Abst0437 #ACR21 @RheumNow factors assoctd w/poor response to mRNA Covid-19 vaccine in rheum pts Rx w/Rituxan: ⬆️ exposure to RTX over time, ⬇️ IgG levels prior to RTX, short interval btw RTX course & BNT162b2 vacc. RA highest&ANCA-vasculitis lowest probability for a + response. https://t.co/DsrJBlNvr7

#ACR21 Abst#0457: #COVID19 Vaccine Responses In Patients w Autoimmune Diseas ⭐️Prosp observ: pre-vax▶️5 mo. ⭐️ 90% +Ab responses, but ⬇️ titer ⭐️MMF 21x⬇️ titer, MTX 4.4x⬇️, AZA 3.5⬇️ ⭐️BCDT: 58, JAK: 2.6, TNF 2.3 ⭐️GC ⬇️ even on <5mg! https://t.co/BGU4CP9M0s @Rheumnow #ACRbest https://t.co/7QhsTGTwnZ

• https://bit.ly/3BPavft

Sublingual Cyclobenzaprine for fibromyalgia. It seems to improve pain, and across the board on secondary endpoints. But all by a modest effect. Big placebo response also. Not time to get overly excited yet. Abstr#0477 #ACR21 @RheumNow https://t.co/aUtwaH5oEh

Wanted to highlight our work @HSpecialSurgery presented at #ACR21 using unsupervised clustering of multimodal data - histology and ultrasound to identify phenotypes such as moderately inflammatory subtype in #osteoarthritis @RheumNow #abst0212 some features highlighted in fig https://t.co/HRzhMXctB9

#ACR21 Abst#0284 My 56 yo ♀RA pt expressed concern for developing dementia last wk. This study helps recognize her RF beyond aging: ➡️ Large joint swelling (HR 2.2) ➡️ CVD (HR 2.4): stroke (HR 3.2) + chronic HF (HR 1.8) ➡️ DM (HR 1.6) #ACRBest @Rheumnow https://t.co/wsZnaLwSmD

• Risk Factors for Dementia in Patients with Incident Rheumatoid Arthritis: A Pop…

#ACR21 Plenary Abs#0457 @alhkim #COVaRiPAD study: 👉Patients with inflammatory diseases on #immunosuppression have impaired #SARSCoV2 immunity post-vaccine 👉#Steroids, MMF & B cell depletion therapy more severely affect responses 👉https://t.co/7qTABcpm0h @RheumNow #ACRBest https://t.co/EfuHjh3vw5

• Immunosuppression Attenuates Antibody and Neutralization Titers in Patients wit…

Abst0254 #ACR21 @RheumNow CARRA SJIA cohort defines factors associated with medication free remission for ≥6 month-period: younger age, normal CRP levels & shorter time btw diagnosis and start of Rx. none of pts who developed MAS (3.9%) able to d/c Rx for ≥6 months

COVID-19 mRNA vaccination immunogenicity (vs immunocompetent): TNFi: 2.3x reduction JAKi: 2.6x AZA: 3.5x MTX: 4.4x steroids: 9x (but confounded by other meds) MMF/MPA: 21x B cell depleting: 57.7x (but 6m gap probably helps) amazing work led by @alhkim #ACR21 ABST0457 @RheumNow https://t.co/cl5vBpNzvQ

Dr. @AlHKim on COVaRiPAD data: 274 pts chronic inflam dz (RA/SLE/IBD/SpA/MS/SS,/Vasculitis) vs 53 control 👉90% Ab+ response (⬇️3.4X titer) 👉MMF⬇️21X 👉MTX⬇️4.4X 👉AZA ⬇️3.5X 👉BCDT⬇️ 57.7X 👉JAKi ⬇️2.6 X 👉GCs⬇️9X 👉TNFi impaired neutralization delta #ACR21 #plenary @rheumnow https://t.co/b0DgLjDi6E

Provocative study in pre-RA. SC Abatacept in patients with pre-clinical RA can: -improvement MRI inflammation -⬇️evolution to clinical RA at 6 months -No new safety signal Yes, but we need longer term follow-up and an estimation of NNT. #OP0505 @Rheumnow #ACR2021 https://t.co/2P1Yk3IyeR

New treatments in #psoriaticarthritis Brepocitinib TYK 2/JAK 1 inhibitor had superior efficacy vs PBO in active PsA at Week 16, with improvements in more refractory domains over 52 weeks. Safety consistent with other JAKi @RheumNow #ACR21 Abstr#0488 https://t.co/ugsV7uRwro

• Efficacy and Safety of Brepocitinib (Tyrosine Kinase 2/Janus Kinase 1 Inhibitor…

#ACR21 #Abstr0456 How can we explain cognitive impairment in #lupus? Using f- and DCE-MRI, a study showed: 💠Abnormalities in brain functional connectivity 💠Extensive Blood-Brain Barrier leakage (BBB) BBB could be a future target @RheumNow https://t.co/KLeWfbQUQ0 https://t.co/ibNvBUWlMK

• Functional Connectivity, Enhanced Blood-Brain Barrier Leakage and Cognitive Imp…

Polyautoimmunity: axSpA and Familial Mediterranean Fever by Dr. Rachel Tate ( @uptoTate ) Mysteries behind polyautoimmunity have confounded rheumatologists for decades. One such association, the co-existence of FMF and axSpA, remains rare. https://t.co/GbU1ikeyQw #ACR21 https://t.co/dRd6yxjieS

• https://bit.ly/2Ym6Jwz

So what’s interesting is that type I IFNs actually tighten the BBB. Is this dysfunctional in SLE? Or does this argue that CI does not correlate with SLE disease activity perhaps? #ACR21 #ACRAmbassador https://t.co/y5x2k3NQFi

• Dr. John Cush on Twitter: &quot;Blood Brain Barrier leakage correlates w/ CNS d…

COVaRiPad study - Immunosuppression affects COVID-19 vax Ab levels. 247 pts, 90% seroconverted but @ reduced (3.4 fold) titers. Lowest w/ MMF (21x) and B cell Rx vs MTX/AZA (3-4x). Pts on B cell therapy should wait 6 mos to recv vax #ACR21 Abstr# 0457 https://t.co/1gkCsJSDBk