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Scary IPAF

Daric A. Mueller, PA-C

Interstitial pneumonia with autoimmune features (IPAF) describes patients who have interstitial lung disease (ILD) plus clinical, serologic, or morphologic features of autoimmunity but who do not meet criteria for a defined connective tissue disease.

Daric Mueller, PA-C Tweet
rheumPAC
Abstract #1619 Retrospective look at mortality and healthcare utilization trends in interstitial pneumonia with autoimmune features (IPAF): Within 5 years of IPAF incidence: 42% died 69% hospitalized 89% w/ ED visit 14% newly Rx'd O2 #ACRbest #ACR26 @RheumNow
Adela Castro Tweet
AdelaCastro222
SjD diagnosis: -No test w/ absolute specificity -Sicca does not need to be present for a dx. -Extraglandular manifestations also play role in dx: ILD, purpura, hypergammaglobulinemia, low complements etc -Symtom burden not always correlate with DAI -Sicca can be absent in certain https://t.co/8HG69extNv
Janet Pope Tweet
Janetbirdope
#dcSSc active Early allogenic #CAR-T -initial dosing had #mRSS drop of 16pts (L Chung) Well tolerated in vivo #CAR-T #CD19 N=3 SSc + for #skin & #lung 🫁 from China + in SLE NEJM just published closer to scalable Rx vs autologous! #ACR26 @RheumNow @ACRheum #0223, 0225
Daric Mueller, PA-C Tweet
rheumPAC
Mortality in IIM-ILD: frontloaded but survival + improvement possible! 2 year mortality outcomes in a newly diagnosed IIM-cohort (n=41), 15% died @ median time of 8.5 months. Of survivors, only 13.3% progressed, 46.7% improved as measured by % pred FVC. #ACR26 @Rheumnow
Eric Dein Tweet
ericdeinmd
#ACR26 @RheumNow Ab#0475 - AutoAb in ILD 48 pts analyzed Anti-Sa Ab in 15%, Anti-CarP 25% ILD in 8% pts, erosive RA in 15% Sa - higher prev of ILD (43 v 2%), higher erosion but not signif CarP not assoc w ILD, erosive disease (though previous associations have been reported)
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