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Microbioime analyses of cancer patients suggests over abundance of fungi, expecially transcriptionally active Candida a

Dr. John Cush RheumNow

3 years 11 months ago
Microbioime analyses of cancer patients suggests over abundance of fungi, expecially transcriptionally active Candida and is associated with gastrointestinal and lung cancers. Candida DNA is also predictive of reduced survival in GI cancers https://t.co/JKaffWZqy7 https://t.co/suByUP6anA
The NY Times has reported results of a study showing that nearly two-thirds of doctors are experiencing at least one symptom of burnout, with a marked increase since the onset of the pandemic.  These findings suggest that burnout rates amongst US doctors have risen to alarming levels.
A recent doximity report shows how rheumatology salaries increase by years in practice.  Their salary estimates are based on Doximity acquired data from over 200,000 physicians, along with publicly-available career and salary data from the U.S. Bureau of Labor Statistics, the U.S. Census. Rheumatologists tend to earn their highest salaries after gaining 30-39 years of experience. 
Comprehensive full-read review of #Baricitinib trials in treating COVID-19. 24 studies (16 retrospective, 5 prospective

Dr. John Cush RheumNow

3 years 11 months ago
Comprehensive full-read review of #Baricitinib trials in treating COVID-19. 24 studies (16 retrospective, 5 prospective, 3 case control) studies & 3 larged RCTs show Bari as 24-38% better than comparators/SOC (few showed no change in mortality) https://t.co/pps1Du9rEt https://t.co/ZEDiHwZ5po
Female physicians were more likely to be called by their first names in electronic medical record (EMR) patient portal messaging, researchers found.
8 pts w/ Refractory Skin Dermatomyositis Rx w/ open label APREMILAST, @ 3 mos 7/8 pts responded w/ drop in CDASI (-12.9

Dr. John Cush RheumNow

3 years 11 months ago
8 pts w/ Refractory Skin Dermatomyositis Rx w/ open label APREMILAST, @ 3 mos 7/8 pts responded w/ drop in CDASI (-12.9 pts; P < .001). Skin Bx showed downregulation of multiple inflamm pathways (STAT1/3, IL-4), IL-6, IL-12, IL-23, IFNγ & TNFα) https://t.co/V6RZdg9y6V https://t.co/ppSUzlAP4D
PhRMA estimates that 90% of US healthcare spending is on chronic conditions. Currently there are ~800 drugs in developme

Dr. John Cush RheumNow

3 years 11 months ago
PhRMA estimates that 90% of US healthcare spending is on chronic conditions. Currently there are ~800 drugs in development for chronic Dz - with 70 drugs in Ph1-3 development for arthritis: OA, RA, PsA, Gout (>1/3 in Phase 3) https://t.co/cozMhQI3UH https://t.co/uZe6L2ph87
Hamilton, ON (Oct. 4, 2022) – Patients can recover from orthopedic surgery just as well without using opioid-based painkillers, says a McMaster University and Hamilton Health Sciences (HHS) study published by the Journal of the American Medical Association (JAMA).
The University Of Pennsylvania has recv a $50 Million Gift (from Stewart &amp; Judy Colton) to further develop the Autoi

Dr. John Cush RheumNow

3 years 11 months ago
The University Of Pennsylvania has recv a $50 Million Gift (from Stewart & Judy Colton) to further develop the Autoimmune Disease Research program at Penn’s Colton Center for Autoimmunity. 6.4% of women and 2.7% of men have autoimmune disease https://t.co/gMdoiZFTdB https://t.co/BZHn1mSmHU
A retrospectively cohort study of 147 r-AxSpA patients looked at secukinumab retention, which was 55% at 12 mos. Obesity

Dr. John Cush RheumNow

3 years 11 months ago
A retrospectively cohort study of 147 r-AxSpA patients looked at secukinumab retention, which was 55% at 12 mos. Obesity was assoc w/ a lower rate of SEC D/C (29% v 50%, p = 0.013). Yet multiple TNFi had higher rate of SEC D/C [HR 1.99] https://t.co/OZIZoTROZS https://t.co/M99ANDGzv9
Juvenile idiopathic arthritis (JIA) may start in adolescence and extend into adulthood. This report of the Nordic experience shows that both pediatric and adulty rheumatologists need to develop "transition" practices; without such an approach considerable gaps in healthcare will befall these JIA patients. 
JAMA Oncology reports in 1st 10 mos of pandemic, 16,500 cancer pts died from COVID+complications; w/ signific more COVID

Dr. John Cush RheumNow

3 years 11 months ago
JAMA Oncology reports in 1st 10 mos of pandemic, 16,500 cancer pts died from COVID+complications; w/ signific more COVID-19-related cancer deaths than cancer deaths w/o COVID-19 in blood CA(23% v 10%) & prostate CA (12% v. 5.5%) https://t.co/036VU8H1vx https://t.co/tWh8749pTx
Microbioime analyses of cancer patients suggests over abundance of fungi, expecially transcriptionally active Candida a

Dr. John Cush RheumNow

3 years 11 months ago
Microbioime analyses of cancer patients suggests over abundance of fungi, expecially transcriptionally active Candida and is associated with gastrointestinal and lung cancers. Candida DNA is also predictive of reduced survival in GI cancers https://t.co/YoMOvvskqz https://t.co/6hC6Y4YAc1
While it is known that smoking ups the risk of developing RA, its effect on outcomes in those with established rheumatoid arthritis (RA) is less known.  A report from an early arthritis registry shows that current smoking increases disease activity and lowers health-related quality of life.
New look at fibrosis in scleroderma finds low levels of the antifibrotic protein, endostatin &amp; Cathespin L. In vitro

Dr. John Cush RheumNow

3 years 11 months ago
New look at fibrosis in scleroderma finds low levels of the antifibrotic protein, endostatin & Cathespin L. In vitro studies show a deficiency of Cathepsin L that should lead to its activation of antifibrotic endostatin - possibly a new Rx strategy for SSc https://t.co/qaLN0PVnLO https://t.co/TDK4sBZMV0
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