Dr. John Cush RheumNow
2 years 1 month ago
Novel: 2 case reports of refractory macrophage activation syndrome successfully treated w/ an investigational monoclonal Ab (MAS825 ) to IL-1β, and IL-18 https://t.co/ZqC77njbjk https://t.co/13W8RZIiRZ
Dr. John Cush RheumNow
2 years 1 month ago
Study of 425 RA pts & 36 mo. bDMARD retention rates w/ TNFi, IL-6i & ABA based on renal funct (eGFR: ≥60, 30–60, <30 mL/min) showing little effect of CKD w/ TNFi (45%, 28%, 34%), IL-6i (47%, 67%, 71%) & CTLA-4Ig (50%, 31%, 33%), maybe lower w/ TNFi & higher w/ IL6i… https://t.co/FhXoSnEfG1 https://t.co/N29nLBOoUj
Sjögren disease (SjD) is highly prevalent, but diagnosis may be challenged if anti-SSA antibodies or a labial salivary gland biopsy are negative. A recent cohort analysis suggests a novel autoantibody profile has predictive value SSA negative SjD and also in those with a positive labial biopsy.
A retrospective study in giant cell arteritis (GCA) patients suggests there is no added value using higher dose, intravenous methylprednisolone (IVMP) in early GCA.
Dr. John Cush RheumNow
2 years 1 month ago
New CDC guidance on Influenza vaccination!! All should recv, ideally in September or October. Immunocompromised (by meds or Dx) should recv Trivalent inactivated (IIV3s) & trivalent recombinant vaccine (RIV3), but not the live virus vaccine (LAIV3) https://t.co/r7euIb3BV9 https://t.co/Tx2pU2Onng
A Danish registry study has shown that amongst those patients who develop inflammatory arthritis (IA), antibiotics use was more frequent when compared to the background population (BP).
Dr. John Cush RheumNow
2 years 1 month ago
All in the Family (8.23.2024)
Dr. Jack Cush picks highlight reports from the past week on RheumNow, with reports on the challenge of lupus nephritis, perplexing skin issues, you don't know JAK (about Tyk) and the value of a good family history.
https://t.co/gwM77mJCnr https://t.co/HOGnymjhSZ
Dr. John Cush RheumNow
2 years 1 month ago
ANCA-associated vasculitis analysis of 6 European registries, 3868 pts (2434 GPA, 1434 MPA), age ~57 yrs. Identified 5 clusters: 3 w/ renal dz a) variable ANCA, Hi CRP & Cr; b) MPO+; c) PR3+ & 2 extrarenal 1) PR3+ multisystem; 2) ENT w/ low CRP. Clusters better predicted outcomes… https://t.co/20O58AAYAa https://t.co/KF6PTVfcRw
Dr. John Cush RheumNow
2 years 1 month ago
Global Rheumatoid Arthritis Market estimated to be worth USD 22.77 billion in 2021 and is predicted to expand to USD 33.30 billion by 2030, with annual growth of 4.5% during the forecast period 2022-2030. https://t.co/J64mVxY4Ia https://t.co/6zg5g6KRdJ
Dr. John Cush RheumNow
2 years 1 month ago
Cohort study shows GERD in 1539/1632 (94%) #SSc patients & 450/469 (96%) of SSc-ILD pts. GERD didnt influence ILD Dx or severity. But GERD Rx (PPI, H2RA) assoc w/ improved survival in those Scleroderma pts with ILD (p = 0.002) https://t.co/stQkpbmBCP https://t.co/e4BBz5c0av
Dr. John Cush RheumNow
2 years 1 month ago
MDs: How long must you be on Pred 40 mg/d before you must slowly wean pred (vs stopping abruptly)?
Dr. John Cush RheumNow
2 years 1 month ago
New $$$ drugs are NOT usually steroid sparing, but a single center 716 RA pt study compared JAKi (n 156) vs bDMARDs (560) starts; JAKi assoc w/ more rapid GC reduction in1st 6 mos & 60% higher odds of GC D/C (adj OR 1.63) (>50% vs 40% @12 mos) https://t.co/shiDytQeBU https://t.co/dCjyw21uLd
Published guidelines on lupus management urge that female patients plan and prepare carefully for pregnancy, and use contraceptives when it's not intended -- but these recommendations are only rarely followed, a registry study suggested.
The American College of Rheumatology submitted comments to the U.S. Food & Drug Administration supporting their recent proposal to update the approval process for biosimilars’ interchangeability status by repealing the requirement for switching studies while also encouraging the FDA to continue monitoring the downstream effects of this policy to ensure transparency for patients and prescribing providers.
ACR_Journals ACR_Journals
2 years 1 month ago
Among spondyloarthritis patients with clinical enthesitis, 68% had no ‘active enthesitis’ on ultrasound. Conversely, of those without signs of clinical enthesitis, 15% showed subclinical enthesitis on ultrasound
↓ https://t.co/aVEvOmcEHK

