero+ RA vs seronegative but could be due to other genes that are more common in seronegative ex TNF promoter gene, PTPN22 CARD15, STAT4 etc that cluster with IBD, DMType1 etc & not shared epitope POS0313 #EULAR2021 @RheumNow https://t.co/eqLCTIU7A7
Janet Pope Janetbirdope ( View Tweet)
You get more general autoimmune disease in seropos RA, right?
Not compared to seroneg RA, as it so happens (incidence and point prevalence).
If anything, it leans the other way - what number of things is seroneg RA, anyway?
DANBIO data POS0313 #EULAR2021 @RheumNow https://t.co/mKJQ2jjCU4
David Liew drdavidliew ( View Tweet)
Video: Psoriatic Arthritis Highlights from #EULAR2021 Dr. Jack Cush
https://t.co/xedmiZKOd5 https://t.co/AShEze5rFy
Links:
Dr. John Cush RheumNow ( View Tweet)
Find our #EULAR2021 psoriatic arthritis coverage in one place.
https://t.co/NzB2e2Vfwb https://t.co/P8TfUxfA3F
Links:
Dr. John Cush RheumNow ( View Tweet)
