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John H Stone’s #IgG4RD lessons:
1-It is a variable-vessel vasculitis
2-more common/severe in males (2:1)
3-Has no diag

Vasco C Romao romaovc

2 years 2 months ago
John H Stone’s #IgG4RD lessons: 1-It is a variable-vessel vasculitis 2-more common/severe in males (2:1) 3-Has no diagnostic histopathology 4-IgG4 does not cause IgG4RD 5-Serum igg4 is a good biomarker 6-Rising IgG4 shouldn’t be ignored #EULAR2024 https://t.co/7p6pBqI4ue
RA specific bone signatures (markers) detected by machine learning. Abst#0125
Dkk1 increased in erosive RA #EULAR2024 @

Bella Mehta bella_mehta

2 years 2 months ago
RA specific bone signatures (markers) detected by machine learning. Abst#0125 Dkk1 increased in erosive RA #EULAR2024 @RheumNow https://t.co/0A5C9LCzle
Fibroblasts activated -> secrete chemokines which lead to granzyme K production inturn leading to damage to mitochon

Bella Mehta bella_mehta

2 years 2 months ago
Fibroblasts activated -> secrete chemokines which lead to granzyme K production inturn leading to damage to mitochondria - release of mitochondrial DNA and production of interferon type 1 which ultimately lead to infiltrates (which contribute to the worsening saliva production) https://t.co/jZkU3SBhwc
Single cell analysis with 12 groups
Those patient without lymphocytic infiltrates were different!
Mitochondria were the

Bella Mehta bella_mehta

2 years 2 months ago
Single cell analysis with 12 groups Those patient without lymphocytic infiltrates were different! Mitochondria were the differentiator in these patients. Fibroblasts and CD8+ T cells are the most actively communicating cells. - Chemokines and ECM https://t.co/Pe0WSoYdXT
🗣️Lowering glucocorticoids dose remains a key goal in #lupus management

Prof @EricFMorand at #EULAR2024

#letpush

Matteo Piga RMD_clinic

2 years 2 months ago
🗣️Lowering glucocorticoids dose remains a key goal in #lupus management Prof @EricFMorand at #EULAR2024 #letpushbelow5 mg of prednisone in #SLE https://t.co/IeiLh2zVrT
#EULAR2024

Reminder …
🔺Anti-drug antibodies cause significant variability in Therapeutic drug levels

🔺10% ha

Dr Gurdeep S Dulay gurdeep_dulay

2 years 2 months ago
#EULAR2024 Reminder … 🔺Anti-drug antibodies cause significant variability in Therapeutic drug levels 🔺10% have undetectable drug level after 3 months of Rx 🔺is therapeutic drug monitoring is beneficial? 🤔 https://t.co/ChgMnKPyFb
RISK OF NON-MELANOMA SKIN CANCER WITH TNFi AND OTHER bDMARDs IN PATIENTS WITH PSORIATIC ARTHRITIS: A SWEDISH AND DANISH

Peter Nash drpnash

2 years 2 months ago
RISK OF NON-MELANOMA SKIN CANCER WITH TNFi AND OTHER bDMARDs IN PATIENTS WITH PSORIATIC ARTHRITIS: A SWEDISH AND DANISH COHORT STUDY- despite having minimal sun 25% increase NMSC TNFis vs other bDMARDs - skin checks !@rheumnow #EULAR2024
steroid dose 120 mg , repeated if not in remission 12 wks on background MTX - no difference between groups @rheumnow #EU

Peter Nash drpnash

2 years 2 months ago
steroid dose 120 mg , repeated if not in remission 12 wks on background MTX - no difference between groups @rheumnow #EULAR2024 https://t.co/gkqmElfOCp
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