JAMA Dermatology has published a review of dermatomyositis (DM), focusing on similar and different manifestations of DM.
DM affects all races, but it has been suggested that racial and ethnic minority patients may have more severe disease and a different autoantibody profile. This analysis characterizes the clinical features and outcomes of DM in Hispanic and non-Hispanic patients.
Dr. John Cush RheumNow
2 years ago
The Burden of Rheumatoid Arthritis (2018–2020)
A recent study that quantified the economic and humanistic burden of RA in the US showed significantly higher health care expenditures, particularly medication costs, and suboptimal quality of life in RA.
https://t.co/1v3CDtZC0l https://t.co/WPWuOvpkfa
A recent article in PLOS ONE has shown that treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists (GLP-1-RAs) was associated with a significant lowering of risk of all-cause mortality and major adverse cardiovascular events in patients with immune-mediated inflammatory diseases and type 2 diabetes.
Dr. John Cush RheumNow
2 years ago
Depends on Where You’re Looking (8.9.2024)
https://t.co/GDAN37DJSx https://t.co/jVoumC00r5
Sjögren's disease is a chronic autoimmune condition without a clear effective therapy - DMARD or biologic. The TWINSS study has demonstrated the safety and efficacy of iscalimab, a monoclonal antibody against CD40, in a phase 2 randomized clinical trial of active Sjögren's disease (SD).
Dr. John Cush RheumNow
2 years ago
Mass General Brigham Study 172 RA-ILD pts w/ 6.5 yrs F/U (age 62 yrs): noted (4%) lung transplants & 44 (26%) ILD-related deaths. FVC rapidly declining pts (14%) had aOR 19x lung transplant & aOR 2.8 ILD-related death. Slow decline in 54%, no decline 32% https://t.co/fKDnJIu9a7 https://t.co/ondzN4WZ1F
Dr. John Cush RheumNow
2 years ago
Favorable results from Vasculitis Pregnancy Registry; enrolled 147 women, 149 pregnancies; data on 78 pregs. 36% had active vasculitis during Preg, 14 hospitalized (4 w/ vasculitis. 74% Rx vasculitis meds during preg & 97% live births, 21% preterm https://t.co/rq2Y4ij0OW https://t.co/wmmFPvlOGY
A Canadian cohort of difficult-to-treat rheumatoid arthritis (D2T RA) patients shows significantly more non-inflammatory pain in D2T RA compared to patients responding to b/tsDMARDs.
Dr. John Cush RheumNow
2 years ago
EMR study looked at NIDDM & 4 indicators of #Obesity (waist circumference, waist/hip ratio, BMI, & visceral fat area -- 600 gout pts vs 9,935 controls shows all obesity measures signif incr odds of #Gout (OR 1.775, 1.691, 1.858, & 1.578, respectively) https://t.co/JJn5txgxiN https://t.co/tgnWWl9COe
A recent study that quantified the economic and humanistic burden of rheumatoid arthritis (RA) in the USA showed significantly higher health care expenditures, particularly medication costs, and suboptimal quality of life in RA.
A matched cohort study from the Veterans Health Administration shows that rheumatoid arthritis patients have a >50% increased risk of lung cancer, and a 3-fold higher risk of lung cancer in RA-interstitial lung disease (ILD).
Dr. John Cush RheumNow
2 years ago
Breast CA (BC) & TNFi - study of 2 cohorts (Optum commercial * SEER/Medicare) found that 17% & 16% of BC pts received TNFi. 1 yr overall survival was no different +/- TNFi (HR= 0.77 & 0.84); but BC survival better on TNFi (HR 0.28; 0.08–0.98) vs csDMARDs. https://t.co/cGqT80rGTR https://t.co/n7i5VNFkVT
Dr. John Cush RheumNow
2 years ago
Oral microbiota study (w/ 16S rRNA sequencing) of 72 severe psoriasis vs 16 controls. PsA pts had incr in Aggregatibacter & decr Prevotella. PsO pts had incr in Capnocytandophaga, Campylobacter & Acetobacter, but decr Bacteroides & Muribaculaceae https://t.co/ol947Afupt https://t.co/OknMRtJ4oT
Dr. John Cush RheumNow
2 years ago
Prescription Painkiller Misuse in Chronic Pain Patients
A new scientific review has found that nearly 1 in 10 patients experiences opioid dependence or opioid use disorder and nearly 1 in 3 shows symptoms of dependence and opioid use disorder.
https://t.co/DnUe1l51bS https://t.co/G4RPg8eqqe
Dr. John Cush RheumNow
2 years ago
Review of Inflammatory vs non-inflammatory pain in RA
- Pain may be more than inflammation
- Residual plain is a problem
- Consider damage vs FM
- Central vs. Neuogenic pain https://t.co/JUgc5IsgMq https://t.co/CRekJsAP04

