The revitalizing powers of sleep are numerous but what are the consequences to inadequate sleep? A current report in the Journal of Experimental Medicine shows the connection between sleep and immune function as measured in mice and humans; specifically, a good night’s sleep promotes normal production and programming of hematopoietic stem cells.
ACR members along with rheumatology patients gathered on Capitol Hill and urged federal lawmakers to support the HELP Copays Act, Safe Step Act, and Improving Seniors’ Timely Access to Care Act.
Dr. John Cush RheumNow
3 years 11 months ago
IL-18 is a proinflammatory cytokine involved in innate &adaptive immune responses. IL-18 is a key mediator in autoinflammatory diseases, MAS, Still’s disease. Serum IL-18 levels may be useful in diagnosis and monitoring of disease activity https://t.co/IB9CwbILD9 https://t.co/TWNnjJyR2Z
Dr. John Cush RheumNow
3 years 11 months ago
Medicare (1,654,862 pts) cohort matched study included 3.6% w/ rheumatic IMIDs w/ MI. Rheum IMIDs were younger, women, w/ non–STEMI, less angiography/Stent/CABG & have higher mortality (aHR 1.15), CHF (1.12) & recurrent MI (1.08) https://t.co/SxemjO7GA2 https://t.co/VKg1f4yd2M
Dr. John Cush RheumNow
3 years 11 months ago
Cancer Risk with Scleroderma
Spanish Scleroderma Registry examined a large cohort of systemic sclerosis (SSc) patients showing an increased cancer risk, especially breast, lung, hematologic and colorectal cancer.
https://t.co/9w53NO3AsU https://t.co/bSkFhTN3v2
Dr. John Cush RheumNow
3 years 11 months ago
Is PMR the Next Indication for Tocilizumab?
About half of patients with steroid-dependent PMR were able to get off steroids altogether when they were started on tocilizumab (Actemra) infusions, a randomized phase III trial showed.
https://t.co/Ea7XIqViRj https://t.co/h65OSjoytg
Dr. John Cush RheumNow
3 years 11 months ago
Clinical Profiles Seen with NXP-2 Antibodies
A recent review of the myositis associated autoantibody NXP-2 profiles its clinical associations with dermatomyositis (DM), calcinosis, severe myositis and, in some reports, with cancer.
https://t.co/oCgb1f2Avw https://t.co/rnMa4jHhNy
Dr. John Cush RheumNow
3 years 11 months ago
Yoga Fails to Benefit Knee Osteoarthritis
The Annals of Internal Medicine has published a study showing online yoga education and an unsupervised yoga program may improve physical function did not improve knee pain after 12 weeks and 24 weeks.
https://t.co/9n31mTpudX https://t.co/WettcMpBLi
Dr. John Cush RheumNow
3 years 11 months ago
IL-6i in Behcets? Lit Review finds 25 articles papers, 74 pts (31 TNFi naive, 45 TNFi prior Rx). Pts Rx w/ tocilizumab IV. TCZ given for vascular, CNS , ocular & mucocutaneous. TCZ was effective in 87% TNF naive & 80% in TNFi Experienced pts. https://t.co/u1jnR9gb1L https://t.co/Rkqch4MVWi
Dr. John Cush RheumNow
3 years 11 months ago
Is there link between PsA & autoinflammatory Dz? Study of 120 #PsA pts found 31% w/ AID gene variants (AP1S3, PLCG2, NOD2, NLRP12, all monoallelic variants adn 1/2 genes assoc w/ autosomal dominant disorders. https://t.co/1cVFErPV6o https://t.co/QtRHrZJLJI
Dr. John Cush RheumNow
3 years 11 months ago
Hydroxychloroquine Dosing and SLE Flares
JAMA cohort study examining HCQ dosing in patients with SLE suggests that HCQ doses of 5 mg/kg per day or less, was associated with a higher risk of lupus flares, including moderate or severe lupus flares.
https://t.co/1krevZo64c https://t.co/XEybtcFvNR
Dr. John Cush RheumNow
3 years 11 months ago
STAR-RA study - real world claims data shows tofacitinib doesnt increase malignancy risk. Study of 83,295 pts (10,504 TOFA). Risk of malignancy w/ TOFA not increased (HR 1.01) w/ RWE or RCT-duplicate cohort (HR 1.1; 95% CI 0.85, 1.62) https://t.co/9YWmXBTkWf
Dr. John Cush RheumNow
3 years 11 months ago
RINOMAX Trial studied single dose of 500 mg rituximab IV in myasthenia gravis - 47 MG pts randomized to RTX or PBO, after 4 mos RTX response (71% vs 29%) superior to PBO. Further studies are needed https://t.co/ffko7uMpk7
Dr. John Cush RheumNow
3 years 11 months ago
Colchicine vs cimetidine in PFAPA (Periodic fever, aphthous stomatitis, pharyngitis, adenitis) syndrome. 72 pts given COL vs CIM x 3 mos: # of febrile attacks was significantly decreased by both Rx (noninferior to each other) https://t.co/HkmzwGNwFC
Dr. John Cush RheumNow
3 years 11 months ago
Heavy Metal Rheumatology 🤘
https://t.co/4fkwOsH2yf https://t.co/otQP9a6h6S
