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Fatigue Looms Large in Lupus

d RheumNow

Fatigue is an important component of the disease experience in systemic lupus erythematosus (SLE), and can have a profound impact on patients' perception of well-being, Italian researchers reported.

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Why You Should Come to RheumNow Live March 13th

d Jack Cush, MD

RheumNow Live kicks off its second annual meeting - a little, big meeting in Fort Worth - in just 2 weeks and I think you should be there.

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Bariatric Surgery Improves Rheumatoid Activity

d Jack Cush, MD

Obesity is a risk factor for the onset of rheumatoid arthritis (RA) and may also an impediment to optimal DMARD and biologic responses.  A new study has shown that after 1 year, obese RA patients undergoing bariatric surgery with weight loss had significantly lower disease activity.

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ACR Releases Reproductive Health Guidelines for Rheumatic Diseases

d Jack Cush, MD

Today, the American College of Rheumatology (ACR) published the 2020 Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases.

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Methotrexate and the Risk of Lung Disease

d Kathryn Dao, MD

Rheumatology has a comprehensive overview of methotrexate (MTX) and the risk of lung injury, MTX-related pneumonitis and interstitial lung disease (RA-ILD) with rheumatoid arthritis (RA).  Past reports suggest the frequence of MTX-pneumonitis to be between 0.3 and 11.6%; r

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Hyperuricemia Predisposes to Coronary Artery Disease in Men

d Jack Cush, MD

There are numerous associations between hyperuricemia and cardiovascular disease (CVD). An analysis of the Swedish SCAPIS Pilot study shows that higher levels of serum urate (SU) are associated with an increase in coronary artery calcification score in men but not in women. SU is not associated with common carotid intima-media thickness and carotid plaque scores in either men or women.

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Pregnancy Outcomes Improve in Lupus

d RheumNow

Pregnancy for patients with lupus has long been considered high risk and associated with both medical and obstetric complications, but outcomes have improved over the last 2 decades and continue to improve.

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Long term safety of Sarilumab reviewed. 2887 SAR pts on Combo and 471 on SAR mono Rx for up to 7.3 yrs (8188 PYs). SAEs 9.4 & 6.7/100PY; SIE 3.7 &, H zoster (0.5-0.6/100PY), GI perforations < 0.1/100PY & Cancer 0.7-.6. ANC <1000 in 13-15% https://t.co/YA2TKCdpGY

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Dr. John Cush RheumNow ( View Tweet)

Study of metformin in NON-diabetics w/ inflammatory disease on Pred >20/d shows metformin to to reduce pneumonia, serious infections, markers of carbohydrate/lipid,/liver & bone metabolism (vs PBO) but had no effect on truncal fat https://t.co/8RE2fJMkv9

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Dr. John Cush RheumNow ( View Tweet)

Prof Dinesh Khanna has an algorithm for SSc ILD. High CRP is a risk. HRCT is only low radiation so use for dx and prognosis #CRA2020 great lecture @RheumNow @earlyarthritis @sclerodermaUM https://t.co/VgltxqFKCo
Janet Pope Janetbirdope ( View Tweet)
Syphilis = The great imitator! Dx further muddled by periods of active and inactive disease. 2 main diagnostic algorithms that rely on serology, and both have pitfalls! @LCalabreseDO @NEJM @HealioRheum https://t.co/PvIG8hX0Ht https://t.co/EFTBYhK8QF

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Cassandra Calabrese CCalabreseDO ( View Tweet)
Anyone else getting hysterical patients? They want to stop their biologic because they “know” they are going to get #COVID2019 . I tell them their risk of their disease flaring off med is 100% while their risk for the infection is <1%. What do you tell your patients? @RheumNow https://t.co/2I8kVlKLOC

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k dao KDAO2011 ( View Tweet)

Hospital for Special Surgery (HSS) announced the appointment of S. Louis Bridges, Jr., MD, PhD, as the new Physician-in-Chief and Chair of the Division of Rheumatology, effective September 1, 2020. Dr. Bridges succeeds Mary K. Crow, MD https://t.co/TQ55jMOXHj

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Dr. John Cush RheumNow ( View Tweet)

HIP ATTACK trial assessed if accelerated surgery could reduce mortality & complications. 2970 Pts recv accelerated surgery (6 hr) vs standard care (24hrs). Risk of death (9-10%) & infection was the same; thus accelerated surgery did not lower risk https://t.co/Z4ld0RoRSX

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Dr. John Cush RheumNow ( View Tweet)

The use of cannabis in the past year by adults 65 years and older in the United States increased sharply from 0.4% in 2006 and 2007 to 2.9% in 2015 and 2016 https://t.co/RCVsKvGBI5

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Dr. John Cush RheumNow ( View Tweet)

"Difficulties mastered are opportunities won." - WInston Churchill

Dr. John Cush RheumNow ( View Tweet)

Brazil Biologics registry studied 1121 RA & 577 SpA pts and found serious infectious adverse events were more common with first TNFi (adjusted IR ratio, 2.96; p < 0.001) & still higher with 2nd TNFi (vs 1st TNFI) (adjusted IR ratio, 1.55) https://t.co/FpliYorsyG

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of homocysteine (HCY) levels in SLE; 36 articles compared 2919 SLE to 3120 controls. HCY levels were significantly higher in SLE vs healthy controls (P < 0.001), esp w/ age, Dz activity, Dz duration and BMI >23. HCY is important in SLE https://t.co/NVQ4KRJMR4

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Dr. John Cush RheumNow ( View Tweet)

FDA has approved IV meloxicam injection (called Anjeso, from Baudax Bio) for the treatment of moderate to severe pain in adults. Based on two phase 3 efficacy trials and one phase 3 safety study. https://t.co/5coeDacq7M

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Dr. John Cush RheumNow ( View Tweet)

"Play the game for more than you can afford to lose... only then will you learn the game." -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

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