My video take from yesterday for @RheumNow: 'Tired of Doing Nothing About Fatigue' #ACR21 https://t.co/EXjOibL5s9 https://t.co/cR6r8GdDor

• Tired of Doing Nothing About Fatigue: Dr. David Liew | RheumNow
• David Liew on Twitter: "Fatigue fills us with dread: common, big issue, no…

AxSpA pts who achieve ASDAS low disease activity (LDA) 6 mo after bDMARD initiation ⭐️ 25% achieved ASDAS LDA ⭐️ASDAS LDA achievers were ♂️ + naïve to c/b DMARDs + with PROM / Clinical improvement ⭐️ASDAS LDA non-achievers=depression, uveitis, IBD Abst# 0925 #ACR21 @RheumNow

Turkish study finds that ETN may be negatively associated w/ the development of ADA in AS pts. Abs 0936 #ACR21 #RheumNow @RheumNow https://t.co/z3pYDpp1NN https://t.co/MR1R41rCHV

• Factors Associated with the Development of Anti-drug Antibodies to Tumour Necro…

They're VITAL!🤓 Prof @karen_kc123 presents the results of the RCT (huge population size) showing how 5-yr supplementation with Vit D3 &/or n-3 fatty acids ⬇incident autoimmune dse vs. non-takers. Game changing?! @RheumNow #ACR21 #ACRBest abs0957 https://t.co/X9QaB1B5Ac

PsA impacts many aspects of life. PRO such as VAS pain and HAQ, are commonly assessed. The FACIT-Fatigue scale, ranked the highest by patients. Personalized discussion is vital in assessment and shared decision making @RheumNow #ACR21 Abst#0751 https://t.co/gRfYK4sHc6 https://t.co/f5xjUnXsGQ

• Are Current Patient Reported Outcomes Instruments Optimized to Capture the Enti…

Evaluate effectiveness and Rx survival of different TNFI in cohort of axSpA ⭐️No difference among different TNFI ⭐️No difference between nr-axSpA and AS ⭐️Failure to initial TNFI did not diminish effectiveness or drug survival of subsequent TNFi Rx Abst#0938 #ACR21 @RheumNow

#ACR21 Abst#0588. TNF vs non-TNFi in obese RA pts ⭐️TNFi use ⬆️ disease activity vs ABA in obese pts ⭐️TNFi use ⬆️ activity vs TCZ in non-obese pts ⭐️No diff w RTX, Tofa ▶️Further research needed: Wt-based dosing? SC vs IV? https://t.co/K8WycPTgxW @Rheumnow #ACRBest

• https://bit.ly/3H1GMDI

Abst0897 #ACR21 @RheumNow radiographic progression in AS accelerates w/age, highest at age 30–39 (mean mSASSS change per year 1.148), followed by 40–49 , 20–29,≥50 & least < 20 (0.643). radiographic damage rapidly ⬆️ among 20s w/risk factors:⬆️ CRP &preexisting syndesmophytes https://t.co/tiAgKUyjJq

ORAL Surveillance MACE conclusions: So this is fair: tofacitinib acts as a CV risk factor, there are many others, we need to address CV risk in RA pts. Nevertheless, in terms of MI risk, tofa vs TNFi, if I had one CV risk factor, I know what I'd do. #ACR21 ABST0958 @RheumNow https://t.co/4Z79XtTzl9

For what it's worth, I'm struck by my conversation last week with one RA patient in clinic with stents. 3y ago post-MTX/HCQ had asked for a JAKi first line, immaculate RA response. Listened, no blinking, okay thanks doctor - I'm happy where I am. Next question. #ACR21 @RheumNow

“For many patients, it doesn’t matter if there’s an increased risk, because they don’t want to go to the alternative” - Christina Charles-Schoeman, presenting ORAL Surveillance MACE data in the #ACR21 plenary Discussions with pts needed, these data justify that need. @RheumNow

SELECT-AXIS 1: UPA 15 mg QD consistently efficacious over 2 years for ASAS40. Low radiographic progression rates in AS pts. No new safety findings were observed. Abs 0924 #ACR21 #RheumNow @RheumNow https://t.co/CWvH1OPGyR https://t.co/uC67fJZDCE

• Efficacy and Safety of Upadacitinib in Patients with Active Ankylosing Spondyli…

Abst0509 #ACR21 @RheumNow study of plasma concentrations of Deucravacitinib show high functional selectivity for TYK2 while Tofa, Upa & Bari inhibit JAK1/2/3 to varying degrees show no meaningful inhibition of TYK2. Distinct class of kinase inhibitor as compared to JAKs

SELECT-AXIS 1 Post Hoc Analysis results showed improvement in PROs & reduction in back pain score at 12 weeks predicted clinical outcomes at 1 year in AS pts. Abs 0926 #ACR21 #RheumNow @RheumNow https://t.co/vRVpv1O6YS https://t.co/wjafMf1UPY

• Predictors of 1-Year Treatment Response Among Upadacitinib-Treated Patients wit…