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Dr. Peter Nigrovic asserts the division between pediatric and adult arthritis is senseless and has no firm biologic basi

Dr. John Cush RheumNow

4 years 8 months ago
Dr. Peter Nigrovic asserts the division between pediatric and adult arthritis is senseless and has no firm biologic basis. Instead we should consider pts as sero- positive or negative, Systemci or Spondyloarthropathy. @UTSWRheum https://t.co/zx5oQmUQ6Y
van Vollenhoven et al strategies onT2T in SLE
1) Choose a Target; treat, monitor, adjust
2) LLDAS & DORIS remission

Dr. John Cush RheumNow

4 years 8 months ago
van Vollenhoven et al strategies onT2T in SLE 1) Choose a Target; treat, monitor, adjust 2) LLDAS & DORIS remission are good targets 3) T2T trials needed w/ current Rx & new biologics & sm molecules 4) LLDAS & DORIS as outcomes in clinical trials https://t.co/aTq398iaSD https://t.co/yWlp4vY7kh
UTSW Rheum Grand Rounds with Dr. Peter Nigrovic on systemic JIA in children and adults; yes, its the same disease with t

Dr. John Cush RheumNow

4 years 8 months ago
UTSW Rheum Grand Rounds with Dr. Peter Nigrovic on systemic JIA in children and adults; yes, its the same disease with the same features. @UTSWRheum https://t.co/C7eBFjnDIi
Network metanalysis (28 RCTs, 12 504 pts) of Biologics & small molecules therapy in active ulcerative colitis. Up

Dr. John Cush RheumNow

4 years 8 months ago
Network metanalysis (28 RCTs, 12 504 pts) of Biologics & small molecules therapy in active ulcerative colitis. Upadacitinib 45 mg qd ranked 1st (RR 0.73) vs PBO, infliximab 5 mg/kg & 10 mg/kg ranked 2nd & 3rd. UPA > TNFi at remission. https://t.co/PPNkfXiJSL
A prospective primary care study of patients at-risk for inflammatory arthritis (IA) showed that progression to IA was most likely in those with high anti-CCP antibody titers levels and involvement of the hands/feet/ IA. Interestingly, progression to IA was also seen in those who were negative for CCP with hand or knee pain.
Who is Your Glue?
I’ve often talked about the nurses in my clinic as being the glue, the clinic glue, my personal glue. Without them, the day and task would never go as well and just might crash and burn, if not for their steadying influence. Surely you have used or heard of “<the person> who was the glue that held the family together”.
UCB announced top-line interim analysis results from their Phase 3 "BE MOBILE 1" study, that demonstrated the efficacy o

Dr. John Cush RheumNow

4 years 8 months ago
UCB announced top-line interim analysis results from their Phase 3 "BE MOBILE 1" study, that demonstrated the efficacy of bimekizumab, a dual IL-17A and F inhibitor, in adults with active non-radiographic axial spondyloarthritis (nr-axSpA). https://t.co/FylgQ30Dva https://t.co/XJ4y0U60hu
How Bad and How Far? CDC says to date, in the USA, there have been 6,715,937 COVID cases and 850,575 deaths from COVID-1

Dr. John Cush RheumNow

4 years 8 months ago
How Bad and How Far? CDC says to date, in the USA, there have been 6,715,937 COVID cases and 850,575 deaths from COVID-19. A total of 249,393,487 (75.1%) have recv at least one VAX dose, 209,312,770 (63%) fully VAX, 38.7% had a booster dose https://t.co/M9fYWL80ae
Using SKG mouse model of adjuvant induced SpA and enthesitis, neutrophils, and inducible IL-23, were shown to play an im

Dr. John Cush RheumNow

4 years 8 months ago
Using SKG mouse model of adjuvant induced SpA and enthesitis, neutrophils, and inducible IL-23, were shown to play an important role in early murine spondyloarthritis-related enthesitis. https://t.co/wlHXkNbvR7
192 early arthritis &amp; 693 early arthralgia underwent the MTP-squeeze-test (MTPsqT) &amp; MRI. Synovitis &amp; interm

Dr. John Cush RheumNow

4 years 8 months ago
192 early arthritis & 693 early arthralgia underwent the MTP-squeeze-test (MTPsqT) & MRI. Synovitis & intermetatarsal bursitis (IMB) were assoc w/ MTPsqT. In EA, MTPsqT +, 79% had synovitis or IMB: 12% synovitis, 15% IMB & 52% had both. https://t.co/Ojwb8KkmLu
ASK CUSH ANYTHING!

Have a Rheumatology question or case for Dr. Cush? Record it here and we may feature it on an upcomi

Dr. John Cush RheumNow

4 years 8 months ago
ASK CUSH ANYTHING! Have a Rheumatology question or case for Dr. Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/LAC6XrYEyN https://t.co/POGHk7Ibq2
Patients with ANCA-associated vasculitis (AAV) did not mount durable antibody responses to the SARS-CoV-2 Delta variant after the standard two-dose regimen of the Pfizer-BioNTech vaccine -- and for those taking rituximab (Rituxan) as maintenance therapy, even a third dose wasn't much help.
Today, UCB announced top-line interim analysis results from their Phase 3 "BE MOBILE 1" study, that demonstrated the efficacy of bimekizumab, a dual IL-17A and F inhibitor, in adults with active non-radiographic axial spondyloarthritis (nr-axSpA).
FDA has approved 2 JAK inhibitors for use in severe atopic dermatitis (eczema) - Abbvies upadacitinib (Rinvoq) and Pfize

Dr. John Cush RheumNow

4 years 8 months ago
FDA has approved 2 JAK inhibitors for use in severe atopic dermatitis (eczema) - Abbvies upadacitinib (Rinvoq) and Pfizers abrocitinib (Cibinqo). https://t.co/WpCehmB7Vz https://t.co/qKoqV08Z86
J Rheum reports rheums may not be adequately screening for HBV, HCV when using tofacitinib &amp; tocilizumab, despite re

Dr. John Cush RheumNow

4 years 8 months ago
J Rheum reports rheums may not be adequately screening for HBV, HCV when using tofacitinib & tocilizumab, despite rec's from CDC, AASLD, PI (but not ACR) to do so. TCZ & TOFA had partial screening (45% & 50%) or no screening (26% & 26%) https://t.co/y28kSJ1JgA
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