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The case for starting combo Rx for LN (rather than sequential Rx):
👉Aurora trial: voclosporin + MMF (vs. MMF only) prompt efficacy on proteinuria across all ethnic subgroups, twice more complete renal response , no major safety signals. slide 1/ #EULAR2021 @rheumnow https://t.co/TA5i9ITuL7
k dao KDAO2011 ( View Tweet)
#Digital #rheumatology in the era of #COVID-19: evidently increasing inclination of patients and physicians to use digital health apps for recording data- as informed by a national survey by @JK77775 and colleagues #EULAR2021 @ARD_BMJ https://t.co/Uo60qZurhG
Latika LatikaGupta_ ( View Tweet)
So it comes down to the grand question: how on earth do we actually monitor disease activity??
"We still don't have a failsafe algorithm... relapse is both underdiagnosed & overdiagnosed" - @Sarah_L_Mackie
The challenge lots of good people are working on!
#EULAR2021 @RheumNow https://t.co/PUa6Ly1DQw
David Liew drdavidliew ( View Tweet)
OP0131: Pooled data from TULIP-1 and TULIP-2 show anifrolumab (anti-IFN receptor Ab) show improvement of rash and arthritis. Shows promise for drug, particularly in subset of pts with high IFN activity #EULAR2021 @RheumNow https://t.co/sddF2NRlEg
Eric Dein ejdein1 ( View Tweet)
MUC5B promoter variant is associated with interstitial lung disease.
Interactions with:
👉rheumatoid arthritis
👉 age
👉 sex
Check this Finnish biobank study of 250,000 individuals presented by Antti Palömaki at the Plenary Abstracts Session Wed 02/06 16:15
>LC
ARD & RMD Open ARD_BMJ ( View Tweet)
Patients selected to maximise response & minimise adverse events in RA & PsA trials.
What implications does this have when we interpret the data & try to apply in clinic?
#EULAR2021 https://t.co/CocKlvjme4
Dr Irwin Lim _connectedcare ( View Tweet)
Placebo response in PsA trials have more than doubled in last decade.
Due to patient characteristics, patient expectations?
Makes it very difficult to compare between trials
#EULAR2021 https://t.co/XQk4hqrYN8
Dr Irwin Lim _connectedcare ( View Tweet)
Drug-induced ANCA-associated vasculitis:
here are the ones to look for👇
- hydralazine
- PTU
- penicillamine
- thiamazole
- sofosbuvir
- minocycline
- carbimazole
(but then a few others floating about!)
VigiBase data POS0118 #EULAR2021 @RheumNow https://t.co/ujgJAJQeKY
David Liew drdavidliew ( View Tweet)
Worse dentition is associated with worse RA disease activity.
And that's the tooth!🙄
from two big German cohorts @CallhoffJ POS0026 #EULAR2021 @RheumNow https://t.co/rjCQ6AtQzq
David Liew drdavidliew ( View Tweet)
COAST-V: IXE ⬇️SP-N & spinal pain in r-axSpA pts w/ or w/o ⬆️ CRP or morning stiffness. Pts treated w/ ADA re-randomized to IXE showed further⬇️in SP-N & spinal pain. Poster #POS0901 #EULAR2021 @RheumNow https://t.co/46qiqrohbX https://t.co/uB15oTwztV
Dr. Rachel Tate uptoTate ( View Tweet)
"But, effectively communicating overdiagnosis is a challenge in light of entrenched beliefs about the benefits of testing and the culture of current journalism practices." @raymoynihan et al in @BMJ_Open. https://t.co/1DW5OIMh6R
Ivan Oransky ivanoransky ( View Tweet)
ERA & JPsA children & adolescents tx'ed w/ SEC, JUNIPERA 104wk data: longer time to flare vs PBO. NRI analysis: 87.2%, 83.7%, 67.4%, 38.4% and 24.4% achieved JIA ACR 30/50/70/90/100, respectively. No new safety signals. #EULAR2021 @RheumNow Abstract #LB004 https://t.co/reWawBWfqh https://t.co/9gzKKU1xrm
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
Fascinating talk by Dr Tombetti on the potential use of arterial wall derived microvesicles collected from plasma as a means of non-invasive liquid biopsy in vasculitis @RheumNow #EULAR2021 Abstr#OP0056 https://t.co/Y6UO2mpjV0
Richard Conway RichardPAConway ( View Tweet)
After this morning's great discussion at the #epidemiology interest group, Prof Nagy gives a summary of the @eular_org Definition of difficult-to-treat #RheumatoidArthritis at #EULAR2021, including a great summary of the elements and evidence behind the recommendation. https://t.co/imXECTlUbf
EMEUNET EMEUNET ( View Tweet)
Additional results from @rheum_covid trainee survey re: Telemedicine presented in AB0674:
📱dramatic ⬆️ in telemed (13% to 83%) during pandemic
📱limited training and supervision
📱trainees felt telemed negatively impacted supervision & clin teaching quality
#EULAR2021 https://t.co/44X5UprD7V
Kristen Young kristenyoung ( View Tweet)
Bariatric surgery decreases the risk of moderate-to-severe hip or knee osteoarthritis.
Burkard. OP0106
#EULAR2021 > FB https://t.co/qh1RQfcvM2
ARD & RMD Open ARD_BMJ ( View Tweet)
Presented results from @rheum_covid Trainee Survey today at #EULAR21 (POS0051):
👎🏼 trainees felt multiple domains in clinical care & research were negatively impacted by pandemic
🔥 50% felt burntout with 68% with ⬆️ of work related stress
🗣@SuAnnYeoh1, @rheumed & team https://t.co/KXei6r6ZHn
Kristen Young kristenyoung ( View Tweet)
Following this morning's excellent group discussion on #D2T #RA, Prof Nagy presents @eular_org Definition of #difficulttotreat RA at #EULAR2021
D2T disease, consider:
👉🏼Treatment history
👉🏼Presence of one of the below factors
👉🏼Mx of difficult signs/symptoms as per clinician https://t.co/xbtKuvjLw4
Mrinalini Dey DrMiniDey ( View Tweet)
Moysidou et al reviewed pubmed registries/longitudinal cohort studies in PsA. 27 registries, totaling 30 countries (67% European, 26% N. American) Africa not represented. This is a call to arms for global PsA pts! #EULAR2021 @RheumNow Poster #POS1078 https://t.co/rsQYR6NFNT https://t.co/MU3FVXuRxS
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
Dr Lam presenting data on early RA and matched controls. T2T strategy led to no increased CV event risk over 5 years. Longer remission duration protective, higher baseline HAQ associated with higher risk @RheumNow #EULAR2021 Abstr#OP0103 https://t.co/MZdEoyWI64
Richard Conway RichardPAConway ( View Tweet)
