Dr. John Cush RheumNow
3 years 11 months ago
#Gout Guidelines--> great outcomes! French study of 300 pts; 95% followed French Rx Guidelines, T2T SU < 6 mg/dL in 59% @6mos, 79% @24 mos & @2 yrs hald were Rx w/ allopurinol (313 mg/d) and 48% febuxostat (84 mg/d) https://t.co/iQ9NvHJXd8 https://t.co/2tkBWrHY32
Dr. John Cush RheumNow
3 years 11 months ago
"Double blind" an interesting read (Ann Int Med) of early COVID w/ no known effective therapy, doctor trepidation & and the bravery/will of sick ICU COVID pts as they consent to to enroll in the blinded ACTT trial w/ remdesivir https://t.co/N2bZq0JDmn https://t.co/iPLnNtQoER
Reuters has reported the results of a Congressional report showing the economic toll of the opioid addiction and overdose crisis on the United States reached nearly $1.5 trillion in 2020 alone and is likely to grow.
There is a growing body of evidence demonstrating efficacy and safety of JAK inhibitors in patients with moderate-to-severe psoriasis and psoriatic arthritis, according to a systematic review in BMC Rheumatology.
Using long-term patient data from the BARFOT study of early rheumatoid arthritis (RA) patients, researchers at the Karolinska Institute have shown that use of the ACR-1987 classification criteria was highly precise.
Dr. John Cush RheumNow
3 years 11 months ago
Study of 67 OA TKR pts looked for CPPD - defined as "appears as linear/punctate opacities w/in cartilage, synovium, Jt capsule or tendons/entheses". Xrays had specificity of 92%, sensitivity 54%, PPV 88%, NPV 66% (needs to be distinguished from BCP) https://t.co/Nd9FZKyOHy https://t.co/m9PYofGE04
Dr. John Cush RheumNow
3 years 11 months ago
Long term results of KEEPsAKE 1 and 2, RCTS of SKYRIZI (IL-23 inhibitor) in active #PsA pts were presented at EADV mtg in Milan. At wk 100, showed more than half of PsA patients achieved PASI 90 & ACR 20 responses. https://t.co/5upWNItwGy https://t.co/RMwDYVubOk
Dr. John Cush RheumNow
3 years 11 months ago
Metanalysis of 57 studies, 227,812 RA & 64,290 OP pts. Finds the OP prevalence in RA to be 27.6% (95%CI 23.9–31.3%). Despite significant advances in prevention, treatment & imaging, OP prevalence remain high. https://t.co/SxAJ8cGU8b https://t.co/91D6rtW9bF
Short-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a first-time hospitalisation for heart failure in patients with type 2 diabetes, according to research presented at ESC Congress 2022.
What may seem like a prudent approach to treatment of inflammatory bowel disease (IBD) in pregnant women actually represents an overabundance of caution, suggested researchers who found no increased risk from tumor necrosis factor (TNF) inhibitors.
Dr. John Cush RheumNow
3 years 11 months ago
3 Large cohort (OAI, MOST, CHECK) looked at 9683 knees (incidence cohort) & 6075 knees (progression cohort) showing increase in BMI assoc w/ incidence (OR 1.05) & progression (1.05). BMI also assoc w/ degeneration & JSN hip & medial knee https://t.co/VAU2UJRQ8O https://t.co/QBl2wt0FrN
Dr. John Cush RheumNow
3 years 11 months ago
Is there a link between PsA & autoinflammatory disease? Dr. Cush reviews a recent study of 120 #PsA patients in our latest podcast.
https://t.co/b15zmfXACa https://t.co/aCY08xXtPw
Dr. John Cush RheumNow
3 years 11 months ago
ASBMR 2022 study shows Patients w/ serum ferritin > 1000 µg/L or Dx hemochromatosis or thalassemia — were 60% more likely to have an osteoporotic fracture (2X risk vertebral Fx) during an up to 10-year follow-up https://t.co/uLf8zTiMml https://t.co/9KnApUxxTF
Dr. John Cush RheumNow
3 years 11 months ago
VTE Risk from Swedish Rheumatology Quality Register - VTE Prevalnce/1000PY TNFi 5.15; JAKi 11.33; Gen Pop 3.3. VTE adj HR JAKi vs TNFi =1.73 (1.24, 2.42); PE HR 3.21 (2.11, 4.88) and DVT HR 0.83 (0.47,1.45) https://t.co/WclcFpX3aI https://t.co/r1FXSZNcYJ
Dr. John Cush RheumNow
3 years 11 months ago
Analyses of data from the Nurses Health Study (1986-2016) & NHSII (1989-2017) cohorts shows chronic low sleep duration (< 5hrs/night vs >7hr/night) was assoc w/ increased SLE risk (adj HR 2.47). Low sleep also assoc w/ body pain(2.13), depression(HR 2.82) https://t.co/I9oCDQyulz https://t.co/vjRFDXf0EZ
