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J&J announced it has halted its combination biologic study in difficult to treat RA. Phase 2a DAISY proof-of-concept

Dr. John Cush RheumNow

1 year 1 month ago
J&J announced it has halted its combination biologic study in difficult to treat RA. Phase 2a DAISY proof-of-concept studied the combo of nipocalimab and TNFi in refractory RA, but 12 wk results failed to evidence of efficacy. https://t.co/T4n4GNqtVC v https://t.co/eSAwrEIYHc
GLP-1 receptor agonists use assoc w/ lower risk of uveitis compared vs controls. EHR study 258 026 ea on GLP-1RA or n

Dr. John Cush RheumNow

1 year 1 month ago
GLP-1 receptor agonists use assoc w/ lower risk of uveitis compared vs controls. EHR study 258 026 ea on GLP-1RA or not. GLP-1RAs exhibited roughly half the risk of developing uveitis. Protective effect greater than that of metformin & insulin but lower than SGLT2i https://t.co/w311b6swc3
Rheumatoid arthritis (RA) is a common autoimmune disease, and approximately 30%-40% of patients develop pulmonary complications such as idiopathic pulmonary fibrosis (IPF), but the causal relationship between the two has long been unclear. A team from Taizhou Hospital in Zhejiang Province conducted a study using multiple omics methods, including bidirectional Mendelian randomization, transcriptomics, and single-cell RNA sequencing.
On behalf of the American College of Rheumatology (ACR), we express deep concern over recent developments at the Centers for Disease Control and Prevention (CDC) that appear to undermine the agency’s longstanding commitment to science-based public health policy.
Crepitus Does Not Predict Earlier/Worse OA
  • EurekAlert!
Young adults who experience grinding or clicking sounds in their knees post-surgery may be alarmed, but new research from La Trobe University suggests these sounds may not signal early-onset osteoarthritis. Knee crepitus, the sound of cracking or grinding in the knee joint is very common across all age groups.  
ACR Urges Alaska and Montana to Strengthen Rheumatology Care

The American College of Rheumatology (ACR) is calling on

Dr. John Cush RheumNow

1 year 1 month ago
ACR Urges Alaska and Montana to Strengthen Rheumatology Care The American College of Rheumatology (ACR) is calling on Alaska and Montana to seize the opportunity to address critical gaps in rheumatology care by accessing funding from the Rural Health Transformation Program https://t.co/exHRCORcCG
Review of cancer-associated myositis (CAM) & assoc myositis-specific or myositis-associated autoantibodies. 2017 met

Dr. John Cush RheumNow

1 year 1 month ago
Review of cancer-associated myositis (CAM) & assoc myositis-specific or myositis-associated autoantibodies. 2017 meta-analysis 5 studies & 4538 pts w/ DM or PM, the cancer risk (SIR) for DM = 4.66, but PM = 1.75. Cancer risk ^^ w/ Low serum KL-6, TIF1γ, NXP2, HMGCR Abs https://t.co/xsOt4wPIXB
High cancer risk in myositis patients linked to autoantibodies- TIFF1g, NXP2, HMGCR. https://t.co/CECO78ESHi

Dr. John Cush RheumNow

1 year 1 month ago
High cancer risk in myositis patients linked to autoantibodies- TIFF1g, NXP2, HMGCR. https://t.co/CECO78ESHi
Interstitial lung disease is a group of conditions that cause inflammation and scarring in the lungs.

This JAMA Patien
1 year 1 month ago
Interstitial lung disease is a group of conditions that cause inflammation and scarring in the lungs. This JAMA Patient Page describes types and causes of interstitial lung disease as well as its diagnosis, treatment, and prognosis. https://t.co/WELKKR0SX7 https://t.co/ykzR16ja3L
Anti-MDA5 DM is assoc w/ rapidly progr ILD & mortality risk. 26 MD5+ DM pts (age 56.6 yrs; 7/26 male) Sxs: Gottrón?

Dr. John Cush RheumNow

1 year 1 month ago
Anti-MDA5 DM is assoc w/ rapidly progr ILD & mortality risk. 26 MD5+ DM pts (age 56.6 yrs; 7/26 male) Sxs: Gottrón’s (81%), ILD (73%), periungual erythema (69%), heliotrope (61%), V-sign (42%), arthritis (42%), weakness (38%), mechanic’s (35%), Raynaud’s (19%). 7/19 RP-ILD died https://t.co/ugbmKlXsBp
JAMA: Cognitive functional therapy (CFT) is effective in control of chronic low back pain. Study of 500 LBP pts Rx w/ us

Dr. John Cush RheumNow

1 year 1 month ago
JAMA: Cognitive functional therapy (CFT) is effective in control of chronic low back pain. Study of 500 LBP pts Rx w/ usual care, CFT, or CFT with biofeedback over 3 mos. F/U of ~ 300 pts found that the benefits extended up to 3 years after the intervention. https://t.co/dLv53M7Xkp
LIVE September 9th, 7PM EST
Join Drs. Sindhu Johnson, Anna-Maria Hoffmann-Vold, Scott Matson & Jack Cush, Moderator,

Dr. John Cush RheumNow

1 year 1 month ago
LIVE September 9th, 7PM EST Join Drs. Sindhu Johnson, Anna-Maria Hoffmann-Vold, Scott Matson & Jack Cush, Moderator, as they review ACR & EULAR #ILD guidelines. Where are we now? Where are we going? Don’t miss it! https://t.co/PVo0dbQLCn #Rheumatology #ILD https://t.co/gp1qfeEt3S
Long-term Lab Monitoring in RA is Inefficient

Annals of Internal Medicine has published a retrospective study of long-

Dr. John Cush RheumNow

1 year 1 month ago
Long-term Lab Monitoring in RA is Inefficient Annals of Internal Medicine has published a retrospective study of long-term routine laboratory toxicity monitoring (lt-RLTM) in patients receiving disease-modifying antirheumatic drug (DMARD) therapy showing that most very abnormal https://t.co/hytyH1qqED
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