Disseminated acanthamoeba : pt with modular painful skin lesions on his palms and scalp— initially dx’d with a cutaneous vasculitis- he got worse with immunosuppression. Imaging and histology shown #ThievesMarket #ACR24 @RheumNow https://t.co/FjJ0Sk0Kxt

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A#2583 Apremilast for axial inflamm in PsA, assess by CANDEN MRI scoring MOSAIC P4 open label trial Reduction in inflammation seen in vertebral bodies & posteriolateral, not in facet joints No changes in SPARCC SIJ, spine - though low baseline SIJ inflammation @RheumNow #ACR24 https://t.co/3GKEGJbtdc

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A#2584 Mease Zasocitinib TAK-279 - potent, selective TYK2i P2b, 12w PsA RCT 15/30 mg - similar response, better than PBO for ACR20/50/70, MDA, DAPSA, PASDAS 29% MDA v 13% PBO Safety no signal for MACE, cancer, serious ifn, death. Mild acne signal noted @RheumNow #ACR24 https://t.co/1eqD9R5fLe

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Selective TYK2i zasocitinib, results of Phase 2 DBRCT Dose dependent improvements in various PsA outcomes; NNT~5 for DAS28 remission, NNT~20 for PASDAS Hard to compare to current agents, somewhere between JAKs (woot!) & "apremlist zone" 🫣 #ACR24 @RheumNow Abstr#2584 #ACRbest https://t.co/t0y6C618ll

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A#2585 PsABIOnd observ cohort study of IL23 (GUS) or IL17i 6 mo interim results of 686 pts PROs: PsAID-12 High Rx persistence at 6mo -94% on both Rx Comparable improvement in PsAID-12 - best results skin, discomfort 1/2 with clinically meaningful improvement #ACR24 @RheumNow https://t.co/TM1jwTRR7C

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Dr. CStone et al. assessed nailfold dermoscopy in distinguishing DM from SLE Almost all DM pts had nailfold changes in at least 1 digit vs. SLE & majority of DM pts had nailfold changes in all 10 digits Dermoscopy is a simple alternative to capillaroscopy @rheumNow #ACR24 ab2404 https://t.co/6tEXAlX7lt

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A systematic review & meta-analysis by Dr. JBCorrea et al show that the ff immune-mediated dses are assocd w/⬆️ ocurrence risk after covid19 infection 👇 Behcets SpA SS SLE PMR Pso RA Sjogrens T1DM Vasculitis IBD Ask prior covid infexn in pts history @RheumNow #ACR24 abs2614 https://t.co/TIEglPrmvL

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Neuropsychiatric manifestations in SLE. Susanne Benseler MD @RheumNow #ACR24 https://t.co/subiykC5Q4

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A#2586 EBIO study - secukinumab on entheseal bx in PsA. Compare b/l to 3+ mo on SEC Biopsy: change of entheseal cell composition on IL-17A Rx - decr Il-17A producing cells in responding pts Spatial transcriptomics - colocalizarjon of ILC2, CD200+ fibroblasts @RheumNow #ACR24 https://t.co/kMiqpBRxuE

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Neuroimaging is done to support the diagnosis of CNS #lupus but only 75% reveal abnormal brain MRI. 📌 It is more useful in pts with local deficits than diffuse. 📌 poorly correlated with cognitive dysfunction & psych phenotypes. @Rheumnow #ACR24 @rheumarhyme @theactiverheum https://t.co/HjNbVBaOHv

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The different NPSLE syndromes 👇 Highlighted in yellow are the most common manifestations. 🧠 - Cognitive dysfunction - Mood disorder - Anxiety disorder @RheumNow #ACR24 https://t.co/1I7OVPT6DK

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A higher number of axSpA pts enrolled in BE MOBILE 1&2 who were treated with BKZ achieved remission accdg to the OSI vs. ASDAS ID (40.5% vs 15.2%) at wk 16 until wk 52. OSI a better measure of remission? @RheumNow #ACR24 abs2362 https://t.co/GCHjXQi9S9

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Diagnostic work up for neuropsychiatric SLE. Zahi Touma MD @RheumNow #ACR24 https://t.co/zLX1QHCaSu

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Dr @ZahiTouma discusses the attribution rules for the NPSLE syndromes Attribute to #SLE if - onset of NP is near the SLE dx - absence of concurrent nonSLE factors - ⬇️ frequency of NP events in the gen pop'n - diagnostic tools favor NPSLE @RheumNow #ACR24 https://t.co/e1xBK4Xzsw

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Very informative slide describing the 2 NPSLE pathogenetic pathways & their differences in mediators, mechanisms and NP events. @RheumNow #ACR24 @rheumarhyme @theactiverheum https://t.co/D3XFDqxMBq

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