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PEXIVAS - Plasma Exhange Fails to Boost Outcomes in Severe AAV
The PEXIVAS study showed that plasma exchange did not reduce the incidence of death or ESKD in patients with severe ANCA–associated vasculitis.
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Anaphylaxis or not. fever is NOT anaphylactic. IgE has flushing, itch and hives. Cytokine release has flushing and fever Dr A Postolova #RWCS2020 @RheumNow https://t.co/qgP1vP7Yfe
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Delayed hypersensitivity includes serum sickness usually at day 5 to 7. Anna Postolova says. #RWCS2020 @RheumNow https://t.co/sQFYIvDGLq
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If you skin test for IgE reaction don’t test in first 2 weeks post reaction as pt is Anergic then. Sweet spot is at 6 to 8 weeks to test and de sensitive if drug is needed and serious allergic reaction Dr A Postolova #RWCS2020 @RheumNow https://t.co/jakSwJ8xOC
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Most common need for desensitization drugs in Rheum are IV drugs. Infliximab, Rituximab and Tociluzimab. If severe reaction desensitize and if mild premeditate ex antihistamines and steroids if needed @RheumNow #RWCS2020 https://t.co/l6SWUPljbZ
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Mast Cell Activation Syndrome. Learn it. It exists but maybe more pts think they have it than really do. Rx with mast cell stabilization. MCAS has tryptase at a high level. Input for dx Dr A Postolova #RWCS2020 @RheumNow https://t.co/mz5z2o1z8p
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UPA worked quickly without new safety signals noted in SELECT AXIS for AS. Drs. Ruderman and Kavanaugh #RWCS2020 @RheumNow @RWCSmtg https://t.co/g2wkLmDtd9
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Packed audience at great rheum mtg. Practical. Great interaction. #RWCS2020 @RheumNow https://t.co/UErbxolatV
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Invert the topical to mild systemic Rx and beyond for atopic dermatitis if severe. Stop the cytokine and itch. Use dupilumab. MAB to IL4 receptor. Also approved in asthma. Lots more drugs coming George Martin #RWCS2020 @RheumNow https://t.co/sJxfflJX5T
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Get JAKed about potential new Rx for atopic dermatitis- 3 early JAKi RCTs says Dr George Martin #RWCS2020 @RheumNow https://t.co/xMR2884fCt
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Atopic dermatitis has different drivers in age and ethnic groups but it is a Th2 disease. JAK1 is impressive and downstream cytokines. Itch is a big deal. Dr George Martin #RWCS2020 @RheumNow https://t.co/wK0pL8HXwt
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Topicals for psoriasis and maybe atopic dermatitis. Topical JAKi tofacitinib ointment and ruxolitinib. Topical PDE4 apremilast roflumilast crisaborole. Also tapinarof
More to come. Oral TKY2 also. #RWCS2020 @RheumNow https://t.co/NpxMBn5EBr
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Cutaneous side effects with steroids. Striae are irreversible!! Dr. George Martin #RWCS2020 @RWCSmtg https://t.co/74Gp7Xm4tx
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How long will they last? Vast majority of TKR or THR (>70%) will last 25 yrs. Failure is usually for infection or fracture. Dr Wm Bugbee #RWCS2020 @RWCSmtg https://t.co/XyGmeiiQTu
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Trends in periop Rx of hip and knee replacement. Little or no narcotics, pain cocktail, tramexamic acid to reduce blood loss & outpt THR ant approach in low risk pts Dr zen Bugbee #RWCS2020 @RheumNow https://t.co/Ky1rD6uHns
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Adalimumab seeems better than infliximab Behcet’s uveitis. Alvin Wells #RWCS2020 @RheumNow https://t.co/dYrKyNjASB
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In general high volume hip & knee replacement orthopods have better outcome. Surrogate for skill? No always warns Dr Wm Bugbee #RWCS2020 @RheumNow https://t.co/L6DhPZ6sBJ
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Best predictor of knee flexion after a knee implant is their flexion before surgery, not the implant Dr Wm Bugbee #RWCS2020 @RWCSmtg https://t.co/CtQNKaFzaP
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Medicare, economics and entrepreneurialism are driving the trend towards patient joint replacement. Dr Wm Bugbee #RWCS2020 @RWCSmtg https://t.co/aIf1GnefyC
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The changing have of orthopedics in Rheumatology Dr Wm Bugbee #RWCS2020 @RWCSmtg https://t.co/M5NdVKEqeq
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