Dr. John Cush RheumNow
1 month 2 weeks ago
JAMA Patient Education Page on:
Therapeutic Use of Cannabis and Cannabinoids https://t.co/s6F7B9qLfr https://t.co/lpLGozJgvi
JAMA has published an overview of new considerations on Lyme disease, focusing on Diagnostics, Vaccines, and Prevention.
POETYK PsA-1 trial tested the disease modifying efficacy of deucravacitinib, a tyrosine kinase 2 (TYK2) inhibitor, in psoriatic arthritis (PsA) patients and was shown to be superior vs to placebo for clinical responses, patient-reported outcomes, and structural damage inhibition in PsA.
Dr. John Cush RheumNow
1 month 2 weeks ago
Study of 154 anti-Ku Ab+ pts (51 IMMM, 46 SLE, 30 Sjögrens, 27 Sc) = 60 (39%) had ILD - 75% progressed; more rapidly in males. BUT Ku+ is rare <4%, not specific, without clear clinical implications. Ku is a myositis-assoc Ab (like Ro52/Ro60, U1-RNP, PM/Scl) https://t.co/MHz8mdqDqi
Dr. John Cush RheumNow
1 month 2 weeks ago
UK Clinical Practice Research Database study RA pts 3134 on glucocorticoids (vs not 4142 matched controls). were identified. GC use assoc w/ signif risk of SSRI initiation risk - recent GC (adj OR 1.53) & past GC (aOR 1.40). GC effect or confounding dz activity? Think depression! https://t.co/WZLkQWlURC
Dr. John Cush RheumNow
1 month 2 weeks ago
NSAIDs reduces age-related macular degeneration. TriNetX study (2015-2024) looked at non-AMD pts & showed NSAID use (n 634794) had signif less AMD at 6 mos (HR 0.31), 1 yr (0.36), 3 yrs (0.42) & 5 yrs (0.48); w/ signif protective effect (HR 0.58), Same for ASA (0.72) & https://t.co/Cgxrz92Omt
Dr. John Cush RheumNow
1 month 2 weeks ago
Air Pollution Increases RA Activity and Flares
Koreans with rheumatoid arthritis (RA) showed increased disease activity and higher flare rates when exposed to relatively high levels of small atmospheric particulate matter, researchers reported.
https://t.co/9dZkTzivRz https://t.co/Reic3P5U6r
Dr. John Cush RheumNow
1 month 2 weeks ago
Rethinking Treatment of EGPA
Like MPA & GPA, the goals of EGPA are controlling initial organ damage and preventing relapse. But EGPA has the added challenge of chronic upper and lower respiratory tract involvement, allergic type 2 inflammations and risk of glucocorticoid https://t.co/KIVpyhsghg
Dr. John Cush RheumNow
1 month 2 weeks ago
Korean study of 1070 #RA pts. assessed for Dz activity & monthly pollution exposure (SO2, NO2, ozone, CO, PM10, PM2.5). Among 6 pollutants, PM2.5 signif incr risk of flare (adj OR 1.11) & DAS28-CRP, CDAI, TJC, SJC; more so w/ in women & nonsmokers & w/ prolonged PM2.5 exposure https://t.co/HgtWMz9LMs
Dr. John Cush RheumNow
1 month 2 weeks ago
“We may have all come on different ships; but we’re in the same boat now.”
-Martin Luther King, Jr.
Dr. John Cush RheumNow
1 month 2 weeks ago
Arrhythmias in Autoimmune Rheumatic Disease
A new review in the Journal of Cardiovascular Development and Disease (Tamirisa et al) synthesizes how SLE, RA, and SSc have an increased risk of arrhythmias and SCD attributable to shared immune pathways. These facts substantiate the https://t.co/j9AW26LE66
Dr. John Cush RheumNow
1 month 2 weeks ago
Best proof of difference betw Seropos vs seroneg RA from TREAT-EARLIER 12 mos study 236 clinically suspect arthralgia pts w/ subclinical Jt inflammation Rx w/ MTX vs PBO. MTX prevented RA only the seroneg RA (9 v 35%); But no protection in seropos RA (58 vs 65%) https://t.co/ufY9ZJmKgf
Dr. John Cush RheumNow
1 month 2 weeks ago
COLIPSO prospective study of psoriasis or psoriatic arthritis adults starting ts/bDMARDs; MRI done serially. 35 pts f/u for ~29 wks - MASLD. Only Rx w/ IL-17 inhibitors improved liver fat and inflammation in psoriatic disease as well as clinical outcomes. https://t.co/MFjvh5OJg2 https://t.co/k0C7RSvaaR
Dr. John Cush RheumNow
1 month 2 weeks ago
In a Cohort of 410 #SLE pts, there were 37 MALES who demonstrated a high prevalence of renal (IV/V lupus nephritis 49%) and a notable incidence of Plaquenil-related retinal toxicity. 62% on HCQ, but 22% D/C HCQ due to retinal toxicity or drug intolerance. https://t.co/VISwHO1wcK https://t.co/6SoD6mD5tf
Dr. John Cush RheumNow
1 month 2 weeks ago
True or False: Neuropsychiatric SLE (NPSLE) was associated with a higher odds ratio for cerebral atrophy compared to age.
See if you got it right in this week's RheumIQ quiz at https://t.co/yQn8cIT5Cw. https://t.co/YjHwLFclv4
