Aurelie Najm AurelieRheumo
2 years 4 months ago
Cohort from Netherlands 400+ PsA pts IR first bioDMARD
300+ switched TNFi->IL-17i, 99 cycled TNFi->TNFi
3year retention rates
12 mo 75% cyclers 80% swappers
24mo 60% cyclers 56% swappers
No difference in treatment failure or DAS28 CRP
#EULAR2024 @RheumNow POS0278 https://t.co/J8ONjVAFqG
Aurelie Najm AurelieRheumo
2 years 4 months ago
What is the meaning of mechanical stress-induced sacroiliac BMO MRI after childbirth in healthy women?
5yrs follow up MRI study shows:
-decrease in BMO
-1/3 BMO @ 5-year follow-up
-15% ASAS definition of sacroiliitis
-No correlation w/ symptoms
@RheumNow #EULAR24 OP0222
Aurelie Najm AurelieRheumo
2 years 4 months ago
Understudied neurological involvement 🧠in RA
in pts > 65 vs. matched HC
-larger lateral cerebral ventricles
-brain atrophy
-shrinkage of thalamus + frontal cortical regions
-association w/ clinical depression
@RheumNow POS0148 #EULAR2024 https://t.co/2mV4qGyBtW
Aurelie Najm AurelieRheumo
2 years 4 months ago
BARI reduces nociplastic pain, small cohort RA n=13
-wk 12 ACR FM score 14 vs 10.5 p=0.03
-fMRI data: reduction connectivity between DMN and posterior insula & between IPL & anterior/middle insular regions
Directs mechanims yet to be investigated
@RheumNow POS0310 #EULAR2024 https://t.co/jGgvS5qqV6
Aurelie Najm AurelieRheumo
2 years 4 months ago
Is RA always preceded by clinically suspect arthralgia? Cohort 650+ pts CSA = 83 pts no CSA = 616 pts
Pts w/ no CSA: -older -more frequent acute onset of symptoms -higher SJC -increased CRP -less ACPA+ No sure how accounted for memory bias
#EULAR2024 @RheumNow POS1030 https://t.co/dJeN41ax5P
Peter Nash drpnash
2 years 4 months ago
9 new MOAs in SLE to review - anti-cd38, cd40, ubiquitin ligase, tyk2, toll 7/8, baff-r, blyss/april, CAR-T, glycosylated cd20 @rheumnow #EULAR2024
Peter Nash drpnash
2 years 4 months ago
EFFICACY AND SAFETY OUTCOMES OF TAK-279, A SELECTIVE ORAL TYROSINE KINASE 2 (TYK2) INHIBITOR, FROM A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 2B TRIAL IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS - smells tastes & looks like a Tyk2 - acne signal? @rheumnow #EULAR2024
Peter Nash drpnash
2 years 4 months ago
EFFECTIVENESS & COST-EFFECTIVENESS OF PATIENT-INITIATED FOLLOW-UP SUPPORTED BY ASYNCHRONOUS TELEMONITORING IN SPA (TeleSpA-STUDY): PRAGMATIC MULTICENTRE RVT cost effective but no one will ever be examined again especially for pathology outside joints! @rheumnow #EULAR2024
Peter Nash drpnash
2 years 4 months ago
FAPI PET/CT entheseal & synovial fibroblast activation predicts PsA in high risk PsO better than MUS @RheumNow #EULAR2024 https://t.co/uqmEvMg9WN
Peter Nash drpnash
2 years 4 months ago
more evidence in PsA - switch MOA rather than cycle within class failed first TNF @RheumNow #EULAR2024 https://t.co/hf2UB5MXEy
Peter Nash drpnash
2 years 4 months ago
opposing point of view especially in males at 3 years !@RheumNow #EULAR2024 https://t.co/CXxIScQbFD
The development of JAK inhibitors represents an advance for the treatment of inflammatory rheumatic diseases. However, the enthusiasm in using this target has waned since the publication of the ORAL surveillance clinical trial in 2022. Subsequently, both the FDA and EMA issued a warning on using JAKi in patients with certain risk factors, e.g., ≥65 years, at increased risk of MACE, current smoker or past smoker and at increased risk of cancer,
Janet Pope Janetbirdope
2 years 4 months ago
#wasup in #GCA?
#upadacitinib +RCT in #temporal #arteritis LBA0001
Residual #inflammation in 1/3 of pts at 6 mo #Rx w #TCZ on repeat TA Bx
OP0621
#PMR cases
#Leflunomide beats #MTX for
#pred sparing
⬇️relapses
But MTX dose was low
POS0280
#EULAR2024 @RheumNow @eular_org
Janet Pope Janetbirdope
2 years 4 months ago
New #JAKi #disease #results
#Baricitinib in #alopecia #areata esp 4mg/d
#Upadacitinib in Crohn’s
#Upa in #polyarticular #JIA & kid #PsA
+RCT of UPA in #GCA
Awaiting results of #SLE
With #deucravicitinib & UPA #RCTs
#EULAR2024 @eular_org @RheumNow
Janet Pope Janetbirdope
2 years 4 months ago
#Behcet’s #syndrome is increasing in the UK
? ⬆️ Detection
? Changing population demographics
? Other reasons
Poster discussion POS0258
#EULAR2024 @RheumNow @eular_org
@Pr1yankaC https://t.co/SEzmJnFMhM
