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Update on low-dose glucocorticoids in SLE

d Md Yuzaiful Md Yusof, MRCP(UK), PhD

Glucocorticoids (GC) have been the mainstay of treatment in SLE for nearly three quarters of a century. GC induce a range of anti-inflammatory effects, quickly relieve some symptoms and lower mortality in some life-threatening flares. However, they also have multiple side effects that limit the duration of treatment, as well as the dose used. Accordingly, the 2023 EULAR recommendations for SLE set a target dose of ≤5mg/day. Is low dose GC an achievable target?

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Achieving drug-free remission in axSpA

d EurekAlert!

A clinical trial in early axial spondyloarthritis (axSpA) demonstrated sustained inactive disease status in over 60% of patients.

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Choices in GCA

d David Liew, FRACP

There are a number of diseases where new biologic and targeted synthetic therapeutic options are coming online, and the temptation will be to consider them all equally. GCA is one of those diseases.

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Difficult-to-treat RA: are we any closer to predicting who is at risk?

d Mrinalini Dey, MD

It is almost four years since EULAR published its definition of difficult-to-treat (D2T) rheumatoid arthritis (RA) (1). This marked a formal recognition of the group of patients who, despite the advances in pharmacological therapy for RA, remain symptomatic.

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Can we prevent psoriatic arthritis? PsA affects up to 30% of PsO patients. Understanding factors that lead to PsA helps in early interventions. Most PsA patients have preceding PsO. https://t.co/03H4YrvxMe https://t.co/efUVaccSHn

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Dr. John Cush RheumNow ( View Tweet)
Summary of #EULAR2024 #ClinicalPearls JAKi have expanding disease data ✅ #GCA w #UPA ✅ Awaiting data in #SLE w #UPA & #Deucravacitinib ✅Use in #JIA ✅No new safety signals @rheumnow @eular_org

Janet Pope Janetbirdope ( View Tweet)

EULAR 2024: New drugs for RA? Abiprubart is an Abatacept distant relative, targeting T cell activation through a different target/molecular interaction (CD40/CD154). https://t.co/3wAGjfCdcN https://t.co/2YK2OeIVZK

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Dr. John Cush RheumNow ( View Tweet)
EULAR 2024 - Day 1 Report https://t.co/LpYxUP8d7e https://t.co/5zwc0HsZZ8

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Dr. John Cush RheumNow ( View Tweet)
RheumNow’s expanded coverage of the #EULAR2024 annual meeting is sponsored in part by Bristol Myers Squibb & UCB. All content is chosen by RheumNow & its faculty.

Dr. John Cush RheumNow ( View Tweet)

RheumNow’s expanded coverage of the #EULAR2024 annual meeting is sponsored in part by Bristol Myers Squibb and UCB. All content is chosen by RheumNow & its faculty.

Dr. John Cush RheumNow ( View Tweet)

How many #autoantibodies Does one need in #rheumatoid #arthritis Need 4 citrullinated peptides Covers off 97% of IgG CVP2 ACPAs #EULAR2024 @RheumNow @eular_org https://t.co/LNFGuFXGrC

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Janet Pope Janetbirdope ( View Tweet)

Once in remission with #rituximab in #GPA How long to resize 500 mg q6 mo for 4 years? ?longer ?less #EULAR2024 @eular_org @RheumNow https://t.co/G4kU3v81je

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Janet Pope Janetbirdope ( View Tweet)

Telespa - telemonitoring in AxSpA « minimal impact on disease control « never examine a patient again , never find any pathology outside of joints, remote SpAologists, no longer physicians - easy to train rheumatology nurses to do our jobs @RheumNow #EULAR2024

Peter Nash drpnash ( View Tweet)

PMR has distinct patterns on MRI shoulder, possibly helping diagnosis. #EULAR2024 OP0248 @RheumNow also @bmj_rmdopen https://t.co/pS5kO5OQRW where they say: "Similar to our prior findings... the target of inflammation in PMR is the outer covering of a tendon, the peritendineum" https://t.co/5pu1Xiku3h

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David Liew drdavidliew ( View Tweet)
EULAR 2024 Highlights: Saturday’s Recap with RheumNow https://t.co/BlOsbr9lYB

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Dr. John Cush RheumNow ( View Tweet)

#EULARBEST RCT of #upadacitinib in #GCA It works to steroid spare 15 mg > 7.5 mg in outcomes Both >>placebo Ethically PBO had slower #prednisone taper Similar to #TCZ data What to choose in GCA IL6i IL17i JAKi @eular_org @RheumNow LBA0001 https://t.co/gy0TEiHxjo

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Janet Pope Janetbirdope ( View Tweet)

Does B Cell Depletion Matter? Dr. Yuz Yusof interviews Dr. Ed Vital regarding abstract OP0077 at Eular 2024 in Vienna, Austria. https://t.co/IjxGWWjoGD https://t.co/GwLjB4Z7ub

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Dr. John Cush RheumNow ( View Tweet)
Telespa - telemonitoring in AxSpA « minimal impact on disease control « never examine a patient again , never find any pathology outside of joints, remote SpAologists, no longer physicians - easy to train rheumatology nurses to do our jobs @RheumNow #EULAR2025

Peter Nash drpnash ( View Tweet)

#Scleroderma #recommendations #Rayanud’s #vasculopathy #digital #ulcers CCB PDE5i IV iloprost Bosentan for Digital ulcer prevention <not approved in NA> #EULAR2024 @EUSTAR_org @RheumNow #SSc https://t.co/9c2cHAptIC

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Janet Pope Janetbirdope ( View Tweet)
SHR032 chinese JAK1 inhib AS and PsA - typical efficacy and safety - looks like smells like tastes like JAK1 inhib but no zoster listed or acne, or anaemia with higher dose, 1 mace 1 vte @RheumNow #EULAR2024

Peter Nash drpnash ( View Tweet)

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