Izokibep Ph2b/3 RCT PsA 340+ Primary endpoint ACR50 wk 16 IZO 160 mg Q2W 43% IZO 160 mg QW 40% PBO 15% Effect early as wk 4 PASI100 IZO Q2W 47% IZO QW 51% PBO 12% Safety profile similar to IL-17i @RheumNow #EULAR2024 LBA0005 https://t.co/vWRQ1ECrAX

• https://twitter.com/AurelieRheumo/status/1801901877417636106/photo/1

ReMonit RCT 240+ axSPA pts Remote Monitoring & Patient-initiated Care NON INFERIOR Usual care for ASDAS <2.1 over 18mo No diff between Patient-initiated Care & Remote Monitoring No diff in disease activity & function >90% satisfaction in all arms #EULAR2024 @RheumNow LB0004 https://t.co/mLTS5fLXFN

• https://twitter.com/AurelieRheumo/status/1801898253610365272/photo/1

This is critical. If we're going to try and treat pre-RA, it's all about picking the right patient: - avoid exposing future non-responders to harm - modify the course of disease in those who will benefit Fantastic that @eular_org are addressing this need. #EULAR2024 @RheumNow https://t.co/9pF33eLbuZ

• https://twitter.com/Stiddyo/status/1801892223312617572

Scleroderma: the present, and the future. #EULAR2024 @RheumNow https://t.co/v5vxfmM4i3

• https://twitter.com/drdavidliew/status/1801896558184845375/photo/1

Open-label extension of BE MOBILE 2 Ph3 Bimekizumab in r-axSpA 200 pts w/ 2yr radiographic outcome 85.3% non progressors (mSASSS CfB ≤0.5) 92.1% (mSASSS CfB <2) 83.1% had existing structural damage (mSASSS ≥2) at BL #EULAR2024 @RheumNow Abst LBA0003 https://t.co/DQeiXHDnSF

• https://twitter.com/AurelieRheumo/status/1801896517608878481/photo/1

PRO-SPIRIT 1100+ PsA Observational study IXE i= TNFi and JAKi for improving joint dis activity in IXE higher previous b/tsDMARD & less concomitant csDMARDs IXE & IL-17Ai = faster improvement cDAPSA than IL-12/23i or IL-23i Abst LBA0002 #EULAR2024 @RheumNow https://t.co/8DbtCQECNN

• https://twitter.com/AurelieRheumo/status/1801895455757852889/photo/1

IL-6 Immunotherapy for knee OA PPV-06 FTIH Phase 1 Is it safe? looks it, no serious AES, 6mo follow up Is it immunogenic? apparently so, IL-6 Ab & neutralizing Ab Does it work? will have to wait for Phase 2 Somehow bold knowing TCZ did not work in hand OA AbstLBA0011 #EULAR2024… https://t.co/pO0Dx3jl8E https://t.co/p1zYUtgFoM

• https://twitter.com/i/web/status/1801894324684157080
• https://twitter.com/AurelieRheumo/status/1801894324684157080/photo/1
• https://twitter.com/AurelieRheumo/status/1801894324684157080/photo/1

#Scleroderma updated #EULAR2024 #recommendations @eular_org SKIN Are they good enough? Great work by task force @EUSTAR_org Do we alter initial Rx if v high mRSS? Ex #MMF not much improvement on skin vs #RTX #Cyclo Or combo Rx? We need to improve #SoC ?CAR-T ? RCT @RheumNow https://t.co/WhEzDdjVeu

• https://twitter.com/Janetbirdope/status/1801893420929040497/photo/1

#Scleroderma updated #EULAR2024 #recommendations @eular_org Are they good enough? Great work by task force @EUSTAR_org #PAH my thoughts Where does #sotaracept in #PAH fit in Not mentioned ?#selexipag before #epoprostenol For sure there is country variant @RheumNow https://t.co/3dJ6eusSkU

• https://twitter.com/Janetbirdope/status/1801891493726106028/photo/1
• https://twitter.com/Janetbirdope/status/1801891493726106028/photo/1

#EULAR2024 LBA0001 New Steroid-sparring therapy for #GCA. Phase 3 RCT showed Upadacitinib 15mg met primary endpoint (sustained clin remission frm Wks 12-52 & adherence to 26Wk GC taper) vs PBO [46% vs 29%] & multiple secondary endpoints. No new safety signals @RheumNow https://t.co/edfSZkMuy2

• https://twitter.com/Yuz6Yusof/status/1801890562221466088/photo/1

LBA0001 UPA in GCA- Phase 2 RCT 15mg UPA with 26w steroid taper showed ⬆️ efficacy ⬇️ steroid use vs placebo with 52w steroid taper Potential new target on the horizon for #GCA?? @RheumNow #EULAR2024

#EULAR2024 POS0417 Using EXPLORE Inflammation I & II proteomics, marked immune dysregulation was seen in new ANA+ referral vs HC. 34% progressed to #lupus & #Sjogren. Six potential baseline biomarkers identified & closely resembled established SLE. Validation is ongoing @RheumNow https://t.co/I6HygqNwf7

• https://twitter.com/Yuz6Yusof/status/1801887094282789134/photo/1

Nipocalimab (anti-FcRn - i.e. PLEX-in-a-bottle) with a positive phase 2 in Sjogren’s. This study is in high systemic dx pts (with nice response matching biological plausibility) - but salivary flow improved too ESSPRI didn’t quite make it, but close #EULAR2024 LBA0010 @RheumNow https://t.co/PslFKJBOOr

• https://twitter.com/drdavidliew/status/1801886350591099208/photo/1
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EFFICACY & SAFETY OF IZOKIBEP, A NOVEL IL-17A INHIBITOR, IN PATIENTS WITH ACTIVE PSA: WEEK 16 RESULTS FROM A RANDOMIZED, DB,PBO CONTROLLED, MULTICENTER 2b/3 STUDY ACR responses 60:40:20 42% MDA PASI 100 47% ho hum same as others-how many IL17s do we need ? @RheumNow #EULAR2024

Points to consider in pregnancy &lactation in Pts w #rheumatic #diseases #biologics don’t increase rate of serious infections in Mom Baby Compared to other matched pregnant and post partum women reassuring! #EULAR2024 @RheumNow @eular_org