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Best Interventions for Gout Flares

d Jack Cush, MD

A recent metanalysis assessed the comparative efficacy of current first-line pharmacologic antiinflammatory interventions for gout flares and surmised that canakinumab and intravenous or intramuscular corticosteroids are superior to  nonsteroidal antiinflammatory drugs [NSAIDs].

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pill,ASA,colchcine,small

COLCORONA: Protective Effect of Colchicine in COVID-19

d Jack Cush, MD

Lancet Respiratory Medicine has reported the results of the COLCORONA trial, showing that in patients with PCR-confirmed COVID-19 infection, colchicine led to a significantly lower rate of death or hospital admission from COVID.

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Top May Tweet: Belimumab now approved in the EU for lupus nephritis. The EMA has approved intravenous and subcutaneous Benlysta (belimumab) in combination with background immunosuppressive therapies for adults with active lupus nephritis https://t.co/Twbe1ClT5w

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Hands-Down Rheumatology - Mechanics hands - rough, thickened/caloused, cracks/fissures; seen in 20-70% of dermatomyositis; associated with the anti-synthetase syndrome, but also w/ lung dz and amyopathic DM https://t.co/bkCI3SUXNh https://t.co/jrOGkKAm9z

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Hands-Down Rheumatology - Swollen Hands In Rheumatoid Arthritis - could be from synovitis, tenosynovitis, edema, effusion, bony hypertrophy, nodules, secondary OA. https://t.co/dRCMzgdHqf

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Hands-Down Rheumatology - Erosive hand osteoarthritis (EHOA) affects 2.6% of knee OA pts (from Osteoarthritis Initiative) Risk factors - older [RR 0.76), female (RR=1.73), greater OA severity, and "thinner bones" https://t.co/3s8E4F6QDR

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News: Triple DMARD Therapy Bested by Biologics in Swedish Registry The Swedish Register compared outcomes of 1502 RA patients initiating either biologics plus MTX or triple therapy and showed similar rates of sustained remission. https://t.co/7JJxGF1tHz https://t.co/ht6kAsJkb9

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RheumNow Podcast – Heart, Lung & Liver (5.28.2021) Dr Jack Cush reviews the news and journal reports from this past week on RheumNow. https://t.co/a9fvgaJVnQ https://t.co/r3nbf2Ftdb

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News: EULAR Guidelines on Intraarticular Therapy EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. https://t.co/Z6vC0x9zY1 https://t.co/gVCWMIJxtu

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Study of National inpatient sample database (2015 to 2017) showed the frequency of atrial fibrillation in rheumatic disease (RD) pts finding that AF frequency highest in gout followed by vasculitis, and PMR. RD Mortality was 2 fold higher with AF. https://t.co/enno6hrKOI

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A trial of sarilumab in 431 hospitalized COVID-19 patients on supplemental oxygen, Compared to placebo, sarilumab did not improve COVID outcomes https://t.co/postv1eK3F

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Kidney biopsies in patients with lupus – how early and how often? Dr. Fogo and Dr.Hogan explain why a kidney biopsy is critical for diagnosis and characterization of kidney involvement by SLE #SLEEducatorsNetwork. Sponsored by GSK US Medical Affairs https://t.co/ta3hliB9ls https://t.co/hJE6BNlNqk

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Pirfenidone, studied in 127 pts w/ CVD/CTD ILD, fibrotic interstitial pneumonia, chr hypersensitivity pneumonitis, & asbestoslung fibrosis. Pirefenidone had significantly less FVC% decline compared with placebo (p=0·043) https://t.co/H1s6ut4NhG

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Dr. Samir V. Parikh from the #SLEEducatorsNetwork discusses the major treatment goals for lupus nephritis and the broader needs of the patient in this program- Defining Treatment Goals for Lupus Nephritis. Sponsored by GSK US Medical Affairs https://t.co/f2Y707H2kR https://t.co/4xMIBp2yEh

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RNL 2021: Treatment Advances in SpA: Dr. Nigil Haroon Dr. Nigil Haroon presents Treatment Advances in SpA at RheumNow Live 2021. https://t.co/9ZA0loThx6

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News: Methotrexate Impairs COVID Vax Response https://t.co/M9d31UAxb7

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New podcast up! Download wherever podcasts are available. https://t.co/y95zS04pqw

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News: Efficacy of 6 Weeks Antibiotics with Prosthetic Joint Infections https://t.co/mSDEIKUL1h

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Danish registry study of 1,356 psoriasis and 370 PsA pts shows increased odd of coronary disease by CT Calcium scores - psoriasis w CACS ≥ 400 OR 1.25 (1.04-1.50); PsA CACS>0 OR 1.28 (1.00-1.64). Nearly a 49% incr risk in PSO (HR 1.49) https://t.co/jQSAV66TAi

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Cross-sectional study RA and PFTs, shows among 2,008 cases, RA was assoc w/ increased odds of restrictive (OR 1.36) & obstructive patterns (OR 1.21) not explained by confounders like smoking. RA had lower predicted FEV1, FVC, FEV1/FVC https://t.co/cVxatLQCG4

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