Don’t Hold the Benlysta, Take the Vaccine https://t.co/yBWj2U4ZnZ

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2 very large UK population studies (millions of pts) show there is no evidence that NSAID use yields harm in those infected with COVID related deaths. There is either no risk (HR 0.96; 0.80, 1.14) or a reduced risk (HR 0.78; 0.64, 0.94) in these studies. https://t.co/gazA83Ogis

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Osteitis in Systemic Sclerosis is UNCOMMON. French study of 48 pts shows 54% w/ osteitis beneath digital tip ulcers. Pain (75%), erythema (73%), warmth (73%) & 65% had high CRP. X‐ray, CT‐scans or MR. Antibiotics were 1st line therapy. https://t.co/o58gwq2SCC

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Low Risk of TB with Secukinumab https://t.co/ADdtMNxy2N https://t.co/YTY0eci5Y2

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Aurinia yesterday announced the FDA that the has approved voclosporin (Lupkynis) for Lupus Nephritis. Voclosporin is an oral calcineurin inhibitor to be used in combination with a background immunosuppressives to treat adultswith active lupus nephritis https://t.co/90ba2Iq0eU

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Today is the PDUFA date wherein the FDA decides the fate of Aurinias calcineurin inhibitor, Voclosporin, use in lupus nephritis. https://t.co/6du61xGrDq https://t.co/2knPWyNmu4

• https://www.nasdaq.com/articles/will-aurinia-pharmas-lupus-nephritis-drug-pass-…

COVID Vaccine Q & A - Dr Kevin Winthrop Dr. Cush interviews Dr. Kevin Winthrop (OHSU) on the use and caveats to COVID-19 vaccination in patients with rheumatic disease and taking biologic and DMARD therapies https://t.co/EJL6hVLnrp https://t.co/XOHk9T04rx

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MMWR reports 10 cases of anaphylaxis after 4 million doses of Moderna COVID-19 vaccine (2.5 cases per million doses administered). 9/10 occurred within 15 minutes of vaccination. No anaphylaxis-related deaths were reported. https://t.co/lyAVapQH6f

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Metanalysis of Rituximab use in EGPA (Churg-Strauss) found 19 cohort studies, 8 case series, 18 cases, for a total of 368 EGPA patients. RTX yielded 80% w/ complete or partial remission (w/ more complete responses in pANCA+ pts) https://t.co/PTVLSwCHPv https://t.co/PfjBOoi1S7

• https://academic.oup.com/rheumatology/advance-article-abstract/doi/10.1093/rheu…

Seronegativity in RA studied using sera and microarrays from 559 RA (283 ACPA-) found 9 autoAbs w/ >90% specificity for seroneg RA. anti-PTX3 & anti-DUSP11 had best performance w/ sensitivity 38% & specificity 88% https://t.co/HraZg7SQPZ https://t.co/6Z8ebvarVm

• https://ard.bmj.com/content/early/2021/01/14/annrheumdis-2020-218460?rss=1

Mortality Risk in Rheumatoid Lung Patients A Medicare claims analysis of rheumatoid arthritis (RA) patients showed that RA-associated interstitial lung disease (RA-ILD) was seen in nearly 5% of patients and was found to increase mortality risks. Read on: https://t.co/RJxDB8tiRu https://t.co/daZppFnteu

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Metanalysis RCTs of Antidepressants in painful conditions (LBP, sciatica, hip/knee OA) shows SNRIs (Cymbalta, Savella, Effexor etc) have a small & not clinically important for effect on back pain. A clinically important effect on OA cannot be excluded https://t.co/lGqeEHtbnK https://t.co/wcta0VVSqp

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QD Clinic - Smoking and RA: The dastardly, nastardly facts of smoking and RA https://t.co/H4jeFIXeGq https://t.co/xWxjzGZWQq

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