Dr. John Cush RheumNow
4 years ago
Spinal cord stimulation is a $2-3billion market, despite limited efficacy. A placebo controlled trial of spinal cord burst stimulation, in 50 pts w/ chr radicular pain after lumbar surgery, showed no significant benefit in back pain–related disability. https://t.co/aRN5sRbqFx https://t.co/A37LWaYEGw
Pregnancy in systemic lupus erythematosus (SLE) is fraught with problems of adverse pregnancy outcomes, more pregnancy loss and birth defects. Now a study of SLE pregnancies exposed to belimumab (BEL) shows and expected rate of pregnancy loss but a variable rate of birth defects.
Data were derived from the BEL clinical trials, the Belimumab Pregnancy Registry (BPR), and postmarketing/ spontaneous reports up to 8 March 2020.
In a recent analysis published in Arthritis & Rheumatology, people at risk for rheumatoid arthritis (RA) and those with the disease had elevated blood levels of antibodies against a Prevotella copri (Pc).
Dr. John Cush RheumNow
4 years ago
Dr. Kent Kwoh and Researchers at the University of Arizona Arthritis Center have been awarded a $3.4 million grant from the National Institutes of Health to undertake a study that seeks to identify determinants of rapid knee deterioration in OA https://t.co/EodUXk6FDp https://t.co/bX2k5c7lR9
Dr. John Cush RheumNow
4 years ago
NEJM: Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis - 70yoM with 6-month history of dysphagia. Compression of the hypopharyx by large cervical osteophytes was seen in a videofluoroscopic swallowing study https://t.co/AVDXPzhfjd https://t.co/7TwY0CGaxb
Dr. John Cush RheumNow
4 years ago
Cross-sectional study of 291 PCPs shows that increased electronic health record (EHR) time was associated with a significantly greater liklihood of meeting patient target goals for Hgb-A1C, HTN control and breast cancer screening https://t.co/mLdoHM9N7O https://t.co/li6QD5jq7F
Dr. John Cush RheumNow
4 years ago
Arthritis Clinical Trials Comparison Grid
Use this resource to keep track of your clinical trials and key information needed when communicating with patients about a drug study.
https://t.co/9z42zfr1Fx https://t.co/dYAjOVvTaW
Add "hard rock" mining to the list of occupations associated with high rates of rheumatoid arthritis (RA), a new study indicated, with silica exposure the presumed malefactor.
Scientists at deCODE genetics a subsidiary of Amgen report in Arthritis & Rheumatology that a novel plasma protein (cartilage acidic protein-1; CRTAC1) is a potential biomarker of osteoarthritis (OA) through its association with OA risk and progression to joint replacement.
Dr. John Cush RheumNow
4 years ago
EMA CHMP issued a positive opinion on the safety of Filgotinib, a selective JAK1 inhibitor, based on testicular safety data from the MANTA & MANTA-RAy studies. Gilead withdrew filgotinib from US market w/ FDA concerns on testicular safety in 12/20 https://t.co/38xOWb1zJi https://t.co/jPUy6H1QQN
Dr. John Cush RheumNow
4 years ago
Urine proteomics on 54 SLE pts in the Belimumab–Lupus Nephritis trial, compared responders (n 31) v non-responders (n 22), on BEL or SOC. Reduction in urinary CD163 was strongly associated with complete renal response @wk52 & CD23 @wk24 https://t.co/PrXaJq6h0E https://t.co/IWREF9VmZ8
Dr. John Cush RheumNow
4 years ago
A Review of AOSD - Adult - Onset Still's Disease
https://t.co/VvWX5t3WPY
@Stills_Now https://t.co/uEoCjhViRP
Dr. John Cush RheumNow
4 years ago
In this week's special podcast, Dr. Jack Cush offers a primer on rheumatology clinical trials, answering the question: should you be involved in research and clinical trials in rheumatology?
https://t.co/yuCAmwsoAY https://t.co/vC835UUxzI
Dr. John Cush RheumNow
4 years ago
Do you renal Bx your #SLE pts? Study of 277 SLE pts w/ US-guided percutaneous renal bx showed bleeding complications post biopsy to be 19.9% (minor 13%; major 7%); risk higher w/ thrombocytopenia (OR 7.12)low eGFR (OR 3.5) https://t.co/vYYChuGdSN https://t.co/kULTEnNYC9
Dr. John Cush RheumNow
4 years ago
NEJM: 70 yoWM w/ 3-wk temporal headaches, jaw pain with chewing, temporal artery tender and thickened, but NO vision Sxs. a 15, CRP 24 mg/L. and Doppler US showed “halo sign” . Temp art Bx confirmed the Dx of GCA https://t.co/ayPcVKctEA https://t.co/g3iP0Akbzs

