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RheumNow Podcast - Despite Corona (3.6.20)

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d Jack Cush, MD

Mar 06, 2020

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

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Need for Disruptive Innovation in Rheumatology

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d Jack Cush, MD

Mar 05, 2020

A full-read, novel Viewpoint article published in the Annals of Rheumatic Disease (Huizinga TWJ, et al) spotlights a recent international meeting of big thinkers, scientific collaborators and industry dedicated to innovation in rheumatology.

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Venom Peptide-Steroid Conjugate Effective in Collagen Induced Arthritis

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d Jack Cush, MD

Mar 05, 2020

Science Translational Medicine features a report from the Fred Hutchinson Cancer Research Center showing that a scopion venom peptide, coupled to steroid, can significantly reduce joint inflammation in a rat model of rheumatoid arthritis (RA).

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Updates on Psoriatic Arthritis at ACR 2018

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d Dr. Philip Gardiner

Mar 05, 2020

I think 2018 was the year that belonged to psoriatic arthritis (although some may argue in favor of immune conditions induced by Checkpoint inhibitors). Many years ago the late Professor Verna Wright in Leeds (UK) was a lone voice for many years describing the clinical subtypes of Psoriatic arthritis as something distinctive from rheumatoid arthritis. For a long time we thought that the treatments for PsA were just the same as RA since we were treating the same problem of synovitis.

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Drug Interactions with Cannabinoids

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d Jack Cush, MD

Mar 04, 2020

Cannbinoids are widely available and used for a variety of indications, but little is known about their safety and their potential for drug interactions. The Canadian Medical Journal has published a review of drug interactions with cannabinoids, many of which are mediated by cytochrome-P450 metabolism.

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Check out the last 2 QD clinics on 7 DMARDs & counting and Kid Arthritis - on iTUNES or here >> https://t.co/4gDqvqHjnl and https://t.co/Lij5ot15gq

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Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2020

Breast cancer pts taking Aromatase Inhibitors have higher Risk of Arthritis (13% vs 8.2%, p < 0.0001) & carpal tunnel (1.4% vs 0.8%, p 0.008). Taiwanese Claims Analysis of 2,055 women w/ breast cancer taking tamoxifen, anastrozole, letrozole, exemestane. https://t.co/K7IzqjN28M

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Aromatase Inhibitors and Risk of Arthritis and Carpal Tunnel Syndrome among Tai…

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2020

Fasting during Ramadan, 9th mo of Islamic calendar, with intermittent fasting (sunrise to sunset) shown to reduce Dz activity (compare pre/post fasting); 36 RA DAS 28 CRP decreased 4.3 to 3.5 (p < 0.001); 20 SpA pts 3.4 to 2.9 1.3 (p = 0.001). https://t.co/SI7jgXWz7w

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Impact of Ramadan diurnal intermittent fasting on rheumatic diseases | Springer…

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2020

Small phase II pilot trial of Tocilizumab in JIA (n=22) associated uveitis failed to show efficacy - 34% (7/21) responded to treatment (p=0·11). https://t.co/2EoCfLcVOA

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DEFINE_ME

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2020

"A fanatic is one who can't change his mind and won't change the subject" -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2020

Risk factors for severe cranial ischaemic complications (sCIC) in GCA studied in 295 pts - 61 developed sCIC. Vision complications increased with age & jaw claudication (OR 3.43); decreased with PMR Sxs & higher CRP. Afib independent predictor of stroke. https://t.co/8VoZoVGVIp

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Risk factors for severe cranial ischaemic complications in giant cell arteritis…

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2020

Study of 244 PsA &198 AS pts finds B27(+) in 25% PsA, 75% in AS. HLA‐B27 more likely to be younger, male, longer Dz duration, higher Xray scores. B27 was signif assoc w/ syndesmophyte symmetry, marginal syndesmophytes, but not sacroiliac symmetry. https://t.co/8MFVrTLWmF

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http://bit.ly/3albfvv

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2020

ANA positivity very common with liver diseases - 91% in syst autoimmune dz, 93% in PBC, 49% Autoimmune hepatitis, 19% in HBV, 14% in HCV, 23.5% in Hepatocellular carcinoma; but few had ANA ≥ 1:320 (5 HCC, 2.5%HBV, 1.6% HCV). Patterns also varied. https://t.co/1wnr9sHjye

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Investigation and analysis of HEp 2 indirect immunofluorescence titers and patt…

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2020

Apheresis not generally rec for SLE but .... Could be useful w alveolar hemorrhage, etc. Dr Compton #Utsw Rheum Grand Rounds https://t.co/fIBAMWVU4W