Still for me the most interesting bit from the GLORIA study (PNL 5 add-on in RA) is the coming off of it. Patients were able to come off their long-term low-dose prednisolone. No Sx/biochem differences vs placebo. True #squadgoals for rheumatologists ABST2000 #ACR22 @RheumNow https://t.co/eQLcgqA1SN https://t.co/RGTCrMhld7

• https://twitter.com/drdavidliew/status/1532665246007144448

Cumulative dose and exposure to methotrexate were not predictors of hepatic fibrosis. Hepatic fibrosis as measured by elastography associated with daily EtOH use. #ACRBest Abs#2147 @RheumNow #ACR22

Peritonitis of the #FMF - misdiagnosed as acute abdomen Acute appendicitis is the leading cause of acute abdomen in FMF Turkish study 1655 #FMF pts 15.8% appendectomy rates! CRP ineffective for differing FMF from appendicitis :( @RheumNow #ACR22 abst#1839

Factors associated with non-achievement of MDA in PsA pts receiving golimumab: Baseline tender joint count, fibromyalgia, older age, smoking, high BMI Abs#2109 @RheumNow #ACR22 https://t.co/dEzQxVtavh

‼️‼️Frailty ‼️‼️ 👉Important predictor of serious infxn in RA pts on b- or tsDMARD irrespective of age ‼️‼️ @NamrataRheum illustrating yet another reason why it is so NB to evaluate 4 frailty in ALL (incl young) pts with RA #GeriRheum Abst2218 @RheumNow #ACR22 https://t.co/J4XQFmVoUw

While there are limitations to this study (respondents over childbearing age, white, educated, insured), within 2 months of @USSupremeCourt3's overturn of Roe v Wade, 1 in 17 MTX pts experienced a barrier to getting rx filled. ABS L09 @RheumNow #ACR22 https://t.co/WuikwO1bZ9 https://t.co/4Ve0zAVxbG

• Impact on Access to Methotrexate in the Post-Roe Era - ACR Meeting Abstracts

Early psoriasis and enthesitis response in PsA pts treated with guselkumab predicted longterm clinical response including MDA, DAPSA LDA, DAPSA50, DAPSA remission. Pts w/o early response, only half achieved remission Abs#2115 @RheumNow #ACR22 https://t.co/dnsQcp7cEq

BKZ showed clinically meaningful improvements in efficacy outcomes in bDMARD-naïve PsA pts at Wk 16 through wk 52. No new safety signals. ABS L02 #ACR22 @RheumNow https://t.co/Dph32O7NWG https://t.co/d7Yq3JISyF

• Bimekizumab Treatment in Biologic DMARD-Naïve Patients with Active Psoriatic Ar…

I think this has changed my mind! Does RA benefit from changes in diet & exercise? RCT Reade @amsterdamumc n=77 mod active RA https://t.co/5Iw6hYJzGK for 16w: whole food plant-based diet/exercise/stress management 0.9 improvement in DAS28 vs placebo! ABST1998 #ACR22 @RheumNow https://t.co/u10RqmPMPd

• Home - Plants for Health

PsA bDMARD "ranking" system by systematic literature review looked at 30 RCTs Highest probability of achieving ACR20 and PASI90: infliximab, golimumab and bimekizumab #ACRBest Abs#2123 @RheumNow #ACR22 https://t.co/KpW0p2KAQZ

🔥PrEP 4 SARS-CoV-2🔥 ➡️casirivimab/imdevimab ⚡️Detection @ D1 and stabilisation up to D30 of serum and saliva Abs in IMID pts who failed response 2 COVID vax. ❓role in preventing severe infxn in high risk pts refractory 2 vax #ACR22 @RheumNow Abst 2195 @Dr_David_Simon https://t.co/Zd00P5l363

Abstr # 1878 looked at biomarkers assoc w/ MRI muscle inflammation in #IIM - Of the potential cytokines, IL-7 strongly correlated with muscle damage on MRI thigh bilateral @RheumNow #ACR22 #Myositis https://t.co/3i3C2EGtFM

Smartphone app (FM-ACT) - self guided 8 chapters of structured lessons, mindfulness practices and activities w/ paced exercise and behavior change proved beneficial after 12 weeks. Improvement in all areas: pain, sleep, psychological wellbeing Abs#2235 @RheumNow #ACR22 https://t.co/wNhIw4pdJu

61pts with #FMF on Canakinumab - single center in Turkey 35% no attacks attack frequency decreased in 55% no response in 10% - VAS score and inflammatory markers significantly improved #ACR22 @RheumNow abst#1834

#abst0405 #ACR22 @RheumNow Post hoc of ph2/3 trials TOFA for AS: AEs/SAEs ⬆️ in pts w/BMI < 25 kg/m2 vs other BMI categories. Most frequent AEs (≥ 5% of pts) nasopharyngitis, URI& arthralgia. Δ from BL in LFTs similar, while % change from BL in lipid levels ⬆️ in Tofa vs PBO pts https://t.co/WmXD8uVK58