Dr. John Cush RheumNow
2 years 2 months ago
Pain Reduction with Methotrexate in Knee Osteoarthritis
The Annals of Internal Medicine reports that oral, low dose, weekly methotrexate significantly reduced knee osteoarthritis (KOA) pain, stiffness, and function in a randomized controlled trial.
https://t.co/ayMD1V67fH https://t.co/Es3oPYM8Y3
Dr. John Cush RheumNow
2 years 2 months ago
Medical literature review of suggests low vitamin D status is common in Rheumatic pts. & low vit D levels linked to loss of muscle strength, MSK pain, sarcopenia & falls (esp in IIM, PMR, SLE, RA, SSc) (BUT DOES REPLACING VITAMIN D FIX THESE PROBLEMS???) https://t.co/30IiKj7l4d https://t.co/ydU6FQMTi5
Dr. John Cush RheumNow
2 years 2 months ago
PEXIVAS: Diffuse Alveolar Hemorrhage in ANCA-Associated Vasculitis Patients
The PEXIVAS study found potential benefits of plasma exchange and glucocorticoids for AAV patients with DAH, but the results did not reach statistical significance.
https://t.co/m7BxMfj04W https://t.co/A9SKAWd1s5
Dr. John Cush RheumNow
2 years 2 months ago
Calcinosis cutis affects 40% of SSc pts w/ significant morbidity. Assoc w/ Long Dz duration, vascular dysfunction, & osteoporosis. Dx by radiography. Surgical treatment is most effective therapy, but no medical therapies have proven efficacy in RCTs https://t.co/ocQ5okBauq https://t.co/1DUm6FKfm8
Dr. John Cush RheumNow
2 years 2 months ago
Melatonin doesnt work! 172 pts w/ unilateral TKA for Rx in DBRPCT trial of qhs 5 mg melatonin vs. 125 mg vit C placebo for 6 weeks. No differences in PSQI or other sleep measures @6wks. Poor sleep assoc w/ worse pt function and pain. https://t.co/b1gfnyB7Qw https://t.co/nT589CItIF
Dr. John Cush RheumNow
2 years 2 months ago
Guselkumab maintenance dose is 100 mg sc q8wks. GUIDE ph 3b trial treated 297 PSO super responders (PASI <3) w/ q8wk or extended q16wk GUS & demonstrated noninferiority of q16 wk dosing w/ disease control (91.9 vs 92.6%) https://t.co/31DPTmcVD2 https://t.co/qHMsyYCH4J
Dr. John Cush RheumNow
2 years 2 months ago
Review of Calcium Pyrophosphate Deposition Disease
Lancet Rheumatology has published a review of Calcium pyrophosphate deposition (CPPD) disease - a chronic inflammatory and degenerative crystal arthropathy that increases with aging.
https://t.co/svIGF3hM0Y https://t.co/17CNkOiGPB
Dr. John Cush RheumNow
2 years 2 months ago
NSAIDs Used Despite Contraindications
https://t.co/elhnmB3N52 https://t.co/VgIqKvkfVJ
Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com - leading with lupus because everyone wants to know about lupus!
Dr. John Cush RheumNow
2 years 2 months ago
Arthritis drugs may relieve long COVID lung symptoms
University of Virginia SOM researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs.
https://t.co/4gqVhzOEMg https://t.co/NEysSjRE8c
An international cohort study of patients with calcium pyrophosphate deposition (CPPD) disease, i.e., recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS) identifies both acute and chronic inflammatory phenotypes, each with distinctive clinical and imaging diagnostic features.
Dr. John Cush RheumNow
2 years 2 months ago
US Childrens Hosp Admission database finds 8588 kids w/ SLE & ≥ 1 hospitalization; 13% for infections, w/ Bacterial pneumonia most common. cSLE In-hospital mortality in 0.4%, but 2% for infection. Highest mortality w/ PJP (21%), fungal infx (21%) https://t.co/fmyRXagCcD https://t.co/yXDMFYhhdP
JAMA reports that following the COVID-19 pandemic US adults trust in physicians and hospitals decreased, and was associated with lower odds of COVID vaccination.
Dr. John Cush RheumNow
2 years 2 months ago
Full read review of tendinopathies - triggers (mechanical, intrinsic, extrinsic), biology, biomechanics & repair. Despite multivariable biologic disruptions, tendinopathies is mostly restricted to symptomatic therapy. https://t.co/h2D3fbUNVO https://t.co/2rmw6E0F6Z
