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Janet Pope Tweet
Janetbirdope
#Top #EULAR learnings #SLE #recommendations 1 Limit #prednisone 2 use #biologics early if poor prognosis 3 #lupus #nephritis - treat early with #belimumab or #voclosporin and more Rx in #RCTs #gamechanger https://t.co/JHQHu91tud
David Liew Tweet
drdavidliew
Wasn’t following the SLE stuff #EULAR2023 but heard a lot of talk about both telitacicept & CAR-T, including meeting highlights by Christian Dejaco. Both look pretty exciting - the longer the sustained remission with CAR-T, the more it looks like maybe the real deal @RheumNow https://t.co/oKzb8ojTcz
Md Yuzaiful Md Yusof Tweet
Yuz6Yusof
#EULAR2023 #POS1156 Previous case series reported ~9% de novo nephritis in #SLE pts treated with belimumab for non-renal lupus. Post-hoc analysis of 5 BEL Non-LN RCTs showed 8% had de novo LN. Risk increased in Asians but lowered with low dose BEL or s/c form @RheumNow https://t.co/GqAr3tppWh
David Liew Tweet
drdavidliew
New 2023 @eular_org SLE recommendations Key changes, in response to evidence: - more caution re: steroids - biologics earlier - combo therapy (BEL or CNI/VCS) considered for lupus nephritis #EULAR2023 @RheumNow https://t.co/J3Lp8owRyT
Janet Pope Tweet
Janetbirdope
#ClinicalPearl This is cool - think of SGLT2 for #lupus #nephritis? presented at #SLE recommendations ⁦@RheumNow⁩ #EULAR2023 ⁦@eular_org⁩ https://t.co/8mbNt2n64v
Janet Pope Tweet
Janetbirdope
#SLE #EULAR recommendations What is new - use LESS #glucocorticoids, aim for none or 5 mg/d or less, use #biologics early if needed to prevent damage, #lupus #nephritis consider less pulse dose if using, voclosporin vs Belimumab ? it depends @RheumNow #EULAR2023 https://t.co/Ylnnl3pHOK
Bella Mehta Tweet
bella_mehta
Diagnostic delay in #lupus is really prevalent! #EULAR2023 @RheumNow 20% with new lupus diagnosis are hospitalized! 20% diagnosis is delayed for more than 3 months! https://t.co/1vCcezBrQS
Bella Mehta Tweet
bella_mehta
Meds in #lupus at #EULAR2023 recs - HCQ first line therapy. Target dose remains the same. Some discussion on monitoring levels if possible - MAIN CHANGE - Glucocorticoids to be minimized (only use for bridging). Nephrologists more so in favor of steroid free remission @RheumNow https://t.co/d8WnUOgrwq
Bella Mehta Tweet
bella_mehta
CAR-T cells in refarctory SLE- long term data presented #EULAR2023 Pts did well except some mild cytopenias. Pts remained in remission. Maybe a good option in the near future for refractory pts! @RheumNow https://t.co/NWoFBipOiQ
Bella Mehta Tweet
bella_mehta
With the single cell RNA sequencing analysis being my more affordable (relatively) and widely used! Science is moving forward. Highlights in basic science and translational data #EULAR2023 @RheumNow https://t.co/sS7xLeNyLW
Md Yuzaiful Md Yusof Tweet
Yuz6Yusof
#EULAR2023 #LB0005 Can we improve trial design of Bcell depletion in #SLE? Feasibility RCT of RTX in organ specific MSK showed: a)feasible to use ultrasound & clinical as endpoints, b)new tool LAMDA is responsive, c)potential worsening before later improvement with RTX @RheumNow https://t.co/kGDZ6EqLtq
Md Yuzaiful Md Yusof Tweet
Yuz6Yusof
#EULAR2023 #OP0290 Heterogeneity in #SLE is not only disease features but think of ANCESTRY. Data from BILAG-BR registry showed worse outcomes in people of Black and South Asian treated with either Rituximab or Belimumab (adjusted for deprivation index) @RheumNow https://t.co/bcdu9RIFSx
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